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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Multi-modal cloud based system for detecting early signs of driver cognitive decline and/or high risk driving behaviors

    SBC: PHYSICAL SCIENCES INC.            Topic: NIA

    Project Summary/AbstractPhysical Sciences Inc. (PSI), in collaboration with Michigan State University (MSU) and the University of Michigan (U-M), proposes to develop a novel technology that will non-intrusively monitor driver cognitive decline and/or high-risk driving behavior that is especially suited for seniors (aged andgt;65). Contextual physiological biomarkers along with computer vision base ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  2. A two-dimensional antiscatter grid for dental cone beam computed tomography

    SBC: M2 Technologies LLC            Topic: NIDCR

    Project summary Cone beam computed tomography (CBCT) is a commonly used 3D x-ray imaging modality in dental and craniofacial imaging. While CBCT is primarily employed in evaluating bony anatomy in 3D, soft tissues are often poorly visualized in dental CBCT images. Moreover, tissue densities cannot be extracted accurately from CBCT images. The main culprit behind this problem is scattered radiation ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  3. Amelioration of opioid withdrawal-induced anxiety and craving with heterodyned whole body vibration

    SBC: PHOTOPHARMICS, INC.            Topic: NIDA

    PROJECT SUMMARY Opioid use disorder (OUD) is a rising problem in the United States and around the world, with pain and stress being major factors for initial drug seeking and relapse. The mesolimbic dopamine (DA) system originating in the midbrain ventral tegmental area (VTA) and projecting to the nucleus accumbens (NAc) in the striatum is an important nexus for the rewarding properties of opioids ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  4. Xenon gas treatment to modulate microglia in neurodegenerative diseases

    SBC: General Biophysics LLC            Topic: NIA

    Administrative Supplement Application PA-20-272 Xenon gas treatment to modulate microglia in neurodegenerative diseases (R41AG073059) ABSTRACT ABSTRACT FROM ORIGINAL APPLICATION Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder. Emerging evidence shows that homeostatic dysregulation of the brain immune system, especially that orchestrated by microglia, plays a significant ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  5. Allosteric Drug Discovery using Quantum Cascade Laser based Anisotropic THz Microscope (QCL-ATM)

    SBC: LONGWAVE PHOTONICS LLC            Topic: 400

    Allosteric Drug Discovery using Quantum Cascade Laserbased Anisotropic THz Microscope (QCL-ATM) Proposal in Response to NIH/NIGMS STTR PA-20-265 This STTR will result in a commercially viable instrument that will enable critical research in allosteric drugs and protein dynamics. To date allosteric inhibitors are largely found serendipitously. Anisotropic THz microspectroscopy (ATM) uniquely measur ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  6. Development of a ZIKA viral pseudoinfectious virus as ZIKA vaccine candidate (STTR Phase II)

    SBC: Tengen Biomedical Co            Topic: NIAID

    Development of Zika viral pseudoinfectious virus as zika vaccine candidate(Phase 2) Abstract Zika virus epidemics and the association of ZIKV infection with Guillain–Barré syndrome, and congenital disabilities, including microcephaly, led the World Health Organization to declare ZIKV a “Public Health Emergency of International Concern” in 2016. Since then, various ZIKV vaccine platforms hav ...

    STTR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  7. Development of a commercially viable machine learning product to automatically detect rotator cuff muscle pathology

    SBC: SPRINGBOK INC            Topic: NIAMS

    PROJECT SUMMARY Rotator cuff tears are highly problematic for large patient populations, and therefore remain a very challenging clinical problem. Roughly 20% to 50% of those 60 years of age have a known rotator cuff tear and the prevalence only increases with age. While surgical reconstruction of the rotator cuff seeks to improve shoulder function and stability, the degrees of successful surgical ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  8. Combined Cardiomyopathy, e.g., of Cancer Chemotherapeutics, and Proarrhythmia for Cardiotoxicity Clinical Trials-in-a-Dish (CTiD) with iPSC-Derived Cardiomyocytes

    SBC: VALA SCIENCES, INC.            Topic: NHLBI

    Cardiotoxicity is a leading cause of drug discovery attrition across all of preclinical and clinical drug discovery. While the FDA and the Comprehensive in vitro Proarrhythmia Assay initiative (CiPA) are focused primarily on predicting proarrhythmic effects, drug attrition due to cardiomyopathy, or primary cardiac cytotoxicity, may be even more prevalent, is typically currently only carried out vi ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  9. Smart, integrated well-plates for ultra-high-throughput screening of excitation-contraction coupling in tissues

    SBC: FORCYTE BIOTECHNOLOGIES, INC.            Topic: NIGMS

    Project Summary Heart disease remains the leading cause of mortality in the world and, drug-induced cardiotoxicity is a major cause of drug failure and withdrawal from the clinic or the market, contributing to the poor overall success rate of drug development programs. In vitro models of cardiac contractility have the potential to generate predictive data earlier in the pipeline to reduce later-st ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  10. A SARS-CoV-2 Breathalyzer for Direct Virus Detection

    SBC: AEROSOL DEVICES INC            Topic: NIDCR

    Project Summary A substantial and growing body of evidence has demonstrated that COVID-19 is transmitted by human-emitted airborne particles; therefore, it is critical to rapidly screen individuals to determine whether they are at risk of transmitting the disease to others before they enter large venues (e.g., airports, schools) and smaller ones where extended exposure or close proximity is expect ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
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