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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 131 - 140 of 207712 results
  1. Ab-Initio Geometry Optimization of Large Molecules

    SBC: Q-CHEM INC            Topic: N/A

    DESCRIPTION (provided by applicant): Density-Functional Theory (DFT) is highly desirable for modeling biomolecules due to its accuracy. While DFT calculations of the energy are now common for large molecules, the use of DFT geometry optimizers is still confined to relatively small molecules containing no more than thirty atoms. The key limitation is that the number of steps required to reach the o ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  2. Ab-Initio Geometry Optimization of Large Molecules

    SBC: Q-CHEM INC            Topic: N/A

    DESCRIPTION (provided by applicant): While density-functional calculations of the energy are now feasible for biomolecules, the use of density-functional geometry optimizers is still confined to relatively small molecules containing no more than thirty atoms. The key limitation of conventional density-functional geometry optimizers is that the cost of the geometry optimization scales at least qua ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  3. AB INITIO QUANTUM CHEMISTRY ON PARALLEL AND DISTRIBUTED COMPUTERS WITH GAUSSIAN 92

    SBC: Scientific Comput Assoc            Topic: N/A

    THIS RESEARCH EXPLORES THE ISSUES INVOLVED IN PARALLELIZING GAUSSIAN 92, THE MOST WIDELY USED ELECTRONIC STRUCTURE SOFTWARE PACKAGE, USING THE LINDA PROGRAMMING ENVIRONMENT FOR WORKSTATION NETWORKS AND MULTIPROCESSORS. SINCE BOTH GAUSSIAN 92 AND LINDA EMPHASIZE PORTABILITY ACROSS MULTIPLE COMPUTER ARCHITECTURES, THIS PROJECT OFFERS CHEMISTS ELECTRONIC STRUCTURE MODELING WITH THE POWER OF PARALLEL ...

    SBIR Phase II 1994 National Science Foundation
  4. AB INITIO QUANTUM CHEMISTRY ON PARALLEL AND DISTRIBUTED COMPUTERS WITH GAUSSIAN 92

    SBC: Scientific Comput Assoc            Topic: N/A

    N/A

    SBIR Phase I 1993 National Science Foundation
  5. A Bioactive Nanofibrous Sewing Cuff for Treatment of Cardiac Valvular Disease

    SBC: BIOSURFACES INC            Topic: NHLBI

    PROJECT SUMMARY Cardiac valve repair or replacement is indicated when progression of degenerative disease or bacterial infection of the native valve results in valvular dysfunction, thereby impacting cardiac output. Both procedures require the use of a woven or knitted polyester material with an internal reinforcement (Teflon, silicone or metal) to either stabilize the native valve (annuloplasty r ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. A Bioactive Polymer Designed for Cardiac Assist Devices

    SBC: ABIOMED, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The ultimate objective of this proposal is the development of a novel, bioactive polymer for use in ventricular assist devices (VAD), and other long-term blood contacting implantable devices. Although VADs are becoming an important therapeutic option for patients in heart failure, serious problems persist secondary to thromboembolic complications and continue t ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  7. A Bioactive Prosthetic Vascular Graft

    SBC: BIOSURFACES INC            Topic: N/A

    DESCRIPTION (provided by applicant): Over 60,000 prosthetic grafts, which are comprised of either polyethylene terephthalate (polyester) or expanded polytetrafluoroethylene (ePTFE), are implanted in the United States each year. Medium (6-8mm) and small (l t5mm) internal diameter (I.D.) prosthetic arterial grafts continue to have unacceptably high failure rates when used in the clinical setting. T ...

    STTR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  8. A Bioactive Prosthetic Vascular Graft

    SBC: BIOSURFACES INC            Topic: NHLBI

    DESCRIPTION (provided by applicant): Over 60,000 prosthetic grafts, which are primarily comprised of polyethylene terephthalate (polyester) or expanded polytetrafluoroethylene (ePTFE), are implanted in the United States each year. Unfortunately, these grafts continue to have high failure rates due to secondary complications associated with acute thromboses and incomplete, unregulated cellular prol ...

    STTR Phase II 2011 Department of Health and Human ServicesNational Institutes of Health
  9. A Bioactuator-Driven Ankle Dorsiflexor Unit

    SBC: ADA TECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): A significant number of individuals in the U.S. are affected by diseases and injuries that give rise to a troublesome condition called foot drop. Diabetes mellitus, dysvascular diseases, peripheral neuropathies, and other conditions render some individuals unable to lift their foot effectively during their gait cycle, leaving them susceptible to falling or inju ...

    SBIR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  10. A BioAdhesive to Localize and Direct Stem Cells to Treat Damaged Cartilage

    SBC: Forsagen LLC            Topic: NIAMS

    PROJECT SUMMARY Cartilage injuries progressively degenerate if left untreated, leading to the onset of osteoarthritis. Clinical management of partial-thickness cartilage lesions via arthroscopic debridement (removal) and lavage (flushing joint with fluid) relieve pain but fail to repair or protect the tissue against further degeneration. Intraarticular stem cell injections have gained widespread a ...

    SBIR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
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