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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 131 - 140 of 207699 results
  1. Engineered Biotherapeutic Agent for Treatment of Post-Traumatic Osteoarthritis

    SBC: Provizigen LLC            Topic: NIAMS

    PROJECT SUMMARY/ABSTRACT Post-traumatic osteoarthritis (PTOA) is a degenerative disease of cartilage brought on by traumatic injury to the articular joints. Acute joint injury is followed by severe joint pain and inflammation. This results in much more rapid degeneration of cartilage than in other forms of osteoarthritis, due to the joint instability caused by trauma as well as the increase in pro ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  2. A Machine Learning Algorithm to Assess Functional "Brain Age" from an In-Home EEG Sleepband

    SBC: NEUROGENECES, INC.            Topic: NIA

    1 PROJECT SUMMARY2 Humans are living longer, resulting in our bodies outliving our brains. Although behavioral changes and better3 management of health conditions can help reverse or slow down premature decline in brain function, pre-4 symptomatic adults are not identified early enough when these changes would make the most significant positive5 impact. Effective intervention requires early detect ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. A new process to improve the mechanical performance of crosslinked UHMWPE injoint replacement prostheses

    SBC: POLYMERIX TECHNOLOGIES LLC            Topic: NIAMS

    While total joint replacement prostheses have been a great success for over 80 years in providing mobility to patients with osteoarthritis, post-surgery complications like aseptic loosening, dislocation and infections remain as problems, often leading to costly and complicated revision surgery. The objective of this proposal is to address implant dislocation, the second most common complication fo ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Pre-Clinical Assessment of a Minimally Invasive Meniscus Implant to Delay Arthritis

    SBC: ORTHOPRESERVE LLC            Topic: NIAMS

    Abstract Meniscus tears are among the most common orthopedic injuries, with about 1 million occurring in the United States each year and growing at a rate of 5% annually. Shortcomings associated with the current standard of care leaves a clinical need for a new treatment option. The meniscal tissue can only be repaired in limited cases due to its healing capacity, so the most common treatment for ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Development of a Piezoelectric Intramedullary Nail for Enhanced Fracture Healing

    SBC: EVOKE MEDICAL LLC            Topic: NIAMS

    PROJECT SUMMARY The objective of this Phase I SBIR is to develop a modular piezoelectric intramedullary nail for enhance fracture healing and post-operative data collection. Evoke Medical’s core technology is to create human- powered implantable devices that utilize piezoelectric materials to generate load-induced power. That power can then be used for various purposes: electrical stimulation of ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  6. Non-invasively extendable megaprosthesis

    SBC: Granite Medical, LLC            Topic: NIAMS

    ABSTRACT This project is the development of a non-invasively extending distal femur replacement (DFR) for children and adolescents subsequent to bone tumor resection. Each year in the US there are 200-250 malignant bone tumor diagnoses in the distal femurs of patients 15 years and younger. With advances in chemotherapy, limb salvage surgery utilizing a megaprosthesis has increasingly become the tr ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  7. Fluoroscopic drill attachment for orthopedic trauma surgery

    SBC: ECLIPSE ORTHOPAEDICS, LLC            Topic: NIAMS

    Abstract For about 175,000 leg and hip fractures each year, the best treatment is for an orthopaedic surgeon to implant a stiff metal rod, or intramedullary (IM) nail, through the center of the bone and fix the nail to the bone with screws (distal locking). Distal locking can be difficult and time-consuming step and presents two major challenges. First, the procedure uses C-arm fluoroscopy for gui ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  8. Ice-free vitrification and nanowarming of meniscal grafts for transplantation

    SBC: TISSUE TESTING TECHNOLOGIES LLC            Topic: NIAMS

    ABSTRACT: Limited availability of fresh viable donor meniscal grafts reduces size-matching efficiency for meniscal allograft transplantation, restricting surgical accessibility and patient outcomes. Current preservation methods with retention of meniscal viability are inadequate. Fibrochondrocyte viability of transplanted menisci is accepted as one of the determinants of outcome following allograf ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  9. A First-in-class Topical Immunoregulatory Therapeutic for Psoriasis

    SBC: Biotherapeutics, Inc.            Topic: NIAMS

    A First-in-class Topical Immunoregulatory Therapeutic for Psoriasis BioTherapeutics Inc (BTI) is an emerging biotech company that synergistically combines the power of advanced computational modeling with translational experimentation to accelerate the development of novel product candidates for precision immunology. An unmet clinical need for safer, more effective drugs for plaque psoriasis remai ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  10. A Telehealth Intervention to Increase Screening and Treatment for Alcohol Use Disorder

    SBC: Ria Technology Management Inc.            Topic: 350

    AbstractRia Health is a nationally scaling early-stage telemedicine and technology company that treats alcohol use disorder with a combination of objective measures of drinking (twice daily breathalyzer measures through our app), physician-supervised medications, and group and individual coaching - the Ria Treatment Platform. Ria has enrolled more than 4,500 patients, is available in 45 states, an ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
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