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SBC: TENDEL THERAPIES INC Topic: NIAID
This project will establish proof-of-concept for CCR5 immunotoxins as HIV reservoir-depletion agents for use in cure strategies. HIV cure and remission strategies require elimination or reduction of the HIV reservoir. Approaches to reservoir reduction pursued by other groups include gene editing, i.e., direct removal of integrated provirus; latency reversal and an accompanying “kill” strategy; ...STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
Preclinical testing of a 3D printed external scaffold device to prevent vein graft failure after coronary bypass graft surgerySBC: BIOGRAFT, INC. Topic: NHLBI
Saphenous vein graft (SVG) failure following coronary artery bypass grafting (CABG) is a critical clinical problem, with recent studies revealing that as many as 25% of vein grafts develop stenosis within 12-18 months after surgery, and up to 50% of grafts occlude within 5-10 years. CABG surgery is the gold standard treatment for patients with severe multi-vessel disease, with over 370,000 procedu ...STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
SBC: L2 DIAGNOSTICS LLC Topic: NIAID
SUMMARY Arboviruses present a constant threat to human and animal health worldwide. They are transmitted by hematophagous arthropods, primarily mosquitoes. One of them, Aedes aegypti, is the primary vector of several widely spread arboviruses such as Zika, dengue and West Nile viruses, and for most of them, human-licensed vaccines do not exist or are suboptimal. These pathogens are transmitted int ...STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
SBC: MelioLabs Inc. Topic: NICHD
PROJECT SUMMARY Since 2014, Congenital Syphilis (CS) cases in the United States, caused by the transplacental transmission of the bacterium Treponema pallidum from mother to child, have increased at an alarming rate. Targeted surveillance studies indicate a rise andgt;185% from 2014 to 2018 alone. Women who acquire syphilis within 4 years of pregnancy will transmit the infection to 80% of their fe ...STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
SBC: INFRATRAC INC Topic: NIAID
Precise, customizable drug delivery remains a long-term goal, for HIV in particular, as such technologies would allow therapies tailored to a patient’s biological makeup and potentially improve adherence. Extended-release methods address part of the issue, but face limitations. A novel drug delivery system could offer better pediatric dosing, via both oral and new routes of administration. Exist ...STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
SBC: MS Technologies Corporation Topic: NIDCR
Dental CBCT is a 3D imaging modality widely adopted to help dentists detect and diagnose jaw lesions. Due to minimum information loss (compared to conventional 2D radiography) and low radiation exposure (compared to conventional CT), it has become the “go-to” radiographic technique in various dental fields. Gaps: Accompanying the clear benefits of dental CBCT is an overwhelming amount of 3D da ...STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
SBC: MODALITY.AI , INC Topic: NIDCD
PROJECT SUMMARYAmyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease resulting in the progressive loss of limb, trunk, and head and neck (bulbar) motor function and is the most common adult-onset motor neuron disease. The disease is characterized by significant across-patient heterogeneity in the onset region and in pattern and progression rate, making early and accurate diagnos ...STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
SBC: Lumo Imaging LLC Topic: NIBIB
Project Summary The objective of this STTR proposal is to develop a system for longitudinally tracking the locations and morphologic changes to all Pigmented Skin Lesions on the patient’s body. The proposed software will build on a previously developed Total Body Photography (TBP) system, called Lumo Scanner, that can provide unprecedented resolution across the entire body surface. Skin cancers, ...STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
SBC: EXBAQ LLC Topic: NIAID
PROJECT SUMMARY/ABSTRACT Two million Healthcare Associated Infections (HAIs) occur per year in the US, killing rt90,000 patients and costing ~$50-100 billion (adjusted by CPI to 2020 dollars). HAIs are the 6th leading cause of death in the US, ahead of diabetes and kidney disease. Reducing HAIs is a top priority of the US Department of Health and Human Services1 and experts have called for novel s ...STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
Translating an In-Person Brief, Bystander Bullying Intervention (STAC) to a Technology-Based- Phase IISBC: KLEIN BUENDEL, INC. Topic: 102
While studies support the efficacy of comprehensive, school-wide interventions in reducing bullying, these types of programs can require significant time and financial resources for implementation, resulting in barriers to providing school-based bullying prevention, especially in low-income and rural communities. Additionally, although training bystanders to act as “defenders” on behalf of tar ...STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health