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SBC: CUMBERLAND PHARMACEUTICALS, INC. Topic: 300
DESCRIPTION provided by applicant Problem Lower gastrointestinal bleeding is a significant medical problem in the United States accounting for more than hospital admissions and tens of billions of dollars of healthcare spending annually It is common for bleeding from a single site to stop and restart multiple times The three modalities now used to diagnose and locate gastrointestina ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
Development of a kit for characterization of cellular energetics in single cells in cell and tissue cultures based on the measurement of the absolute magnitude of the mitochondrial membrane potentialSBC: Gerencser, Akos Topic: R41
DESCRIPTION provided by applicant Altered cellular energetics contributes to human disease in general physiological aging and chronic diseases in particular including cancer neurodegeneration ischemic heart disease and type diabetes Pathological changes affecting the individual may arise only in specific cells of a tissue and potentially in a heterogeneous manner To advance basic resea ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: AUSCULTECH DX LLC Topic: NHLBI
PROJECT SUMMARY The overall goal of the proposed research and technology transfer effort is to develop a low cost point of care mobile device based technology for automated identification of Stillandapos s murmur the most common innocent benign and harmless heart murmur of childhood This novel technology could reduce the current rate of over a million children unnecessarily referred to pedia ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: MOUNTAINPASS TECHNOLOGY LLC Topic: 102
DESCRIPTION provided by applicant Treatment for depression is a core health disparity for Latinos in the U S Although U S Latinos are more likely than non Hispanic Whites to experience depression Alegria et al U S Latinos are less than half as likely as Whites to receive evidence based care for depression Lagomasino et al Latinos with elevated depressive symptoms are mos ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: SYMBIOTIX BIOTHERAPIES, INC. Topic: 300
PROJECT SUMMARY ABSTRACT Interactions between the gut microbiome and the immune system have been linked to inflammatory bowel disease IBD IBD is a chronic and progressive gastrointestinal disease characterized by uncontrolled activation of the intestinal immune system resulting in severe medical complications affecting over million patients in the United States It is a disease of high u ...STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: On Target Therapeutics, LLC Topic: 106
DESCRIPTION provided by applicant Neuropathic pain is a serious health problem that affects millions of people worldwide and occurs in as much as of the general population The management of neuropathic pain in patients is complex with an estimated of individuals refractory to existing analgesic therapies The aging population the diabetes epidemic and the significant cohorts of can ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: MICROBIOTIX, INC. Topic: R
DESCRIPTION provided by applicant Ebola EBOV and Marburg MARV viruses belong to the family Filoviridae and can cause fatal hemorrhagic fevers characterized by widespread tissue destruction with an incubation period of days Because of the safety concerns these viruses are designated as biosafety level agents Currently there is no effective vaccine or therapeutic treatment against f ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: ARISAN THERAPEUTICS INC Topic: NIAID
Project Summary Linking infectious agent diagnostics to clinical decision making at the point of care requires a fast highly sensitive and simple to use method that takes into account the infrastructure and workflow in clinical settings of both developing and developed regions In addition being able to distinguish among multiple potential infectious pathogens in a single test is of great impor ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: Medosome Biotec, LLC Topic: NIAID
DESCRIPTION provided by applicant Adeno associated virus AAV is a non pathogenic human parvovirus and recombinant AAV vectors have gained significant attention owing to their safety and in some cases clinical efficacy in a number of Phase I II clinical trials However relatively large vector doses are needed to achieve clinical efficacy and such high doses can lead to host immune respon ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: AFASCI, INC. Topic: NIDA
DESCRIPTION provided by applicant The abuse of illicit drugs such as cocaine marijuana and heroin remains a critical public health concern throughout the country and is associated with staggering economic and social consequences Cocaine remains the most frequently recorded illicit drug in emergency hospital visits and the leading cause of drug related deaths in the United States Since as hi ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health