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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Development of a kit for characterization of cellular energetics in single cells in cell and tissue cultures based on the measurement of the absolute magnitude of the mitochondrial membrane potential

    SBC: Gerencser, Akos            Topic: R41

    DESCRIPTION provided by applicant Altered cellular energetics contributes to human disease in general physiological aging and chronic diseases in particular including cancer neurodegeneration ischemic heart disease and type diabetes Pathological changes affecting the individual may arise only in specific cells of a tissue and potentially in a heterogeneous manner To advance basic resea ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  2. Small, high-affinity ligands for array tomography

    SBC: ARATOME, LLC            Topic: 101

    DESCRIPTION provided by applicant Neurodegenerative diseases are among the most expensive disruptive and least well treated of human maladies arguably because they are not well understood Array tomography AT is a method for tissue imaging with resolution in all three dimensions sufficient to resolve individual synapses and provide quantitative characterization ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Oligonucleotide Inhibition for cardiac regeneration in Ischemia

    SBC: JAAN BIOTHERAPEUTICS LLC            Topic: NHLBI

    PROJECT SUMMARY Ischemic heart disease IHD is the single largest cause of death worldwide A heart attack or myocardial infarction MI results from limitation of coronary blood flow to the heart causing ischemia and ultimately irreversible death of cardiomyocytes The size of a myocardial infarct correlates with the degree of deterioration of heart function compromise of contractile reserve ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Epigenetic Markers and Sustained Cytoprotection for Stroke Treatment

    SBC: ZYMO RESEARCH CORP.            Topic: 101

    PROJECT SUMMARY ABSTRACT Stroke injury is a process that occurs over a long duration with pathologic changes that result in long term neurologic dysfunction For stroke there exists an important need for a strategy that can provide safe and efficacious stabilization to the hypoperfused brain and initialize long lasting endogenous neuroprotection for prevention of long term neurologic dysfunction ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Gold nanoparticle laser warming of cryopreserved zebrafish embryos

    SBC: NANOCOMPOSIX, INC.            Topic: OD

    Project Summary Abstract In the past decade laboratories around the world have produced tens of thousands of mutant transgenic and wild type zebrafish lines for a wide range of genetic and biomedical research Maintaining all of these valuable genotypes is expensive risky and beyond the capacity of even the largest stock centers Cryopreservation of zebrafish sperm eggs and embryos is vital ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Skin Microbiome Editing with Fermentation Initiator

    SBC: Surface Bioadvances, Inc.            Topic: NIAMS

    Abstract Acne dysbiosis is defined as microbial imbalance with the over growth of Propionibacterium acnes P acnes in the acne microbiome We have demonstrated that Staphylococcus epidermidis S epidermidis a probiotic bacterium co existed with P acnes in an acne lesion can exploit the carbohydrate fermentation to produce short chain fatty acids SCFAs and rein in the over growth of P ac ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Breakthrough sub cellular D chemical composition research platform for live cells based on the new invention of nanoscale confocal photothermal IR micro spectroscopy n CPIR

    SBC: Anasys Instruments Corp.            Topic: 100

    Abstract This proposal will lead to a Breakthrough sub cellular D chemical composition research platform for live cells based on the new invention of sub micron confocal photothermal IR micro spectroscopy CPIR Label free sub micron chemical imaging and spectroscopy has long been sought for visualization of biomolecules and materials in complex living systems Many diseases first manifest ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Direct magnetic characterization of individual nanoparticles for optimized diagnostic imaging

    SBC: ODMR Technologies, Inc            Topic: 101

    Project Summary ODMR Technologies Inc and Prof Victor Acostaandapos s group at University of New Mexico UNM are developing a diamond chip platform capable of direct magnetic characterization of individual nanoparticles for optimized diagnostic imaging Our team is a spinoff from academic collaborations in the emerging field of diamond photonic sensors a field we helped create nearly a deca ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Mobile Peer Support for Opioid Use Disorders: Refinement of an Innovative Machine Learning Tool

    SBC: BEACON TECH INC            Topic: R41

    PROJECT SUMMARY This proposal develops a novelartificial intelligenceAIenabledmobile treatment delivery method that fulfills the need for a robustsecuretechnology based peer support platform to support patients with opioid use disordersOUDsThe majority of individuals with OUDs in the United States do not receive any formal substance use treatmentand growing evidence suggests that many OUD patients ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Oral Enzymatic Management of Phenylketonuria

    SBC: ABRI SCIENCE, LLC            Topic: 300

    PhenylketonuriaPKUis a genetic disorder of metabolism characterized by a pathological elevation of phenylalaninePhein the body stemming from a dysfunctional phenylalanine hydroxylase enzymePAHThe resulting high concentrations of Phexcan result in severe intellectual disabilitybehavioral problemsand neurological deficitse gseizuresStrict control of dietary Phe is the primary treatment for PKU curre ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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