Award Data

DESCRIPTION (provided by applicant): The treatment of pain in Sickle Cell Disease (SCD) is challenging for both patients and providers and is associated with significant disparities in healt care delivery. While the role of ongoing inflammation during vasooclusive crisis and pain is recognized, effective therapeutic interventions are lacking. Glucocorticoids, with their anti-inflammatory propertie ...

DESCRIPTION (provided by applicant): The overarching goal of this proposal is to evaluate a novel method to mobilize and procure a hematopoietic stem cell (HSC) allograft which we hypothesize will lead to rapid hematopoietic engraftment but cause less graft versus host disease (GVHD) compared to G-CSF mobilized peripheral blood stem cells (G-PBSC) following allogeneic HSC transplantation (HSCT). W ...

N/A

DESCRIPTION (provided by applicant): Functional MRI, diffusion MRI and MR spectroscopy and spectroscopic imaging have great potential for the study and diagnosis of disease and injury, and guiding surgical therapy. All of these methods benefit greatly fro m the added sensitivity, resolution and contrast from high field strength magnets (3T and above). However, the advantages of higher magnetic fi ...

DESCRIPTION (provided by applicant): Multiple studies in MR provide irrefutable evidence that the use of high order shims for controlling magnetic field inhomogeneity brings significant improvement to image quality, particularly at high fields and in challenging shimming regions, such as in the inferior frontal and temporal lobes of the human head. MRI manufacturers however, have been very resista ...

DESCRIPTION (provided by applicant): Functional MRI, diffusion MRI and MR spectroscopy and spectroscopic imaging have great potential for the study and diagnosis of disease and injury, and guiding surgical therapy. All of these methods benefit greatly fromthe added sensitivity, resolution and contrast from high field strength magnets (3T and above). However, the advantages of higher magnetic field ...

DESCRIPTION (provided by applicant): The objective of this phase I STTR application is to continue assessment of the relevance and feasibility of Nogo decoy receptor therapy for the treatment of glaucoma. The secondary objective is to obtain pharmacokinetic data important for designing additional preclinical efficacy studies and formulating a drug development plan for glaucoma. Our long term objec ...

DESCRIPTION (PROVIDED BY APPLICANT): The overall objective of this Fast-Track proposal is to develop and evaluate a novel, neuroscience-based multimedia training program for the treatment of cognitive deficits in schizophrenia. Neurocognitive deficits are a core feature of schizophrenia, and inhibit schizophrenics' ability to participate in rehabilitation programs, maintain social relationships, g ...

Not avaiable.

DESCRIPTION (provided by applicant): Alcohol use disorders are common among primary care patients. They are also associated with serious adverse effects. Many health care professionals, however, often lack sufficient background in alcohol screening and brief intervention strategies to effectively help patients who use alcohol above recommended limits. In particular, they often lack the necessary i ...