Award Data

TANOX BIOSYSTEMS, INC., HAS GENERATED AN ANTI-IDIOTYPE (ID) MONOCLONAL ANTIBODY (MAB), AB19-4, TO THE HIV-1-NEUTRALIZING MAB, BAT123, WHICH RECOGNIZES AN IMMUNODOMINANT REGION OF GP120. RESEARCH HAS CHARACTERIZED AB19-4 TO BE A PARATOPE-SPECIFIC ANTI-ID MAB THAT MIMICS THE THREE-DIMENSIONAL STRUCTURE OF NEUTRALIZING EPITOPES OF THE VIRUS. FURTHERMORE, POLYCLONAL RESPONSES OBTAINED FROM RABBITS IMM ...

IT IS PLANNED TO DEVELOP A LASER PLUME ANALYSIS INSTRUMENTATION SYSTEM THAT IS SUITABLE FOR QUANTITATIVE MEASUREMENTS ON POTENTIALLY HARMFUL TISSUE ABLATION BY-PRODUCTS SUCH AS TOXIC VAPOR SPECIES IN LASER PLUMES GENERATED BY LASER SURGERY PROCEDURES. IN PHASE I, CANDIDATE LASER PLUME ANALYSIS INSTRUMENTS WILL BE EVALUATEDFOR THEIR UTILITY IN MEASURING TISSUE ABLATION BY-PRODUCTS PRODUCED BY ARGON ...

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THE OBJECTIVE OF THIS EFFORT IS TO DEVELOP A MECHANICAL SURGICAL DEVICE THAT WILL BE CAPABLE OF EFFICIENTLY AND EFFECTIVELY REMOVING THE GRANULATION TISSUE ENCOUNTERED IN PERIODONTAL SURGERY. METHODS CURRENTLY UTILIZED IN THE SURGICAL REMOVAL OF GRANULATION TISSUE ARE EXTREMELY TIME CONSUMING AND LABORIOUS. FURTHER, THE INCREASED EMPHASIS ONREGENERATIVE SURGERY HAS STRAINED THE ABILITY OF THE CURR ...

THIS PROJECT WILL DEVELOP A THERMAL PROBE TO NONINVASIVELY MEASURE LOCAL BLOOD PERFUSION IN TISSUE. THE DEVICE WILL CONSIST OF A SINGLE PROBE THAT CAN BE ACTIVELY HEATED OR COOLED AND PUT IN CONTACT WITH THE SKIN. THIS CREATES A TRANSIENT HEAT FLUX, WHICH IS MEASURED AS A FUNCTION OF TIME. TOGETHER WITH A SIMULTANEOUS MEASUREMENT OF THE SURFACE TEMPERATURE, THIS ALLOWS CALCULATION OF THE THERMAL D ...

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THIRTY FOUR MILLION AMERICANS ARE AT LEAST 20 PERCENT OVER THEIR IDEAL WEIGHT. THE EXCESS WEIGHT HAS SERIOUS HEALTH IMPLICATIONS BECAUSE OBESITY HAS BEEN ASSOCIATED WITH PREMATURE MORTALITY. AT ANY POINT IN TIME, AS MANY AS 35 PERCENT OF ADULT AMERICANS ARE ATTEMPTING TO LOWER THEIR WEIGHT AT AN ANNUAL COST OF $5 BILLION. HEALTH INNOVATIONS, INC. WILL DEVELOP A WEIGHT MANAGEMENT PROGRAM THAT RELIE ...

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THIS RESEARCH WILL EXPAND UPON PRELIMINARY STUDIES THAT DEMONSTRATED THE FEASIBILITY OF A SOLID-PHASE, FLOW-THROUGH DEVICE TO CARRY OUT CATALYTIC HYDROGEN TRANSFER REACTIONS. THESE STUDIES USED PALLADIUM-COATED GLASS FIBER FILTERS AS WELL AS SILICA/POLYVINYLCHLORIDE MEMBRANE. PHASE I RESEARCH WILL EVALUATE OTHER SUPPORTS, FOR EXAMPLE, CONTROLLED PORE GLASS AND SILICA/POLYETHYLENE MEMBRANES, AS MAT ...