Award Data

PROJECT SUMMARY Our Small Business Innovation Research initiative is focused on offering novelcost effective clinical equipment and techniques that significantly impact and advance diagnostics and therapeutic monitoring of a variety of cancersHyperE proposes to design and produce the first commercial ready parahydrogen induced polarizationPHIPinstrument to facilitate the breakthrough of PHIPan eme ...

Abstract The number of knee joint replacement procedures has increased exponentially over the last decade with no indications of slowing downWhile sustaining highly successful outcomesimplant failures still occur and the annual incidence of knee revision surgeries remain steady aroundof primary surgeriesImplant loosening has been cited as the dominant cause of long term failureLooseninghoweveris o ...

ABSTRACT Mobile App Promoting Sexual Health for Young Black Men who Have Sex with Men Men who have sex with men, and particularly Black men who have sex with men (BMSM) have been disproportionately affected by HIV/AIDS since the beginning of the epidemic, but in recent years the impact of HIV among young Black men who have sex with men (YBMSM) has escalated rapidly. More new HIV infections occur a ...

Project Summary This Phase II SBIR project will developoptimizetestcommercializeand take to market an inhalation chamber that mimics the e cigarette technology being used by human usersand being popularized by ecigarette manufacturers and advertisersE cigarette use and abuse is a major public health concernbut little is known about the biology underlying e cigarette use and negative health impact ...

Project SummaryInflammatory bowel diseaseIBDaffects millions worldwideIBD can be divided into Crohn s DiseaseCDand Ulcerative ColitisUCboth of which are characterized by chronic inflammation in the gutleading to diarrheaulcerationbleedingand in many cases tumorsCurrentlymild to moderate IBD is treated orally with aminosalicylatesASAwhile more severe cases require the use of systemic immunosuppress ...

ABSTRACTDiabetes Mellitus is a serious chronic disease in which the physiological homeostatic controls in the body becomes less responsive to changing blood glucose levelsIn Type II diabetes the body makes little or no insulinthe hormone responsible for reducing blood glucose levelsor the mechanisms down stream of insulin become unresponsive to the insulin producedType II diabetes is the most prev ...

PROJECT SUMMARY The development and commercialization of microfluidic based single cell RNA seq platforms has enabled the transcriptomes of thousands of single cells to be profiled at a timeallowing researchers to differentiate between cell types and study cell fate decisionsHowevernone of these new technologies can correlate single cell genetic or epigentic variations with gene expression at high ...

PROJECT SUMMARY ABSTRACTMultifunctional antibody therapy for acute myocardial infarction Patients with acute coronary syndromeACSsuffer from a range of acute myocardial ischemic statesThrombolysis and percutaneous interventionPCIare used to reperfuse the ischemic tissue and stabilize damage caused by infarctionAfter acute myocardial infarctionAMIischemic tissues undergo cell death from necrosis an ...

Streptococcus pneumoniaethe pneumococcusis the most common cause of severe pneumoniaanddespite the existence of licensed vaccinesannually kills half of a million children under five years old worldwidePneumococcal conjugate vaccinesPCVshave the intrinsic disadvantage of a limited number of serotypes against which they provide protectionresulting in disease due to serotype replacement that reduces ...

Project Summary andampAbstract Industrial processes produce difficult to treat wastewater containing environmental contaminants in the form of dissolved metalsmany of which pose a potential health hazard to plantsanimalsand humansExamples include mining industry effluentswastewater treatment effluents and landfill leachatesIn many casesthese waste streams cannot be treated cost effectivelyConseque ...