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SBC: Cavatar LLC Topic: NCI
PROJECT SUMMARY Early cancer detection and diagnosis are critical for patient survival and treatment successFor the imaging of breast and other solid tumorsthe diagnostic power of advanced imaging techniques such as SPECT could benefit tremendously from improved contrast agents that rapidly and selectively accumulate in tumor lesions and produce high tumor to background signal ratiosWe are develop ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
Trans‐nasal delivery of chemotherapy to glioblastoma using magnetic nanoparticles and magnetic focusingSBC: WEINBERG MEDICAL PHYSICS, INC. Topic: 102
Abstract Glioblastoma multiforme GBM is the deadliest form of brain tumor The current treatment includes a combination of surgical resection chemotherapy radiation and electrical disruption of mitosis has only extended survival to approximately to years Preliminary pre clinical findings suggest the potential effectiveness of the candidate drug cyclopamine However the drug is toxic to ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: WinSanTor, Inc. Topic: O
PROJECT SUMMARY Chemotherapy induced peripheral neuropathy CIPN is a debilitating complication that can arise from use of a number of chemotherapeutics and which limits both the dose and duration of cancer treatments with these agents Up to of cancer patients treated with chemotherapy describe some form of CIPN with sensory neuropathy being dominant Symptoms vary from tingling and numbne ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: FasCure Therapeutics LLC Topic: NIDDK
PROJECT SUMMARY Type diabetes T D is a chronic autoimmune disorder that affects of population worldwide Exogenous insulin treatment is the standard of care for T D but often negatively affects the quality of life and is ineffective in preventing recurrent hyperglycemia episodes and chronic complications Recent studies show that human islet allografts can restore long term normoglycemia ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
Enabling point of care molecular diagnostics by developing an adaptive PCR instrument and on demand kit reagentsSBC: BIOVENTURES, INC Topic: 172
Because of its high sensitivity polymerase chain reaction PCR is the gold standard for the diagnosis of many infectious diseases but generally only implemented in well equipped laboratories One of the major roadblocks for expanding PCR to point of care markets is the lack of simple robust single tube PCR designs which preserve its laboratory based high sensitivity and specificity In this F ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: VioMedix, LLC Topic: 102
PROJECT SUMMARYABSTRACTBreast cancer is the second leading cause of death in females with cancerInapproximatelynew cases of invasive breast cancer were diagnosedwhere an estimate ofwas expected to succumb to their diseaseIt is estimated that one in eight women will develop breast cancer in their lifetimeBreast cancer is classified into subtypes based on the expression of estrogen receptorERprogest ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: Surface Bioadvances, Inc. Topic: NIAMS
Abstract Acne dysbiosis is defined as microbial imbalance with the over growth of Propionibacterium acnes P acnes in the acne microbiome We have demonstrated that Staphylococcus epidermidis S epidermidis a probiotic bacterium co existed with P acnes in an acne lesion can exploit the carbohydrate fermentation to produce short chain fatty acids SCFAs and rein in the over growth of P ac ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: L2 DIAGNOSTICS LLC Topic: NIAID
ABSTRACT Borrelia miyamotoi is a tick transmitted spirochete recently shown to cause infection and disease in the United StatesEurope and AsiaA member of the relapsing fever group of Borreliathis pathogen has been proven to cause most commonly a nonspecificflu like illness with feverfatiguemyalgiaand headacheDisease can be particularly severe and involve the central nervous system in immunocomprom ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: New England Discovery Partners, LLC Topic: NIAID
AbstractMosquito borne flaviviruses cause disease worldwidewith members such as dengue virusDENVZika virusZIKVand west nile virusWNVinfecting more thanmillion individuals annuallyThe availability of small molecule antivirals that reduce flavivirus infection therefore could have an immediate and substantial impact on public health programs that seek to improve outcomes for populations infected with ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: Cavatar LLC Topic: 102
Abstract Caveolae at the endothelial cells surface can selectively rapidly and actively pump targeted antibodies out of the bloodstream and into underlying tissue in vivo even when they are conjugated to high molecular weight cargo Based on this exciting recent discovery we also found that caveolae pumping system enables unprecedented tumor specific targeting and penetration Taken together ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health