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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Development of Small Molecule Antagonists of PAR-2 for treatment of asthma

    SBC: PARMEDICS, INC            Topic: NHLBI

    ABSTRACT: Current treatments for asthma largely are aimed at reducing exacerbations by directly treating airway inflammation. While successful in a subset of patients, asthma exacerbations remain a significant cause of morbidity and mortality and can result in airway injury, lung function decline and death. Exacerbations in more severe asthmatics are of particular concern, as health care costs and ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  2. Bronchoscopic lung navigation system for accurately excising lung nodules

    SBC: Navigation Sciences, Inc.            Topic: 102

    ABSTRACT The long-term goal of this project is to develop and commercialize a navigation system that can accurately determine margins in real-time during surgery for lung cancer. Surgery is currently the standard of care for early stage lung cancer. A critical challenge is to reliably identify small, early-stage tumors and resect them with sufficient margins (distance between the edge of tumor and ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  3. Engineered Cyclodextrins to Address 7-ketocholesterol-Associated Diseases ofAging

    SBC: UNDERDOG PHARMACEUTICALS, INC.            Topic: NIA

    Project Summary/Abstract Underdog Pharmaceuticals, Inc. (UDP), in collaboration with the SENS Research Foundation (SRF), aims to demonstrate that 7-ketocholesterol (7KC) is elevated in red blood cells (RBCs) in Atherosclerosis and Alzheimer’s disease. 7KC is primarily created by non-enzymatic oxidation of cholesterol. With only a few exceptions, human tissues lack the ability to metabolize or ex ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  4. Smart, integrated well-plates for ultra-high-throughput screening of excitation-contraction coupling in tissues

    SBC: FORCYTE BIOTECHNOLOGIES, INC.            Topic: NIGMS

    Project Summary Heart disease remains the leading cause of mortality in the world and, drug-induced cardiotoxicity is a major cause of drug failure and withdrawal from the clinic or the market, contributing to the poor overall success rate of drug development programs. In vitro models of cardiac contractility have the potential to generate predictive data earlier in the pipeline to reduce later-st ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  5. Polymer use in Preservation of Tissue Perfusion to Address Sepsis

    SBC: PERFUSION MEDICAL LLC            Topic: 300

    Perfusion Medical is commercializing a novel pipeline product called PEG-20k IV Solution. The company believes this may be the first therapeutic to directly treat lethal complications of sepsis, and as such, support new thinking on the basic mechanisms of the disease. Sepsis or septic syndrome leads to a spectrum of illnesses and occurs at a frequency of 1.7 million people in the US each year and ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  6. Development of low-cost, field-ready nanobodies against snake venom

    SBC: Venomyx, Inc.            Topic: 400

    PROJECT SUMMARY Snakebite constitutes one of the largest and most tenacious public health issues on a global scale. Every year, up to 5 million people will suffer snakebite envenomation, causing approximately 125,000 deaths and 400,000 left with permanent physical disability. Nearly 8,000 snakebites occur in the United States each year. The regions most affected are in Asia, Africa, Latin America, ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  7. Development of a protein palmitoylation assay to monitor treatment of CLN1 Batten Disease

    SBC: Circumvent Pharmaceuticals            Topic: NICHD

    SummaryIn the Specific Aims outlined by the following proposal for an NIH SBIR Phase 1 project, we will use a multi-faceted approach to identify key substrates for targeted assay development to monitor therapy in for CLN1 Batten Disease (CLN1). CLN1 is an ultra-rare neurodegenerative disease that affects children with autosomal recessive mutations in the gene for palmitoyl-protein thioesterase 1 ( ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  8. 3D Printed Silicon Nitride Porous PEEK Composite Spinal Cages for Anti-Infection

    SBC: SINTX TECHNOLOGIES, INC.            Topic: 400

    PROJECT SUMMARY—When neck and back pain becomes intractable, spinal fusion is the gold-standard treatment. However, up to 12% of these fusions fail due to infection, resulting in substantial personal and financial costs. In most cases, these infections are associated with the hardware used to stabilize the fusion. Traditionally molded or machined polyether ether ketone (PEEK) cages are widely us ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  9. High-throughput Single Cell Co-assay of Histone Modifications and Transcriptome

    SBC: EPIGENOME TECHNOLOGIES, INC.            Topic: 400

    AbstractEpigenome analysis can help dissect the transcriptional regulatory sequences that control spatiotemporal patterns of gene expression during anima development and disease pathogenesis, but a major challenge to epigenome analysis is the heterogeneity of primary tissues. Conventional epigenome assays that take bulk tissues as input only produce population average signals. To address this majo ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  10. Diamond NMR spectrometer for microfluidic metabolite profiling

    SBC: ODMR Technologies, Inc            Topic: 400

    Project Summary. Nuclear magnetic resonance (NMR) is among the most powerful analytical techniques ever invented, as recognized by 6 Nobel Prizes for methods development alone. Nonetheless, NMR is notoriously plagued by poor sensitivity. State-of-the-art NMR spectrometers feature detection thresholds of ~1 nanomole for µL sample volumes (~100 nanograms). This places NMR sensitivity many orders of ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
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