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THE ULTIMATE OBJECTIVE OF THIS RESEARCH IS TO DEVELOP A NOVEL TREATMENT FOR DIABETES BASED ON THE ENHANCEMENT OF INSULIN ACTION THROUGH THE INHIBITION OF AN INSULIN RECEPTOR-SPECIFIC PHOSPHOTYROSINE PHOSPHATASE (PTPASE). PHOSPHORYLATION OF THE INSULIN RECEPTOR BETA-SUBUNIT, IN RESPONSE TO INSULI BINDING, HAS BEEN CORRELATED WITH ACTIVATION OF THE PLEIOTROPHIC INTRA- CELLULAR INSULIN SIGNAL. MODULA ...

CILIARY NEUROTROPHIC FACTOR (CNTF) IS A POTENT POLYPEPTIDE HORMONE WHOSE ACTIONS APPEAR TO BE RESTRICTED TO THE NERVOUS SYSTEM. CNTF HAS BEEN OBSERVED TO PROMOTE SURVIVAL, NEUROTRANSMITTER SYNTHESIS AND NEURITE OUTGROWTH IN VARIOUS SYMPATHETIC, SENSORY AND PARASYMPA- THETIC NEURONS AT FEMTOMOLAR TO LOW PICOMOLAR CONCENTRATIONS. THUS CNTF HAS POTENTIAL CLINICAL APPLICATIONS IN THE TREATMENT OF A NU ...

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PHASE I PROPOSES TO GATHER THE DATA AND DISCRIPTIVE INFORMATION FOR A 28-SHOT SET OF EXPERIMENTS MADE IN THE EARLY 1970'S TO MEASURE HIGH OVERPRESSURE AIRBLAST FROM 8-LB CHARGES OF PBX-9404, TO PREPARE A WORK PLAN AND PROCEDURES FOR COMPLETING THE DATA PROCESSING FROM THE EXPERIMENTS, CHECKOUT THE PROCEDURES WITH SAMPLE ANALYSES, AND TO PREPARE A COST ESTIMATE FOR PHASE II. THE COMPLETION OF PHASE ...

A PHASE I SBIR STUDY IS PROPOSED TO DETERMINE ANALYTICALLY THE FEASIBILITY OF MEASURING THE FREE-AIR (UNREFLECTED) AIRBLAST WAVEFORMS FROM A NUCLEAR BURST IN AN UNDERGROUND CAVITY. SUCH DATA WOULD BE USEFUL FOR EVALUATING MEASUREMENTS TO BE MADE OF THE AIRBLAST IN THE REGION OF BLAST RELECTION FROM THE CAVITY FLOOR AND WALL. THE STUDY WILL CONSIDER WELL-PROVEN PIEZOELECTRIC AND RESISTIVE TECHNIQUE ...

TACTICAL MISSILE DEVELOPMENT REQUIRES NOT ONLY MISS DISTANCE, VELOCITY AND TIME OF CLOSEST APPROACH BUT ALSO MISSILE ATTITUDE AND TRAJECTORY DURING INTERCEPT. CARTWRIGHT ELECTRONICS, INC. (CEI) HAS DEVELOPED SCALAR SCORING SYSTEMS WHICH HAVE DEMONSTRATED ACCURACY AND TARGET RESOLUTION COMPATIBLE WITH VECTOR SCORING REQUIREMENTS. USE OF SUBSCALE TARGETS SUCH AS THE EON-345 IMPOSES SEVERE ANTENNA SP ...

DEVELOPMENT OF EFFICIENT, LONG-LIVED CATALYSTS FOR SELECTIVE METATHESIS OF FUNCTIONALIZED OLEFINS WILL ENABLE PREPARATION OF BOTH NEW ORGANIC COMPOUNDS AND THOSE THAT CAN NOT NOW BE PREPARED IN USEFUL QUANTITIES BY EXISTING METHODS. THESE ARE COMPOUNDS WHICH WILL, BECAUSE OF THE VARIETY OF FUNCTIONAL GROUPS THEY CONTAIN, FIND APPLICATION AS INTERMEDIATES IN MANY APPLICATIONS OF COMMERCIAL INTEREST ...

THIS PROJECT IS USING A NOVEL APPROACH TO DEVELOP HIGH TEMPERATURE ALUMINUM ALLOYS THAT HAVE EXCEPTIONAL STRENGTH AND CORROSION RESISTANCE. CONTROLLED CONSOLIDATION CRYSTALLIZATION OF RECENTLY DISCOVERED ULTRA-HIGH STRENGTH (1120 MPA) DUCTILE GLASSY ALUMINUM ALLOY IS BEING CARRIED OUT TO OBTAIN A DUAL-PHASE STRUCTURE WITH AN EQUIAXED ULTRAFINE GRAIN MATRIX, A CONDITION CONDUCIVE TO SUPERPLASTIC FO ...

CURRENT PROCESSING SCHEMES OF COLD FORGING AND MACHINING TO FORM HEAVY METAL SHAPE CHARGE LINERS REQUIRE HOURS OF MACHINING, RESULTING IN ALMOST 90% OF THE MATERIAL WASTED, AND LEADS TO SIGNIFICANT COST PENALTIES. THE FEASIBILITY OF A NOVEL NEAR-NET SHAPE PROCESSING SCHEME WILL BE EVALUATED IN PHASE I. THIS PROPOSED APPROACH HAS THE POTENTIAL TO INCREASE PERFORMANCE TO DENSITY LAW LEVELS, WHILE RE ...

NASA IS INTERESTED IN NEW ALUMINUM ALLOYS OF NON-EQUILIBRIUMCHEMISTRIES WITH THE OBJECTIVE OF INCREASING THE UPPER-USE TEMPERATURE BY 200F. PRIOR ART HAS DEALT WITH THE USE OF RAPID SOLIDIFICATION TO FORM FINE-GRAINED CRYSTALLINE ALLOYSBASED ON AL-FE-V-SI, AL-FE-CE, AND AL-FE-MO-V. ALTHOUGH THESE ALLOYS HAVE SHOWN PROMISE IN IMPROVING USE TEMPERATURE, SIGNIFICANT FURTHER IMPROVEMENT COULD BE MADE ...