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SBC: KLEIN BUENDEL, INC. Topic: 102
Physical activity (PA) is a modifiable risk factor for a number of preventable chronic diseases, including cardiovascular disease, strokes, obesity, and diabetes. These conditions constitute health disparities for African American men. Behavioral interventions have proven to be effective in promoting increases in physical activity. While behavior change programs have been shown to assist participa ...STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
SBC: PATHMAKER MOBILITY CORP. Topic: 109
PROJECT SUMMARY / ABSTRACT Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons in the spinal cord and brain. ALS causes muscle weakness and paralysis and eventually death. According to the ALS Association, every 90 minutes there is a new diagnosis of ALS, as well as an associated death. Nearly 5,000 people are diagnosed with ALS each year and a ...STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
SBC: POINT DESIGNS, LLC Topic: NIBIB
Multi-Modal Fingertip Sensors for Prosthetic HandControl and FeedbackPROJECT SUMMARY / ABSTRACT The goal of the proposed project is to develop a robust, multi-modal prosthetic fingertip sensor – the Point Touch – which 1) has a patented multi-modal sensing capability including measurement of proximity, contact, and force and 2) can augment myoelectric control methods using semi-autonomous cont ...STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
SBC: Biopac Systems, Inc. Topic: NIBIB
Abstract Magnetic resonance imaging (MRI) is critically important for pediatric care and the unusable data caused by patient motion has been estimated to cost $1.4B per year in the United States alone. Currently, a radiologist assesses if the images are satisfactory or not, but an MRI technologist does the imaging, and coordination of communication between the two is costly and slow. We propose to ...STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
A Novel Therapeutic that Harnesses Microtubules to Promote Cavernous Nerve Regeneration after Radical ProstatectomySBC: MICROCURES INC Topic: 300
Radical prostatectomy (RP) is a commonly used treatment option for localized prostate cancer, which carries a high risk for development of erectile dysfunction (ED) because of cavernous nerve (CN) injury. Even newer, nerve-sparing, robotic procedures do not convincingly improve erectile function (EF) outcomes after RP. In addition, ED resulting from RP is often refractory to treatment by orally ad ...STTR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
SBC: ODMR Technologies, Inc Topic: 400
Project Summary. Nuclear magnetic resonance (NMR) is among the most powerful analytical techniques ever invented, as recognized by 6 Nobel Prizes for methods development alone. Nonetheless, NMR is notoriously plagued by poor sensitivity. State-of-the-art NMR spectrometers feature detection thresholds of ~1 nanomole for µL sample volumes (~100 nanograms). This places NMR sensitivity many orders of ...STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
SBC: BUTO CORPORATION Topic: NIA
Abstract. Alzheimer’s disease (AD) affects more than 5M Americans today, and is the most common cause of dementia in adults. While current medications slightly delay symptoms, no medications exist to cure or stop disease progression. A current focus at NIA is to identify novel drug targets, that address resilience to AD; also, there is an increasing perspective at NIA that Multi-target therapy m ...STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
Self-Supervised Training in Geospatial Applications with a Robust Hierarchical Vision Transformer (STAR)SBC: UNIVERSITY TECHNICAL SERVICES, INC. Topic: OSD22A001
Satellite Imagery in Geospatial Intelligence (GEOINT), in conjunction with imagery intelligence (IMINT), geospatial information, and other means of gaining intelligence, has greatly improved the potential of the warfighter and decision makers enabling them to gain a more comprehensive perspective, an in-depth understanding, and a cross-functional awareness of the operational environment. The Artif ...STTR Phase I 2022 Department of DefenseNational Geospatial-Intelligence Agency
SBC: Renova Therapeutics, Inc. Topic: NHLBI
ABSTRACT Type-1 Diabetes Mellitus (T1DM) affects 1.25 million patients in US with 40,000 new patients annually. Lifespan is shortened 11-13 years, due to kidney and heart disease. Tight glucose control reduces microvascular complications and adverse cardiovascular events. Insulin therapy is essential for such patients, but has shortcomings: a) only 1 in 3 patients achieve targeted glucose control ...STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
Preclinical testing of a 3D printed external scaffold device to prevent vein graft failure after coronary bypass graft surgerySBC: BIOGRAFT, INC. Topic: NHLBI
Saphenous vein graft (SVG) failure following coronary artery bypass grafting (CABG) is a critical clinical problem, with recent studies revealing that as many as 25% of vein grafts develop stenosis within 12-18 months after surgery, and up to 50% of grafts occlude within 5-10 years. CABG surgery is the gold standard treatment for patients with severe multi-vessel disease, with over 370,000 procedu ...STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health