Award Data

DESCRIPTION (provided by applicant): Up to 170 million people worldwide are chronically infected with HCV Hepatitis C virus (HCV) putting the infected individuals at significant risk for cirrhosis, liver failure and liver cancer. End- stage liver diseasecaused by HCV is the leading indication of liver transplantation (LT) in the United States. However, reinfection with HCV occurs universally and ...

In the phase II effort, Intelligent Automation Inc., (IAI) and University of Central Florida (UCF) propose to develop a comprehensive numerical test suite for benchmarking current and future high performance computing activities that will include: (1) dense and unsymmetrical matrix problems faced in space aviation and problems in thermally driven structural response and radiation exchange, (2) imp ...

Filoviruses, consisting of two major virus families including the ebolaviruses and marburgviruses (MARV and RAVV), cause periodic outbreaks of severe viral hemorrhagic fever with mortality rates as high as 90%. Since it is difficult to predict the species that would dominate future outbreaks, development of broadly protective therapeutics to prevent and manage future filovirus outbreaks is of high ...

The objectives of this Phase-II research effort is focused on transitioning noninvasive diagnostic techniques based on ultrafast lasers for characterizing nanoenergetic materials and their performance in rocket engine environments. Through the use of ultrafast laser imaging and spectroscopy, it is possible to isolate and characterize each physical process from initiation through energy release an ...

The objectives of this Phase-II research effort is focused on transitioning noninvasive diagnostic techniques based on ultrafast lasers for characterizing nanoenergetic materials and their performance in rocket engine environments. Through the use of ultrafast laser imaging and spectroscopy, it is possible to isolate and characterize each physical process from initiation through energy release an ...

The Keystone and MSU team propose to build on the successful feasibility demonstration conducted during Phase I to complete the development of solid-state joining of high strength and temperature alloys utilizing the Thermal Stir Welding process. The focus alloy for this project is Haynes 230; the alloy of choice typically utilized in rocket engine nozzel skirts. This class of alloy is difficult t ...

The innovation proposed here is a high-performance, high-fidelity framework in the computational fluid dynamics (CFD) code called Loci-STREAM to enable accurate, fast and robust simulations of unsteady multiphase flows such as combustion involving liquid-gas phases in liquid rocket injectors and solid-gas phases in solid rocket motors, and cryogenic cavitation in delivery systems of liquid rocket ...

DESCRIPTION (provided by applicant): Highly Active Anti-Retroviral Therapy (HAART) used to treat HIV/AIDS has serious side-effects, including metabolic complications from mitochondrial toxicities that can be life-threatening, and limit effectiveness and patient compliance. Adverse metabolic effects are now managed by adept clinicians who monitor patients closely for clinical symptoms and adjust t ...

DESCRIPTION (provided by applicant): In the last decade, Acinetobacter baumannii has emerged as one of the most highly antibiotic-resistant pathogens in the United States (US) and throughout the world. These infections are increasingly prevalent and highlylethal, killing 50-60% of those infected. Worse, strains of A. baumannii that no known antibiotic will kill have now emerged, and will continue ...

DESCRIPTION (provided by applicant): The goal of this project is to synthesize, based on genomic sequence information, a human cytomegalovirus (HCMV) strain with demonstrated ability to establish persistent infection in sero-positive individuals. The resulting synthetic product will form the basis for the development of attenuated HCMV vaccines. Innovative synthetic biology methods will overcome ...