Award Data

The focus of this STTR phase I component is on proof-of-concept studies demonstrating applicability of technical approaches for identificationof circulatory diagnostic markers for infectious disease. Therefore, the primary objective of this project is to determine feasibility of one suchtechnical approach called Proteomics-based Expression Library Screening (PELS), for identification of pathogen-d ...

There are currently no vaccines or therapeutics available for Marburg Virus Disease (MVD). Given the specter of weaponization and the terriblemorbidity and high mortality rate of MVD, this represents a critical threat to the operational readiness of the Warfighter. While traditionalvaccines have proven to be a huge contribution to public health, they do have some limitations especially in the cont ...

Recreational drug use by military personnel can impact soldier preparedness and performance especially in difficult and demanding environments. One challenge for monitoring illicit drug use is that current tests rely on the identification of specific chemical structures. Small variants in the chemistry of a drug can evade detection. In this Phase I SBIR, we will develop a lateral flow test that ...

Layer-by-layer additive manufacturing (AM) has been flourishing. The next generation AM will be hybrid which includes 3D AM printer, CNC mill, micro-milling capability, CAD/CAM, pick-and-place tool and many interchangeable print engines. In other words, this next generation of printers will be a completely computer integrated system. For the last four years, we have been integrating an industr ...

Historically, the monitoring and detection of biological threats has been carried out via the deployment of high sensitivity / high complexity monitoring nodes to insure high probability of detection and low false alarm rate. Unfortunately, this detection strategy has inherent limits with respect to coverage and response due to its high deployment/support costs, mandating a new approach to environ ...

We propose to develop highly-sensitive low size, weight, and power (SWaP) chip-scale mid-infrared integrated-optic sensors for trace gas measurements, We will combine Tunable Diode Laser Spectroscopy (TDLAS) detection techniques with narrow-linewidth fast-tuning Distributed Feedback (DFB) Quantum Cascade and Interband Cascade Lasers (QCLs and ICLs) to create a platform for a family of sensors, ea ...

Near-Field Scanning Microwave Microscopy (SMM) is a technique relying on a raster scan of a microwave probe across a sample surface, while measuring its reflected microwave signal. The existing technologies are limited to the surface analysis, and are not compatible with liquid environment. These limitations are addressed by the proposed wideband 3D tomography SMM with sub-surface analysis capabil ...

Scanning microwave microscopy (SMM), capable of quantitatively measuring local electromagnetic properties at submicron length scales, has been widely used in semiconductor industry, materials science, physics, biology and other fields of science and technology. In particular, it offers the unique capability of penetrating into the sample-under-test in a non-invasive and non-contacting manner. Howe ...

This work seeks to demonstrate the wide spread applicability of Geometric Multi-Resolution Analysis (GMRA) to uncover low dimensional structure in large volume and high dimensional data sets. The objective is to show that the GMRA approach applies naturally to a variety of data types and to demonstrate its practical implementation in a scalable data intensive computing environment. The GMRA appr ...

Waste generation at forward bases creates significant challenges; its disposal presents an economic cost with no direct benefit and its accumulation or burning is a health hazard. The bioconversion of waste into useful compounds could save thousands annually for every soldier and tens of millions in capital expenditure. However, widespread adoption is impeded by low conversion efficiency. We propo ...