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SBC: ACADEMIC WEB PAGES, INC Topic: 104
Project Summary/Abstract (30 lines) In the United States, 15 million children and adolescents need psychological services; yet only one-third receive psychological services of any kind. Even fewer receive care that is consistent with evidence-based guidelines for best practices. This gap has widened dramatically with the negative effects of the COVID-19 pandemic on the mental health of children, c ...STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
SBC: EXBAQ LLC Topic: NIAID
PROJECT SUMMARY/ABSTRACT Two million Healthcare Associated Infections (HAIs) occur per year in the US, killing rt90,000 patients and costing ~$50-100 billion (adjusted by CPI to 2020 dollars). HAIs are the 6th leading cause of death in the US, ahead of diabetes and kidney disease. Reducing HAIs is a top priority of the US Department of Health and Human Services1 and experts have called for novel s ...STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
Feelix @ Home: Testing and optimization of a smart stethoscope for home use to monitor changes in lung status of individuals with chronic conditionsSBC: SONAVI LABS INC Topic: NHLBI
Project SummaryThe goal of this project is to further develop an existing smart stethoscope in order to be capable of monitoring pediatric patients at home who suffer from asthma as well as adults with COPD. Lung diseases impose a serious burden on healthcare systems, individuals and governments. The World Health Organization (WHO) found that chronic obstructive pulmonary disease (COPD) and lower ...STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
SBC: EPIGENOME TECHNOLOGIES, INC Topic: 101
AbstractHistone modifications carry rich information of cellular memory and gene regulatory mechanisms. Single cell analysis of histone modification in conjunction with transcriptome could recover this critical layer of cell identity and help to dissect the cellular and molecular composition of complex tissues such as the brain. We recently developed an ultra-high throughput single cell multi-omic ...STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
SBC: MS Technologies Corporation Topic: NIDCR
Dental CBCT is a 3D imaging modality widely adopted to help dentists detect and diagnose jaw lesions. Due to minimum information loss (compared to conventional 2D radiography) and low radiation exposure (compared to conventional CT), it has become the “go-to” radiographic technique in various dental fields. Gaps: Accompanying the clear benefits of dental CBCT is an overwhelming amount of 3D da ...STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
SBC: ARGOSMD, INC. Topic: 102
Project Summary/Abstract The current standard of care for skin cancer diagnosis, biopsy, is invasive, slow, and burdensome in cost. Skin cancer is the most commonly diagnosed cancer in the US. Biopsy of suspicious skin lesion is the key step of skin cancer diagnosis. 15-20 million skin biopsies are performed in the US annually. Once biopsied tissue is removed from a patient, the biopsy specimen is ...STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
Biomarker-enhanced Artificial Intelligence-Based Pediatric Sepsis Screening Tool Towards Early Recognition and Personalized TherapeuticsSBC: COMPUTER TECHNOLOGY ASSOCIATES, INC. Topic: NIAID
PROJECT SUMMARY The overall objective of this proposed STTR effort is focused on the derivation and validation of a commercialized biomarker-enhanced artificial intelligence (AI)-based pediatric sepsis screening tool (PSCT) that can be incorporated into emergency department (ED) workflows to enhance early recognition and the initiation of timely, aggressive personalized sepsis therapy. The early r ...STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
SBC: Quercus Molecular Design, LLC Topic: NIAID
Abstract: Non-Tuberculosis Mycobacteria (NTM) are responsible for widespread, life threatening infections of the lungs, skin, lymphatic and hematological systems. The rapid, global spread of resistant organisms has significantly reduced the number of agents that can be used effectively to treat these infections. Of specific clinical relevance are the slow-growing Mycobacterium avium complex (MAC) ...STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
SBC: MODALITY.AI , INC Topic: NIDCD
PROJECT SUMMARYAmyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease resulting in the progressive loss of limb, trunk, and head and neck (bulbar) motor function and is the most common adult-onset motor neuron disease. The disease is characterized by significant across-patient heterogeneity in the onset region and in pattern and progression rate, making early and accurate diagnos ...STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
SBC: MICROBIOTIX, INC. Topic: NIAID
Abstract Segmented negative-sense, single-stranded RNA viruses (sNSVs), which include bunyaviruses, are causative agents of human diseases. Rift Valley Fever Virus (RVFV), a bunyavirus, causes hemorrhagic fever in humans with a case fatality rate of patients developing hemorrhagic fever reaching approximately 50% and has been classified by the NIAID as a Category A Priority Pathogen. RVFV is mosqu ...STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health