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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Developing generalized engineering tools to create enhanced phage therapy for the clinic and commercialization

    SBC: FELIX BIOTECHNOLOGY INC            Topic: NIAID

    ABSTRACT Antibiotic-resistant infections are a major public health threat in the U.S. and globally, with Pseudomonas aeruginosa (Pa) being one of the top pathogens of concern. Phage therapy is a promising approach to treat these infections, with benefits of species-targeted activity that spares the host microbiome, an ability to penetrate biofilms and kill metabolically-inactive persister cells, a ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  2. Highly-sensitive, rapid and low cost plasmonic assay platform for Lyme disease diagnosis

    SBC: CIENCIA INC            Topic: NIAID

    Project Summary/Abstract Lyme disease (LD) is the most common vector-borne illness in the United States and represents a considerable diagnostic challenge. 1-3 The current benchmark for LD diagnosis is the standard two-tiered test (STTT), although the modified two-tier test (MTTT) is rapidly becoming an acceptable alternative. 6 These assays are highly specific but have poor sensitivity, especiall ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  3. Shim System for Removing ICD Artifacts from Patient Cardiac MR Images

    SBC: MIRTECH INC.            Topic: NHLBI

    Project Abstract1.4 million people in the US (2021) have implanted cardioverter-defibrillators (ICDs) of which ~50% will require an MRI scan in their lifetime. All ICDs generate large artifacts in MRI such as signal-voids in cardiac MR (cMR) images, which frequently occur in important pathological (infarcted) regions. Reliable diagnosis of ventricular tachycardia, premature ventricular contraction ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  4. An Interactive Education Program to Reduce High Risk Behavior in Adolescents

    SBC: KLEIN BUENDEL, INC.            Topic: NICHD

    Internet-based TRAC (i-TRAC): Interactive Emotion Regulation Skills Training to Improve AdolescentSexual Health Adolescence is a critical developmental period during which behavioral patterns are formed that have powerful influences on current and future health. This is particularly true for sexual behavior, which is affected by the biological changes of puberty as well as normative developmental ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  5. Targeting cadherin-11 in pancreatic cancer

    SBC: Diviner Therapeutics LLC            Topic: 102

    Pancreatic cancer is soon to be the second leading cause of cancer-related death with an overall median survival of 8 - 11 months. For 70% of patients, systemic chemotherapy is the only option and this mainly relieves the symptoms and/or slightly extends survival, rather than cures the patients. One of the hallmarks of PDAC is extensive fibrosis that comprises up to 80% of the tumor. Cancer-associ ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  6. A novel clot containing system for improved neurothrombectomy outcomes

    SBC: XTRACT MEDICAL INC            Topic: 106

    PROJECT SUMMARY Mechanical thrombectomy (MT) has recently gained impetus as a treatment for acute ischemic stroke (AIS). Although technical progress has been made, the efficacy of the current techniques remains sub-optimal and MT is still associated with significant complications. Current MT techniques, using stent retrievers or aspiration catheters, achieve successful revascularization after the ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  7. A universal droplet microfluidic platform for ultrahigh-throughput biocatalyst evolution

    SBC: Fluid Discovery Inc            Topic: 400

    Abstract The advance of biotechnology is dependent on approaches for rapidly iterating through genetically engineered enzymes and pathways. While computational and gene synthesis techniques have seen considerable innovation in the last few decades, screening variants for desired activities has lagged behind, with few notable advances. Indeed, microwell plates, a nearly 60-year-old technology, rema ...

    STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  8. Continuous Photoacoustic Monitoring of Neonatal Stroke in Intensive Care Unit

    SBC: BRIMROSE TECHNOLOGY CORP            Topic: NIBIB

    PROJECT SUMMARY/ABSTRACT Neonatal encephalopathy can arise from fetal hypoxia-ischemia during labor, chronic uteroplacental inflammation, and large cerebral artery embolization primarily arising from dislodgement of a placental thrombus. Because of overlapping clinical presentation, differential diagnosis is often delayed until seizures develop and MRI can be safely performed, a time at which most ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  9. AI-Based Identification of Rapid Glaucoma Progression to Guide Clinical Management and Accelerate Clinical Trials

    SBC: AISIGHT HEALTH INC            Topic: 100

    Project Summary Glaucoma is the leading cause of irreversible blindness worldwide and is expected to affect more than 110 million people worldwide within the next two decades. It is a degenerative disease that has a large impact both in terms of patient quality of life and in costs to the healthcare system. A critical need in glaucoma clinical management and research is the ability to accurately i ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  10. A Normal Paradigm to Monitor Perinatal Asphyxia Using A Combined Ultrasound-Neuromodulation and Photoacoustic-Imaging Device

    SBC: BRIMROSE TECHNOLOGY CORP            Topic: NIBIB

    PROJECT SUMMARYThe Brimrose Technology Corporation and partner, The Johns Hopkins University, propose using non-invasive ultrasound neuromodulation to identify hypoxic-ischemic encephalopathy (HIE) in newborns to reduce death and lifelong brain injury. HIE is the leading cause of neonatal death and impacts 2-6 of every 1,000 live births in the developed world. Our goal is to investigate and demons ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
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