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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Assessment of mobile application-delivered lighting interventions for reducing circadian disruption in shift workers

    SBC: ARCASCOPE INC.            Topic: NHLBI

    PROJECT SUMMARY Shift workers experience profound circadian disruption, which can have deleterious long term effects on their health and quality of life. Mood, fatigue, and performance can be improved in shift workers by moving the timing of their peak circadian drive to sleep outside the hours they are expected to work. This can be achieved with a targeted lighting intervention, as light is the p ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  2. A novel vaccine against mosquito-borne Zika virus based on mosquito salivary gland protein AgBR1

    SBC: L2 DIAGNOSTICS LLC            Topic: NIAID

    SUMMARY Arboviruses present a constant threat to human and animal health worldwide. They are transmitted by hematophagous arthropods, primarily mosquitoes. One of them, Aedes aegypti, is the primary vector of several widely spread arboviruses such as Zika, dengue and West Nile viruses, and for most of them, human-licensed vaccines do not exist or are suboptimal. These pathogens are transmitted int ...

    STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  3. A rapid test for congenital syphilis screening

    SBC: MelioLabs Inc.            Topic: NICHD

    PROJECT SUMMARY Since 2014, Congenital Syphilis (CS) cases in the United States, caused by the transplacental transmission of the bacterium Treponema pallidum from mother to child, have increased at an alarming rate. Targeted surveillance studies indicate a rise andgt;185% from 2014 to 2018 alone. Women who acquire syphilis within 4 years of pregnancy will transmit the infection to 80% of their fe ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  4. Solving Sepsis: Early Identification and Prompt Management Using Machine Learning

    SBC: Cohere-Med, Inc.            Topic: 300

    Abstract This fast-track STTR application proposes to enhance, validate, and scale Sepsis Watch, a deep learning sepsis detection and management system built using data from the Emergency Department (ED) Duke University Hospital (DUH). The proposal will extend and enhance Sepsis Watch to EDs, general inpatient wards, and intensive care unit (ICU) settings across multiple health systems in the Unit ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  5. Design and Engineering of Biodegradable 3D Nanoprinted Microcarriers for HIV Drug Delivery

    SBC: INFRATRAC INC            Topic: NIAID

    Precise, customizable drug delivery remains a long-term goal, for HIV in particular, as such technologies would allow therapies tailored to a patient’s biological makeup and potentially improve adherence. Extended-release methods address part of the issue, but face limitations. A novel drug delivery system could offer better pediatric dosing, via both oral and new routes of administration. Exist ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  6. Developing Vertebrate-Specific Replication-Defective Dengue Virus as Novel Single-CycleDengue Vaccine Candidate

    SBC: Tengen Biomedical Co            Topic: NIAID

    Developing Vertebrate-Specific Replication-Defective Dengue Virus asa Novel Single-Cycle Dengue Vaccine Candidate Abstract With an estimated minimum of 390 million dengue virus (DENV) infections per year, the DENV epidemic was listed as one of the world's top 10 public health threats by WHO in 2019. At present, there is no specific treatment. A universal vaccine is urgently needed. DENV vaccine de ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  7. Development of a Gectosome Therapy for Cardiovascular Diseases

    SBC: Vesicle Therapeutics Inc.            Topic: NHLBI

    Project Summary Vesicle Therapeutics Inc aims to develop and commercialize a new therapy for homozygous familial hypercholesterolemia (hoFH). A majority of hoFH is caused by mutations in both alleles of the gene encoding the LDL receptor (LDLR). Since the efficacy of both statins and PCSK9 antibody therapies largely depends on functional LDL receptors, patients with hoFH show limited responses to ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  8. CCR5 immunotoxins as components of HIV cure regimens

    SBC: TENDEL THERAPIES INC            Topic: NIAID

    This project will establish proof-of-concept for CCR5 immunotoxins as HIV reservoir-depletion agents for use in cure strategies. HIV cure and remission strategies require elimination or reduction of the HIV reservoir. Approaches to reservoir reduction pursued by other groups include gene editing, i.e., direct removal of integrated provirus; latency reversal and an accompanying “kill” strategy; ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  9. Development of a Bio-tissue Oxygenation Nanophosphor Enabled Sensing (BONES) system for Quantifying Hypoxia in Bone Marrow

    SBC: SIGRAY, INC.            Topic: 400

    Project Summary/Abstract Low oxygen (hypoxic) environments are known to be important for maintaining the small number of adult stem cells in the human body, such as in bone marrow. These conditions are also believed to enable dormant cancer cells to survive and metastasize years or decades after the original tumor has been destroyed and the reason why bone marrow is one of the most common sites of ...

    STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  10. Empowering providers to improve care for disadvantaged patients: design and prototype testing of novel user interface for electronic health records

    SBC: ASP.MD            Topic: 102

    PROJECT SUMMARY There is an emerging digital divide in healthcare between those who care for disadvantaged patients and those who care for less vulnerable populations. In the past decade, electronic health record (EHR) adoption and use has increased but unequally. Providers caring for disadvantaged populations are less likely to have and use advanced EHRs with sophisticated clinical decision suppo ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
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