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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Network Pharmacology for Epilepsy Prevention

    SBC: PREVEP, LLC            Topic: 106

    ABSTRACT Prevention of epilepsy is a major unmet need in neurology. Approximately 20% of all epilepsy is due to acute brain insult such as traumatic brain injury (TBI, 5%), stroke (10%), and CNS infection (~5%).Following these injuries, there is a latency of days to years before epilepsy develops. This offers opportunity to intervene with treatment to prevent or modify epilepsy. No such treatment ...

    SBIR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  2. Technologies for OUD Prevention, Control and Supportive Care- Development of Patient/Caregiver mobile application and Provider Dashboard

    SBC: AIDAR HEALTH INC            Topic: NIDA

    ABSTRACT Pain is an important issue for both society and health care. The increasing frequency of individuals with chronic pain as the result of chronic diseases and postoperative pain have directly led, over the past two decades, to the over-prescription and misuse of opioids. In early 2019, an estimated 130 people per day were dying from opioid- related drug overdoses, 2 million people were misu ...

    SBIR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  3. A Novel RNA Therapeutics Platform to Treat Facioscapulohumeral Muscular Dystrophyand other Neuromuscular Disorders

    SBC: MIRECULE INC            Topic: 106

    Abstract: In this Fast Track SBIR application miRecule proposes to develop a muscle-specific platform (Muscle-NAVTM) for the delivery of therapeutic oligonucleotide to treat inherited neuromuscular disorders. Over 50 inherited neuromuscular disorders including myopathies, muscular dystrophies, and metabolic muscle disorders have been identified with a monogenic underpinning, resulting from mutatio ...

    SBIR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  4. Validation of the online Toddler Autism and Development Adaptive Screener (TADAS) at 18 months

    SBC: CHADIS, INC.            Topic: NICHD

    Project Summary Abstract The American Academy of Pediatrics has mandated identification of autism (ASD) beginning at the routine 18-month visit, based on evidence that early intervention for children with autism improves outcomes. However, the US Preventive Task Force has not endorsed that recommendation, in part because of limited validity data. This study builds on a series of studies by our gro ...

    SBIR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  5. Discovery of Small Molecules as Antimalarial Agents

    SBC: CASCADE THERAPEUTICS, INC.            Topic: NIAID

    PROJECT SUMMARYThe proposed research focuses on the development of novel therapeutic agents for the treatment of malaria caused by P. falciparum. Preliminary studies have discovered novel natural product and derivative molecules with potent in vitro activity against both sensitive and multidrug resistant malaria strains including a newly emerging artemisinin resistant parasite line. New compounds ...

    SBIR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  6. I-Corps: Optical design and the development of high accuracy automated tick classification using computer vision

    SBC: VECTECH, INC.            Topic: NIAID

    Abstract The incidence of US tick-borne diseases has more than doubled in the last two decades. Due to lack of effective vaccines for tick-borne diseases, prevention of tick bites remains the primary focus of disease mitigation. Tick vector surveillance - monitoring an area to understand tick species composition, abundance, and spatial distribution - is key to providing the public with accurate an ...

    SBIR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  7. System for the Large-scale Production of Membrane Proteins

    SBC: Athena Environmental Sciences Inc            Topic: 400

    Membrane proteins play a fundamental and critical role in cellular processes. Their direct link to human disease as well as their key role in signal transduction, has made many membrane proteins the foremost targets for chemotherapeutic intervention with more than 50% of all drugs designed to modulate the activity of this class of proteins. Despite this central role in human health, the biochemica ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  8. Development of a Universal Immunotherapeutic for Influenza Viruses

    SBC: Integrated Biotherapeutics, Inc.            Topic: NIAID

    Project Summary Influenza virus (INFV) results in global seasonal and pandemic outbreaks estimated to cause severe illness in 3 to 5 million people annually resulting in significant morbidity and up to 650,000 deaths. The influenza burden also results in substantial economic loss. The goal of this program is to develop a therapeutic antibody offering effective treatment with broad heterosubtypic s ...

    SBIR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  9. Low Cost Carbon Dioxide-Based Cryoablation for Breast Cancer Treatment in Low Resource Settings

    SBC: KUBANDA CRYOTHERAPY            Topic: 102

    Summary The principal goal of this proposal is to demonstrate equivalence in efficacy of CO2- based percutaneous cryotherapy compared to commercial argon-based devices in order to improve the accessibility of a novel low-cost breast cancer treatment device for women in low-resource areas. Breast cancer is the leading cause of cancer death among women worldwide. Though more than 800,000 women are d ...

    SBIR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  10. Development of a Novel Chemokine Receptor Antagonist Peptide as a Non-Opioid Treatment for Relief of Chronic Pain

    SBC: CREATIVE BIO-PEPTIDES INC            Topic: 106

    7. Project Summary In response to RFS-NS-20-11, Creative Bio-Peptides, Inc. will develop the multi-chemokine receptor antagonist peptide R103 to provide a non-opioid, potentially disease modifying treatment for neuropathic pain conditions. We have completed proof-of-concept (POC) animal studies in neuropathic pain by partial nerve ligation and diabetes. We will conduct a further POC study of R103 ...

    SBIR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
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