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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Macromolecule Crystallization Screening Results Analysis

    SBC: iXpressGenes, Inc.            Topic: 100

    Project Summary Crystallization followed by subsequent structure determination is a major step in understanding the structure function relationship of macromolecules Understanding macromolecule structure has become a key part in the development of new pharmaceuticals and is a major area of NIH research Crystallization however is also the rate limiting step despite technological efforts to a ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  2. Trans‐nasal delivery of chemotherapy to glioblastoma using magnetic nanoparticles and magnetic focusing

    SBC: WEINBERG MEDICAL PHYSICS, INC.            Topic: 102

    Abstract Glioblastoma multiforme GBM is the deadliest form of brain tumor The current treatment includes a combination of surgical resection chemotherapy radiation and electrical disruption of mitosis has only extended survival to approximately to years Preliminary pre clinical findings suggest the potential effectiveness of the candidate drug cyclopamine However the drug is toxic to ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Production of Inactivated Vaccines Using Supralethal Irradiation

    SBC: BIOLOGICAL MIMETICS, INC.            Topic: DTRA14B002

    The discovery and commercial development of licensed vaccines often take many years of research followed by years of pre-clinical and clinical development. We propose to assess the feasibility of using a novel irradiation-inactivation technology to develop vaccines more rapidly. The technology utilizes a manganese-peptide complex to protect antigenic proteins from ionizing radiation while allowing ...

    STTR Phase II 2017 Department of DefenseDefense Threat Reduction Agency
  4. Intra procedure Deformable Ultrasound MRI Fusion for Prostate Biopsies

    SBC: ZMK Medical Technologies, Inc.            Topic: 102

    This Phase II proposal is a continuation of our successful Phase I grant whose overarching goal is to develop a more robust and accurate method for the deformable fusion of pre operative magnetic resonance images MRI and intra procedure trans rectal ultrasound TRUS images to guide prostate biopsy Prostate cancer is a major cause of death in the U S and biopsy is the gold standard for its dia ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  5. Broadly Protective Bispecific Antibodies for Treatment of Ebola Virus Disease

    SBC: Integrated Biotherapeutics, Inc.            Topic: NIAID

    PROJECT SUMMARY The family of Filoviridae consisting of five ebolaviruses and two marburgviruses are causative agents of severe hemorrhagic fever with human case fatality rates ofTheepidemic of Ebola virus disease in West Africa was unprecedented both in geographic scope and size and highlighted the extent of the threat filoviruses could pose to global public health and the urgent need for develop ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  6. SA FasL engineered human islets as a novel product for the treatment of type diabetes

    SBC: FasCure Therapeutics LLC            Topic: NIDDK

    PROJECT SUMMARY Type diabetes T D is a chronic autoimmune disorder that affects of population worldwide Exogenous insulin treatment is the standard of care for T D but often negatively affects the quality of life and is ineffective in preventing recurrent hyperglycemia episodes and chronic complications Recent studies show that human islet allografts can restore long term normoglycemia ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Assessing Skills and Treatment Progress in Basic Communicators of All Ages The Basic Social and Communication Behavior Scales BSCBS Phase I

    SBC: PAUL H BROOKES PUBLISHING CO., INC.            Topic: NIDCD

    Project Summary Abstract Effective communication intervention depends on reliable tools for identifying communication concerns and tracking changes in skills Established tools for detecting and tracking skills in early intentional communicators i e directing a behavior such as reaching toward an adult to convey a message involve communication temptations and assessing a wide variety of child ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Urine Diagnostics for Aspergillosis

    SBC: PEARL DIAGNOSTICS, INC.            Topic: NIAID

    Invasive aspergillosisIAcontinues to cause morbidity and death in medically immune compromised patientslargely because we lack sensitive diagnostic tests that are easy to use during high risk periodsWe discovered that fungal galactofuranose containing antigens are excreted in urine of infected animals and peopleusing a novel monoclonal antibodymAbIn a phase I STTRwe engineered a lateral flow devic ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  9. A Transparent Surgical Mask to Improve Patient Caregiver Communication Minimize Errors and Increase Patient Satisfaction

    SBC: FaceView Mask, LLC            Topic: 600

    PROJECT SUMMARY Hearing loss innate and acquired occurs in over million Americans and globally in over million people To compensate many with hearing impairment rely on the combination of audio information and visual cues from the face cheeks nose and eyes to facilitate speech understanding In healthcare settings this important visual communication is severely hindered by the ubi ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Development of the first-in-class novel dual PI-3K/BRD4 inhibitor SF2523

    SBC: SignalRx Pharmaceuticals Inc.            Topic: 102

    There is an unmet need to inhibit the key cancer promoting transcription factor MYCboth c MYC and MYCNthat act downstream of many cell receptors and signal transcription pathways to activate genes for cancer cell resistance and tumor growthTo datesmall molecule inhibitors of MYC have remained elusiveIn our Phase I STTRCAwe developed a lead compoundSFwhich displays potent orthogonal inhibitory acti ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
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