Award Data

DESCRIPTION (provided by applicant): While there is no doubt smoking is a direct causative factor underlying the development of lung cancer, not every smoker develops lung cancer. In fact, only 10-15% of smokers develop this disease, indicating that otherfactors make certain individuals more susceptible to cancer. A number of single nucleotide polymorphisms are known to correlate with the developm ...

Project Summary AbstractThe recent rapid expansion of genomic data greatly contributes to the understanding of disease development and progressionTo translate these genetic discoveries into clinical applicationswe need to develop therapeutic platforms that can specifically modulate the expression of disease related genes in vivoSmall RNAssuch as microRNAs and siRNAs function in messenger RNA silen ...

Evolution of an Adaptable Prosthetic Foot Design for Normalization ofBiomechanics During Community Participation Summary/AbstractThe vision of this project is to improve the functional physical mobility of people with lower extremity amputations especially on uneven ground, side-slopes or when foot placement varies from side-to-side. People with amputations will be enabled to confidently participa ...

ABSTRACT: The objective of this effort is to develop innovative methods for deriving a sparse set of physical target features that can be used for exploitation of air to ground signature data collected from sensor systems including electro-optical, infrared, and laser radar. Current classification methods require near exact replication of the original imaging parameters, or extensive modeling in ...

Project SummaryUltrasonic vocalizations (USVs) are known to reflect emotional processing, brain neurochemistry and brain function - key observations in animal model studies. Collecting and processing USV data is time-intensive, manual, and costly. Most importantly, it limits researchers’ ability to employ fully effective, and nuanced experimental designs, and is a barrier to entry for other rese ...

An eye-safe optically pumped laser based on a gas-filled hollow optical fiber will be demonstrated to lase at both near infrared (IR) and mid IR wavelengths. These lasers will be the first in a new class of IR lasers, based on the combination of hollow-f

An eye-safe optically pumped laser based on a gas-filled hollow optical fiber will be demonstrated to lase at both near infrared (IR) and mid IR wavelengths. These lasers will be the first in a new class of IR lasers, based on the combination of hollow-f

This Phase I STTR program seeks a new fabrication method to produce stronger (>100 kpsi) and tougher (>10 MPa m1/2) ultra high temperature Ta-Hf-C-based composites (UHTC) with an outstanding oxidation resistance for use as thermal protection systems for hypersonic applications, as well as for advanced rocket nozzle throat components. UES will apply a novel "Top Down" approach to control the micro ...

There is a DoD need for the development of robust sensors to obtain temporally and spatially resolved surface temperature and heat flux measurements on test articles in blowdown and continuous hypersonic wind tunnels. These micro-heat flux sensors are required in order to better understand the state of the boundary layer of a hypersonic vehicle; to better understand boundary layer instabilities; a ...

Accurate knowledge of heat flux is critical in assessing the design, performance, and survivability of hypersonic flight vehicles. Despite decades of research and testing, much is still unknown regarding hypersonic instabilities and transition mechanisms that define the state of the boundary layer. While the existence of these features is known, the ability to accurately measure them remains a cha ...