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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. A New Anti-inflammatory Therapy for Ischemic Stroke

    SBC: CORNOVUS PHARMACEUTICALS INC.            Topic: NHLBI

    PROJECT SUMMARY Current therapy for ischemic stroke is limited and new treatment is needed since the mortality and morbidity of subjects with this condition remain high. Effort aimed at blocking immune cell- mediated inflammation represents a novel approach. The specific background for the proposed project is that we have identified the myeloid P2X4 receptor (P2X4R), which induces inflammation, as ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  2. Epigenetic Markers and Sustained Cytoprotection for Stroke Treatment

    SBC: ZYMO RESEARCH CORP.            Topic: NINDS

    PROJECT SUMMARY/ABSTRACT Stroke injury occurs over a long duration through pathologic changes leading to long-term neurologic dysfunction. There is an urgent need of therapeutic strategies that can provide safe and efficacious therapeutic effects to the hypoperfused brain with long-lasting endogenous neuroprotection for prevention of long-term neurologic dysfunction. Sufficient evidence has pointe ...

    STTR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  3. A Transparent Surgical Mask to Improve Patient/Caregiver Communication, Minimize Errors and Increase Patient Satisfaction

    SBC: FaceView Mask, LLC            Topic: NINR

    PROJECT SUMMARY Approximately 4% of people in the US are either deaf or hard of hearing, equating to more than 13 million people. Of these, approximately 12 million people over the age of 5 years have difficulty hearing normal conversation even when using a hearing aid. Hearing difficulties affect all age groups and present significant challenges in daily life. These challenges are particularly ac ...

    STTR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  4. Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD

    SBC: Aromha Inc            Topic: NIA

    Project Summary / Abstract Over 5.8 million Americans are currently affected by Alzheimerandapos;s disease (AD) with an economic burden estimated at andgt; $270 billion/year in 2020 that is projected to increase at least four fold over the next several decades. Accurate biomarkers have been developed that demonstrate that AD pathology is present 15 years of more prior to the onset of memory sympto ...

    STTR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  5. Automated Mental Health Referral System

    SBC: MiResource, Inc.            Topic: 104

    This proposal addresses a significant barrier to obtaining treatment for college-ageyouth with mental disorders. Many college-age youth with impairing mental disordersremain untreated because of concerns about stigma and privacy, inconvenience and wait times, andbecause universities are often unable to service all such students. Also, of critical importance,when referral for treatment is implement ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  6. Multiplexed CRISPR-based immune cell RNA profiling by flow and mass cytometry

    SBC: DAHLIA BIOSCIENCES, INC.            Topic: NIAID

    Project Summary/Abstract Immune cell profiling is crucial towards understanding key changes in host immune cell subpopulations and functions underlying SARS-CoV-2 viral clearance and immune-mediated pathology. This data will be essential towards the urgent development of COVID-19 diagnostics, therapeutics, and vaccines. Recent publications have showcased the power of scRNA-Seq immune cell profilin ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  7. Biomimetic size-adaptable heart valve for prosthesis-patient mismatch

    SBC: Autus Valve Technologies, Inc.            Topic: NHLBI

    ABSTRACT The overall goal of this Phase I STTR project is to develop a biomimetic size-adjustable prosthetic heart valve (Autus Size-Adaptable Valve) that can be expanded post-implantation to accommodate changes in blood flow due to somatic growth or cardiac remodelling, to prevent the complications of valve prosthesis-patient mismatch (PPM). By design, all existing surgical prosthetic valves have ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  8. Mitigation of Ionizing Irradiation-Induced Intestinal Damage by Second-Generation Probiotics LR-IL-22 and LR-IFN-β

    SBC: CHROMOLOGIC LLC            Topic: R

    Abstract We have developed genetically modified second-generation probiotics for the localized delivery of known mitigators to the GI tract in order to reduce damage and regenerate tissue after exposure to ionizing radiation. Mitigating the effects of ionizing radiation exposure is critical for improving survival in the event of a radiological or nuclear (RAD-NUC) incident, where exposure could le ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  9. Developing a novel drug for neurobehavioral deficits in FASD

    SBC: COGTHERA LLC            Topic: 230

    Project Summary Fetal Alcohol Spectrum Disorder (FASD) is a debilitating condition causing a wide range of disabilities including behavioral and intellectual deficits, facial dysmorphology, and organ malformations. This disorder has a profound impact on health care burden and cost; as many as 5% of children within the United States are affected by this condition, with lifetime treatment costs reac ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  10. X-ray Visualized Interbody Spacer Indicating Biomechanical Load (X-VISIBL) Fusion Device

    SBC: Spinefrontier, Inc.            Topic: NIAMS

    AbstractSpine disorders, primarily caused by degenerative spine conditions, deformity, tumors, and trauma, affect approximately half of the population aged over 40. To address these disorders, over 457,000 spine fusions were performed in the US in 2011 (6% annual growth), including about 290,000 anterior cervical discectomy and fusions (ACDF). ACDF surgery removes 1-4 intervertebral discs and repl ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
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