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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 141 - 150 of 207712 results
  1. A Bio-based Fuel Cell System for Rural Energy Generation

    SBC: Antek            Topic: N/A

    Electricity generation accounts for greater than 50% of total U.S. farm emissions. Renewable energy sources such as wind and solar power are expensive and unreliable. The fuel costs incurred by U.S. farms are offset by supplemental assistance from the government. Particularly attractive are bio-based approaches which use enzymes or entire cells to directly convert renewable compounds into electric ...

    SBIR Phase I 2006 Department of Agriculture
  2. A Biocatalytic Route to Nitrile Reduction

    SBC: QUZYME, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): The recently identified ykvM gene family encodes an enzyme belonging to a unique family of nitrile oxido-reductases that catalyze the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine, a transformation never before observed in biology. Nitrile containing compounds are ubiquitous in the pharmaceutical, agricultural, and chemical industries, wh ...

    SBIR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  3. A biochemical companion diagnostic platform to measure kinase inhibitor pharmacodynamics in leukemia

    SBC: MICROFLUIDIC INNOVATIONS, LLC            Topic: 102

    DESCRIPTION provided by applicant Kinase inhibitors created a new paradigm in chemotherapy and are a major focus of new oncology drug development The Bcr Abl inhibitor imatinib was a breakthrough drug for chronic myelogenous leukemia with overwhelming early results however at least of patients are either intolerant resistant or experience recurrence within years and individual respo ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. A BIODEGRADABLE, INJECTABLE DELIVERY SYSTEM FOR NSAIDS

    SBC: ATRIX LABORATORIES, INC.            Topic: N/A

    IN THIS RESEARCH, NSAIDS WILL BE INDIVIDUALLY INCORPORATED INTO A DELIVERY SYSTEM. THE IN VITRO DELIVERY RATES WILL BEDETERMINED, AND THEN THE SYSTEM OPTIMIZED TO OBTAIN IN VITRO DELIVERY RATES OF 1 TO 12 WEEKS. THE VARIABLES THAT WILL BE EXAMINED TO OPTIMIZE RELEASE ARE POLYMER TYPE AND MOLECULAR WEIGHT, DRUG LOADING, AND BIOCOMPATIBLE PLASTICIZER CONTENT. FIVE NSAIDS WILL BE INDIVIDUALLY EVALUAT ...

    SBIR Phase I 1990 Department of Health and Human Services
  5. A biodegradable ophthalmic drug delivery device

    SBC: Notus Laboratories, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Our long-term research goal is to develop an ophthalmic, nanofiber-based, biodegradable device that will provide extended release of therapeutic agents to the posterior segment of the eye via transscleral and intravitr eal approaches. This platform device will address the major technical problem in the treatment of posterior eye diseases (diabetic retinopathy, ...

    SBIR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  6. A Biodegradable Thin-Film Mulching System for Weed Suppression in Commercial Crop Production

    SBC: Technical Designs Inc.            Topic: N/A

    Weeds reduce the productivity of vegetable crops. Noxious weeds like nutsedge can contaminate a field in one and a half years. To remediate the weed cost, $7,000 to $11,000 for plastic, fumigant and hand weeding is necessary in strawberries. In southern California, 10 to 20 percent of the farmland has a high-density infestation of nutsedge. Methyl bromide applied at high levels is partially effect ...

    SBIR Phase I 2009 Department of Agriculture
  7. A Biodegradable Vascular Coupling Device for End-to-End Anastomosis

    SBC: Microsurgical Innovations Inc            Topic: NHLBI

    Project Summary The objective of this Phase I SBIR proposal is to demonstrate the feasibility of a device designed to connect two small vessels together simply and easily and that would replace the hand suturing technique currently used to connect vessels in microsurgery and macrovascular end to end vascular repair surgeries This completely biodegradable vascular coupling device VCD being devel ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  8. A Biodegradable Vascular Coupling Device for End-to-End Anastomosis

    SBC: Microsurgical Innovations Inc            Topic: NHLBI

    Project Summary The objective of Microsurgical InnovationsMSIin this proposal is to develop a biodegradable vascular coupling deviceVCDwhich would replace the hand suturing technique currently used to connect arteries and veins in microvascular and macrovascular end to end vascular repair surgeriesOur device works for both arteries and veins and can rapidly connect the two vessel ends together in ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  9. A BIODEGRADABLE WOUND TREATMENT

    SBC: ATRIX LABORATORIES, INC.            Topic: N/A

    WE WILL DEVELOP A BIODEGRADABLE WOUND TREATMENT THAT CAN BE AEROSOLIZED DIRECTLY ONTO A WOUND SURFACE. IT WILL FORM A TOUGH, FLEXIBLE FILM THAT WILL SEAL THE WOUND AND PROVIDE FOR PROPER WATER LEVELS AT THE WOUND SURFACE. AN ANTIBIOTIC WILL BE INCORPORATED INTO THE BIODEGRADABLE POLYMER AND WILL BE SLOWLY RELEASED INTO THE WOUND BOTH TO ELIMINATE EXISTING INFECTION AND TO PREVENT LATER INFECTION. ...

    SBIR Phase I 1991 Department of Health and Human Services
  10. A biodevice for implanting insulin-producing cells in a diabetic patient without

    SBC: Converge Biotech, Inc.            Topic: NIDDK

    DESCRIPTION (provided by applicant): A closed loop, glucose sensing, and insulin responsive system could dramatically improve treatment options for insulin dependent diabetics. Current artificial systems, however, lack the ability to provide this precise control. Clinical islet transplantation, the intrahepatic loading of allogeneic islets, shows the potential to provide this intimate control, by ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
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