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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Development of selective calpain-1 inhibitors for chronic pain

    SBC: 1910 GENETICS INC.            Topic: 105

    PROJECT SUMMARY Never in the history of the United States has the unmet medical need to develop novel, non-opioid therapeutics for chronic pain been more urgent than it is today. More than 65 million US adults suffer from chronic pain, resulting in almost $635 billion in annual healthcare costs. Despite their limited efficacy, and potential for addiction, tolerance, and impaired motor performance, ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  2. Fingerprinting Cancer via Multiparameter Extracellular Vesicle Analysis

    SBC: ELECTRONIC BIOSCIENCES, INC.            Topic: 102

    Project Summary Electronic BioSciences (EBS) proposes, in collaboration with Distinguished Professor Henry White at the University of Utah, to develop a nanopore-based extracellular vesicle (EV) characterization system capable of high-resolution, single-vesicle, solution-based characterization, sorting, and isolation. EVs are nanometer-scale, cell-derived vesicles that are produced by nearly all m ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  3. Exhaled breath drug detection using differential mobility spectrometry

    SBC: VOX BIOMEDICAL LLC            Topic: NIDA

    Project Summary We have conducted a pilot study using some of the elements in the present proposal that provide support for the notion that a well selected set of psychomotor/performance tasks can be used to predict driving impairment via a simulated program. Adding these two approaches to the existing STTR project will add significantly to the value of the data focused on developing a breath test ...

    STTR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  4. COVID-19: High Efficiency SARS-CoV-2 Virus Aerosol Sampling and Sensing

    SBC: AEROSOL DEVICES INC            Topic: NIAID

    As the current COVID-19 pandemic has demonstrated, aerosolized pathogens such as SARS-CoV-2 can spread explosively if not quickly detected. Early detection of these airborne pathogens can help control out- breaks, particularly within vulnerable populations in densely populated spaces including assisted living facili- ties, places of worship, military installations, hospitals, and prisons. To date, ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  5. MiGo: wearable sensors that combine actionable data with a behavioral intervention to improve function after stroke

    SBC: FLINT REHABILITATION DEVICES, LLC            Topic: NICHD

    One of the most impenetrable problems challenging full recovery after stroke is the gap between motor capacity that a stroke survivor regains (i.e. what they can do) and how they engage in home and community activities (i.e. what they choose to do). To address this challenge, Flint Rehab developed MiGo, a novel multi-sensor activity tracker specifically designed for stroke survivors. The unique fe ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  6. CCR4-IL2 Bispecific Immunotoxin for Targeted Therapy of Cutaneous T-Cell Lymphoma

    SBC: ROCK IMMUNE LLC            Topic: 102

    Abstract Cutaneous T-cell lymphoma (CTCL) is a type of extra-nodal non-Hodgkin’s lymphoma characterized by skin lesions resulting from infiltration of malignant T lymphocytes. Mycosis fungoides and Sezary syndrome are the two most common types of CTCL. Although treatments exist, they are mainly palliative with low response and durability of response without any cure. The objective response rate ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  7. Allosteric Drug Discovery using Quantum Cascade Laser based Anisotropic THz Microscope (QCL-ATM)

    SBC: LONGWAVE PHOTONICS LLC            Topic: 400

    Allosteric Drug Discovery using Quantum Cascade Laserbased Anisotropic THz Microscope (QCL-ATM) Proposal in Response to NIH/NIGMS STTR PA-20-265 This STTR will result in a commercially viable instrument that will enable critical research in allosteric drugs and protein dynamics. To date allosteric inhibitors are largely found serendipitously. Anisotropic THz microspectroscopy (ATM) uniquely measur ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  8. An Efficacy Trial of a Digital Therapeutic for Suicide Prevention

    SBC: OUI THERAPEUTICS INC            Topic: 104

    ABSTRACT Suicide is one of the top ten causes of death in the US and suicide rates have increased steadily over the last twenty years. Currently, the most effective treatment options are cognitive behavioral therapies for suicide prevention (CBT-SP), which have been shown to reduce both suicide attempt (SA) risk and suicide ideation (SI). However, access to these treatments is limited because ther ...

    STTR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  9. Mindfulness Based Stress Reduction Application for African American Caregivers

    SBC: COG ANALYTICS, LLC            Topic: NIA

    AbstractThere are approximately 43.5 million informal (unpaid) caregivers in the U.S., of which 5.6 million are African American. Informal caregivers often provide a variety of types of support including emotional, physical, and financial, to people with chronic conditions.1 Providing care can be very stressful and emotionally and physically exhausting for informal caregivers.2 African American ca ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  10. Cancer Immunotherapy Targeting Tn Antigen

    SBC: GLYTR THERAPEUTICS, INC.            Topic: 100

    AbstractCancer immunotherapeutic bi-specific proteins and engineered Chimeric Antigen Receptor T cells (CAR T) have shown remarkable clinical activity, with complete response rates as high as ~90% for B cell malignancies. However, applying these two therapeutic approaches to the vast majority of cancer types is restricted by multiple factors. First, there are only a small number of known cell-surf ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
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