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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Ultrasensitive PSA Quantitation Using Smartphone to Reduce Prostate Cancer Monitoring Disparities

    SBC: Instanosis, Inc.            Topic: 102

    Project SummaryProstate cancer is a leading cause of cancer mortality in medically underserved men, due to limited access to quality health care resources. Longitudinal monitoring of very low blood prostate specific antigen (PSA) concentrations (tens of pg/mL) is an important tool for clinical surveillance of patients post radical prostatectomy or radical radiotherapy. Such monitoring requires hig ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  2. Clinical Validation of Myoelectric Implant for Intuitive Prosthesis Control

    SBC: RIPPLE LLC            Topic: 106

    Abstract The goal of this translational NIH SBIR program is to evaluate a small, implantable system for recording myoelectric signals from residual muscles of individuals with forearm amputations. The signals will be wirelessly coupled to an external transceiver for controlling a prosthesis. Compared to conventional surface electrodes, this system will provide: • more channels for prosthesis con ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  3. New Transformation Technology for Gene Editing of Human Mitochondrial DNA Associated With Mitochondrial Diseases

    SBC: NAPIGEN INC            Topic: 300

    PROJECT SUMMARY Human mitochondrial DNA (mtDNA) encodes 37 genes in a small genome of 16,569 bp, which accounts for 0.005% of the total human genome size. Despite the small size of this genetic information, mtDNA is indispensable to human cells. As mitochondria are critical for cellular respiration and ATP production, mitochondria are often referred to as “the Powerhouses of the cell”. Because ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  4. Method for the isolation of antibodies with functional activity against cell surface targets

    SBC: ABBRATECH INC.            Topic: NIAID

    “Method for the isolation of antibodies with functional activity against cell surface targets” ABSTRACT We have derived a method for isolating functional mAbs against cell surface receptors that are separately either agonists, antagonists, and partial agonists. We termed the method Directed Ligand Binding (DLB). And in DLB’s first iteration (DLB1) we have successfully used it for peptide- an ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  5. Point of Care Lung CT for Patients with Acute Respiratory Failure

    SBC: Xoran Technologies LLC            Topic: NHLBI

    Abstract Point of Care Lung CT for patients with Acute Respiratory Failure Two million patients develop acute respiratory failure requiring hospitalization in the US each year, with half requiring mechanical ventilation and more than 20% dying before discharge. Identifying underlying pulmonary pathologies in these patients is essential to ensuring they receive the right treatment, but standard che ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  6. Bioinspired Green Glycolipids as Fugitive Dust Mitigation Agents

    SBC: GLYCOSURF, INC.            Topic: R

    Project Summary Ambient air pollution is a leading contributor to global disease burden that increases morbidity and mortality, and it accounted for 4.2 million deaths in 2015. Mineral dusts are a constituent of total atmospheric particulate matter that affect global biogeochemical cycles, pollute water bodies and air masses, and impact global climate. Dust presents physical (i.e., reduced visibil ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  7. Targeting aldose reductase: A Phase IIb/III trial for the novel use of Epalrestat to treat Congenital Disorders of Glycosylation (PMM2-CDG)

    SBC: MAGGIES PEARL LLC            Topic: 200

    SUMMARY Congenital Disorders of Glycosylation (CDG) is a group of over 150 diseases characterized by limited ability to attach glycans to proteins and lipids. The most common form, loss of phosphomannose mutatase-2 activity (PMM2-CDG), is an orphan disease affecting approximately 1500 patients worldwide. CDG typically presents as severe disease in the first few years of life and is lethal in 20% o ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  8. A novel approach to treat non-alcoholic steatohepatitis (NASH)

    SBC: MITOTHERAPEUTIX, LLC            Topic: 300

    Abstract The goal of this SBIR fast-track application is to carry out a number of IND enabling studies on our siRNA drug candidate, which is designed to treat non-alcohol steatohepatitis (NASH). NASH is a form of non-alcohol fatty liver disease (NAFLD) and results from a pathological accumulation of fat in the liver. Approximately 5 million people have been diagnosed with NASH in the US alone. NAS ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  9. Scaling health and bioscience training technology to informal education

    SBC: Discovery Collective, Inc.            Topic: 500

    PROJECT SUMMARY/ABSTRACT Student engagement in hands-on model building, experimental design, and simulation-based exploration has been shown to propel student learning of biological concepts towards increasing complexity. The long-term goal in developing Model It! is to integrate computational models and simulations throughout all K-12 formal and informal science education. The foundation of this ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  10. Nanomaterial Radioisotope Detectors for Intracellular Measurements

    SBC: SCINTILLATION NANOTECHNOLOGIES INC            Topic: 400

    The capability to analyze cellular uptake of physiological and pharmacological compounds with increasing sensitivity and temporal resolution plays a critical role in understanding the underlying molecular pathways involved in human diseases and disorders. Among the most challenging analytes are those present at very low concentrations with high temporal variability, and small molecules lacking moi ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
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