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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Computer-based Learning to Enhance ADRD Care in Prison: Just Care for Dementia

    SBC: KLEIN BUENDEL, INC.            Topic: R

    Project Summary/Abstract U.S. prison systems face sharply increased demands in caring for older people living in prisons. Alzheimerandapos;s Disease and related dementias (ADRD) are age-related diseases. Prison populations are over- represented by minority populations who experience disparities in prevalence and incidence of dementia. Prison health, social, and security staff perceive they lack th ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  2. High-speed, portable reflectance confocal microscope (pRCM) for imaging skin cancer

    SBC: ARGOSMD, INC.            Topic: 102

    Project Summary/Abstract The current standard of care for skin cancer diagnosis, biopsy, is invasive, slow, and burdensome in cost. Skin cancer is the most commonly diagnosed cancer in the US. Biopsy of suspicious skin lesion is the key step of skin cancer diagnosis. 15-20 million skin biopsies are performed in the US annually. Once biopsied tissue is removed from a patient, the biopsy specimen is ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  3. Leveraging platelet signal transduction for personalized antiplatelet therapy

    SBC: PlateletDiagnostics, LLC            Topic: NHLBI

    Project Summary/Abstract Platelet-mediated thrombosis causes both coronary arterial disease (CAD) and stroke, the first and fifth most common causes of mortality in the US. Antiplatelet agents, typically aspirin and/or clopidogrel, significantly improve survival in patients with CAD or stroke and have remained a mainstay of treatment for more than two decades. Yet despite the consensus that platel ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  4. Glycoengineering of CHO cells to express recombinant alpha-1 antitrypsin

    SBC: NEUIMMUNE BIOLOGICS, INC.            Topic: NHLBI

    ABSTRACTAlpha-1 antitrypsin (A1AT) is well-established as a biotherapeutic used for the treatment of alpha-1 antitrypsin deficiency, and shows promise for treating a variety of other diseases. However, A1AT augmentation therapy carries unnecessary risk since it relies upon the weekly transfusion of plasma-derived product, which presents supply chain and contaminant risks. This could be remedied wi ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  5. The First Non-Surgical Anti-Stomal Prolapse Medical Device to Treat and Prevent Stomal Prolapse

    SBC: PEDIATRIC MEDICAL DEVICE COMPANY, LLC            Topic: 300

    ABSTRACT Intestinal stomas such as ileostomies and colostomies are openings of the intestinal tract surgically exteriorized onto the abdominal surface to divert enteric content away from distal cancer, obstruction, inflammation, and infection 5. In the US alone, about 1.5 million people have stomas14. Prolapse, or protrusion, of the bowel through the stoma is a common complication that can cause p ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  6. Development of a Bio-tissue Oxygenation Nanophosphor Enabled Sensing (BONES) system for Quantifying Hypoxia in Bone Marrow

    SBC: SIGRAY, INC.            Topic: 400

    Project Summary/Abstract Low oxygen (hypoxic) environments are known to be important for maintaining the small number of adult stem cells in the human body, such as in bone marrow. These conditions are also believed to enable dormant cancer cells to survive and metastasize years or decades after the original tumor has been destroyed and the reason why bone marrow is one of the most common sites of ...

    STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  7. New Agents for the Treatment on Mycobacteria Avium Infections

    SBC: Quercus Molecular Design, LLC            Topic: NIAID

    Abstract: Non-Tuberculosis Mycobacteria (NTM) are responsible for widespread, life threatening infections of the lungs, skin, lymphatic and hematological systems. The rapid, global spread of resistant organisms has significantly reduced the number of agents that can be used effectively to treat these infections. Of specific clinical relevance are the slow-growing Mycobacterium avium complex (MAC) ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  8. Development and characterization of HIV-1 Tat degraders

    SBC: Thimble Therapeutics Inc            Topic: NIAID

    AbstractDespite effective antiretroviral therapy (ART), latent proviruses can reinitiate viral production upon cell stimulation or treatment interruption. The viral Tat protein enhances transcript elongation from the HIV-1 promoter, controlling the switch between latency and active viral production. The block-and-lock functional cure aims at the transcriptional silencing of the viral reservoir, re ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  9. Clinical Decision Support System to Optimize Neonatal Nutrition and Growth

    SBC: Medical Predictive Science Corporation            Topic: NICHD

    Project Summary/Abstract: Clinical Decision Support System to Optimize Neonatal Nutrition and Growth Nutrition, defined as energy, macronutrients (protein, fat, and carbohydrates), and micronutrients (e.g., electrolytes), is a critical feature of care for preterm infants in the neonatal intensive unit (NICU). Inadequate nutrition is associated with growth and neurodevelopmental impairment, and inc ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  10. Development and Evaluation of an Integrated Biomarker Capture System for Use in Remote Trials

    SBC: MOUNTAINPASS TECHNOLOGY LLC            Topic: NCATS

    ABSTRACT Remote trials are led and coordinated by a local investigative team, but are based remotely, typically in the participant’s home. Remote trials offer several advantages over traditional in-person trials including: 1) a wider participant pool, 2) reduced regulatory hurdles, and 3) reduced participant burden. Remote trials face one key methodological limitation: the need for biomarker col ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
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