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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Development of novel, targeted small molecule inhibitors of DNA repair in high unmet need tumors-TNBC

    SBC: DNATWO, Inc.            Topic: NCI

    DNATWO, Inc. was founded out of Caltech to develop small molecule drugs targeting a new cancer target, DNA2, to treat triple-negative breast cancer (TNBC). We have spent decades unraveling the role of the DNA2 ATP-motor driven nuclease activity in relieving replication stress at the replication fork and carrying out repair at forks collapsed to double strand breaks (DSBs). Our scientific premise i ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  2. Clinical Decision Support System to Optimize Neonatal Nutrition and Growth

    SBC: Medical Predictive Science Corporation            Topic: NICHD

    Project Summary/Abstract: Clinical Decision Support System to Optimize Neonatal Nutrition and Growth Nutrition, defined as energy, macronutrients (protein, fat, and carbohydrates), and micronutrients (e.g., electrolytes), is a critical feature of care for preterm infants in the neonatal intensive unit (NICU). Inadequate nutrition is associated with growth and neurodevelopmental impairment, and inc ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  3. Development of negative allosteric modulators of the mu-opioid receptor for the management of opioid use disorder

    SBC: ELEVEN THERAPEUTICS CORP            Topic: NIDA

    Abstract There is a significant need for new treatments for opioid use disorder (OUD) to manage patients abusing heroin, fentanyl, oxycodone and related drugs. Buprenorphine and methadone are both effective medications for OUD but are agonists with potential for abuse and diversion, and with methadone the risk of respiratory depression and overdose death. Moreover, these compounds are not effectiv ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  4. Developing generalized engineering tools to create enhanced phage therapy for the clinic and commercialization

    SBC: FELIX BIOTECHNOLOGY INC            Topic: NIAID

    ABSTRACT Antibiotic-resistant infections are a major public health threat in the U.S. and globally, with Pseudomonas aeruginosa (Pa) being one of the top pathogens of concern. Phage therapy is a promising approach to treat these infections, with benefits of species-targeted activity that spares the host microbiome, an ability to penetrate biofilms and kill metabolically-inactive persister cells, a ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  5. Nanoimmunotherapy for chronic immune-mediated diseases

    SBC: GENERAL NANOTHERAPEUTICS LLC            Topic: NIAID

    ABSTRACT Current pharmaceutical agents that are used for the treatment of immune-mediated inflammatory conditions including autoimmune diseases generally do not lead to remission and frequently carry toxic side effects. Here we propose a strategy that can harness the capacity of the immune system to induce immunoregulatory response that can suppress immune hyperactivity and chronic inflammation in ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  6. A web-based platform to support team-based genome diagnostics

    SBC: FRAMESHIFT LABS INC            Topic: 172

    Summary/Abstract Genomic sequencing is rapidly becoming a standard tool in diagnosing complex diagnostic cases, especially in critically ill newborns, and patients suffering from rare diseases. Current programs focused on addressing these cases utilise a team-based approach to identify, interpret and evaluate a patient’s genetic variants. These diverse teams include bioinformaticians, medical ge ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  7. CCR5 immunotoxins as components of HIV cure regimens

    SBC: TENDEL THERAPIES INC            Topic: NIAID

    This project will establish proof-of-concept for CCR5 immunotoxins as HIV reservoir-depletion agents for use in cure strategies. HIV cure and remission strategies require elimination or reduction of the HIV reservoir. Approaches to reservoir reduction pursued by other groups include gene editing, i.e., direct removal of integrated provirus; latency reversal and an accompanying “kill” strategy; ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  8. High-speed, portable reflectance confocal microscope (pRCM) for imaging skin cancer

    SBC: ARGOSMD, INC.            Topic: 102

    Project Summary/Abstract The current standard of care for skin cancer diagnosis, biopsy, is invasive, slow, and burdensome in cost. Skin cancer is the most commonly diagnosed cancer in the US. Biopsy of suspicious skin lesion is the key step of skin cancer diagnosis. 15-20 million skin biopsies are performed in the US annually. Once biopsied tissue is removed from a patient, the biopsy specimen is ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  9. System for documenting and tracking skin lesions

    SBC: Lumo Imaging LLC            Topic: NIBIB

    Project Summary The objective of this STTR proposal is to develop a system for longitudinally tracking the locations and morphologic changes to all Pigmented Skin Lesions on the patient’s body. The proposed software will build on a previously developed Total Body Photography (TBP) system, called Lumo Scanner, that can provide unprecedented resolution across the entire body surface. Skin cancers, ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  10. Developing novel technologies to monitor nociception and opioid administration during surgery and general anesthesia in order to minimize post-operative opioid requirements

    SBC: PASCALL Systems, Incorporated            Topic: NIDA

    PROJECT SUMMARY In light of the opioid crises, minimizing postoperative pain and postoperative opioid requirements to reduce chronic opioid dependency among surgical patients have become major concerns for surgeons and anesthesiologists. Effective intraoperative nociception control can mitigate these concerns. Unfortunately, existing nociceptive monitoring tools use indicators that are inherently ...

    STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
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