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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Attenuation of Radiation-Induced GI Injury by Cultured Myeloid Progenitors

    SBC: Cellerant Therapeutics, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Our long term goal is to develop a universal cell-based therapy containing human myeloid progenitor cells to attenuate radiation-induced gastrointestinal or hematopoietic injury. Radiation (XRT) remains an important therapeutic modality in the treatment of malignancies. Injury to the gastrointestinal tract (GI) and hematopoietic system are serious sequelae of r ...

    STTR Phase I 2007 Department of Health and Human ServicesNational Institutes of Health
  2. SAMPLE PROCESSING CARTRIDGES FOR RAPID PCR TB DETECTION

    SBC: CEPHEID            Topic: N/A

    DESCRIPTION (provided by applicant): Conventional methods to identify and test the antibiotic susceptibility of Mycobacterium tuberculosis are both slow and insensitive. Current nucleic acid amplification-based techniques present a partial solution by offering a more rapid result, but these methods require a relatively high degree of technical sophistication. Furthermore, assay sensitivity is oft ...

    STTR Phase I 2002 Department of Health and Human ServicesNational Institutes of Health
  3. Sample Processing Cartridges for Rapid PCR TB Detection

    SBC: CEPHEID            Topic: N/A

    DESCRIPTION (provided by applicant): Cepheid Inc and the New Jersey Medical School have developed an assay system that integrates sample processing and real-time PCR diagnosis into a single, hands free process. During the successful completion of a phase I STTR application we demonstrated that this system simultaneously detect the presence of Mycobacterium tuberculosis (TB) and diagnose rifampin r ...

    STTR Phase II 2006 Department of Health and Human ServicesNational Institutes of Health
  4. Automated RNA Isolation and RT-PCR for Cancer Detection

    SBC: CEPHEID            Topic: N/A

    DESCRIPTION (provided by applicant): Cepheid develops integrated sample preparation and detection systems for rapid molecular diagnostic applications at a point of use environment. Currently, Cepheid has the GeneXpert system, which is a cartridge and instrument platform for integrated sample preparation and real-time PCR detection of target nucleic acids in biological samples. The current config ...

    STTR Phase II 2004 Department of Health and Human ServicesNational Institutes of Health
  5. Automated RNA Isolation and RT-PCR for Cancer Detection

    SBC: CEPHEID            Topic: N/A

    DESCRIPTION (provided by applicant): Cepheid develops integrated sample preparation and detection systems for rapid molecular diagnostic applications at a point of use environment. Currently, Cepheid has the GeneXpert system, which is a cartridge and instrument platform for integrated sample preparation and real-time PCR detection of target nucleic acids in biological samples. The current config ...

    STTR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  6. Protection from hearing loss using calpain inhibitors

    SBC: CEPTOR CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): In recent years, progress towards elucidating the molecular and cellular basis of neurodegeneration has accelerated due to our greater understanding of the role of proteases in degenerative conditions. In particular, the combined effect of increased intracellular Ca ++coupled to activation of calpains, intracellular proteases, in disorders such as stroke, ALS, ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  7. Vaccine-enhanced DLI to prevent cancer recurrence after stem cell transplantation

    SBC: CERUS CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): Delayed reconstitution of antigen-specific immunity following allogeneic hematopoietic stem cell transplantation (HSCT) predisposes patients to opportunistic infections and tumor recurrence. To address these problems, we are developing a vaccination methodology using a non-replicating but highly immunogenic Listeria monocytogenes (Lm) vector. When an Lm vaccine ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  8. DRUG DISCOVERY FOR TREATMENT OF OBESITY

    SBC: Chemdiv, Inc.            Topic: N/A

    The goal of this research project is to define the structure and radioactive label for ligands that will permit quantitative measurement of serotonin transporter (5-HTT) sites in living brain by external imaging with positron or single-photon emission tomography (PET or SPECT). The serotonin transporter is known to play a role in several physiological and pathophysiological processes, especially i ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  9. Identification of Novel ACTH small molecule Antagonists

    SBC: Chemdiv, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The production of adrenal gland hormones, including cortisol and androgens, is regulated by pituitary ACTH (adrenocorticotropin hormone), which acts via the melanocortin-2 receptor (MC2R) to stimulate steroid production. The ability to antagonize ACTH action would greatly facilitate the care of several clinical conditions, including congenital adrenal hyperplas ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  10. Identification of Novel ACTH Small Molecule Antagonists

    SBC: Chemdiv, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Development of drugs based on the MC2R antagonists will directly benefit children with CAH and Cushing's diseases, and will help us to understand MC2R's role in metabolic pathways. The long term goal of this project is to discover small molecule inhibitors of MC2 receptor and develop drug to treat several metabolic diseases including CAH and Cushing's diseases ...

    STTR Phase II 2006 Department of Health and Human ServicesNational Institutes of Health
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