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Clinical validation and commercialization of a novel hydrogel-based vaginal packing system for pelvic brachytherapySBC: BrachyFoam, LLC Topic: 102
This proposal aims to complete preclinical validation and commercialize a novel vaginal packing product based upon a biocompatible polymer hydrogel strategy. The hydrogel will form in situ after being injected into a bag placed within the vaginal cavity during pelvic brachytherapy. The hydrogel packing can then be removed readily after the brachytherapy treatment. This Phase II proposal focuses on ...STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
Production and Characterization of Human Immunoglobulin Producing Goats for Diagnostic Reagents and TherapeuticsSBC: SAB CAPRA, LLC Topic: NIAID
Project Summary/Abstract The ultimate goal of this phase II STTR proposal is to expand the capabilities of SABandapos;s diversitAb™ platform by continuing advanced development of Transchromosomic goats (TcGs). This will be accomplished by producing male and female goat endogenous immunoglobulin gene knockout cell lines that contain SAB Capraandapos;s human artificial chromosome (HAC) which encod ...STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: AMELIA TECHNOLOGIES LLC Topic: NIEHS
Project SummaryThe objective of this supplementation request is to further our recent advances in the development of thewell Immuno CometChip assay results and build a prototypewell preformer giving the assay more utility and increasing commercial viabilitySTTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: Eigen Health Services LLC Topic: 102
Project Summary Prostate cancer is one of the most commonly occurring forms of cancer, accounting for 21% of all cancer in men. The Prostate Imaging Reporting and Data System (PI-RADS) aims to standardize reporting of prostate cancer using multi-parametric magnetic resonance imaging (mpMRI). However, the in-depth analysis, as demanded by PI-RADS, remains challenging due to the complexity and heter ...STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
Enabling self-reported outcomes for youth with developmental disabilities: The PediatricEvaluation of Disability Inventory- Patient Reported Outcome (PEDI-PRO)- Phase IISBC: ABLELINK TECHNOLOGIES INC Topic: NICHD
The lack of patient reported outcome measures (PROMs) appropriate for youth with neurodevelopmental disabilities (DD) and related cognitive impairments including Down syndrome (DS) poses a significant problem for healthcare research and practice. Parents and other professionals do not identify the same needs as youth, and failure to engage youth with DD in healthcare evaluation compromises healthc ...STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
SBC: NeoVative, Inc. Topic: 400
“Code blue” is the signal used in hospitals to call for an immediate cardiopulmonary resuscitation (CPR) following a cardiac or respiratory arrest. Reviewing the performance of the “code blue team” is a cornerstone for improving outcomes. The current standard of using handwritten records on a paper “code sheet” does not allow measurement of key quality indicators and is subject to huma ...STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: KLEIN BUENDEL, INC. Topic: 102
Physical activity (PA) is a modifiable risk factor for a number of preventable chronic diseases, including cardiovascular disease, strokes, obesity, and diabetes. These conditions constitute health disparities for African American men. Behavioral interventions have proven to be effective in promoting increases in physical activity. While behavior change programs have been shown to assist participa ...STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
SBC: Proactive Memory Services Topic: NIA
DESCRIPTION provided by applicant THE MEMORY CARE NAVIGATOR A PROACTIVE GUIDE Memory loss is an increasing problem as our population ages causing a tremendous personal and societal toll in disability and cost Alzheimerandapos s disease AD the most common cause of dementia is the illness elderly Americans most fear and the only major illness with an increasing mortality rate Despite subs ...STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: TECHLAB, INC. Topic: N/A
DESCRIPTION (provided by applicant): Our specific objective with this fast-track STTR application is a diagnostic screen for the NIAID Biodefense Category B intestinal pathogens Giardia lamblia, Cryptosporidium spp., and Entamoeba histolytica in stool. The se enteric protozoa share the characteristics of food and water-borne transmission, low infectious dose, and environmental stability. E. histol ...STTR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
SBC: Renova Therapeutics, Inc. Topic: NHLBI
ABSTRACT Type-1 Diabetes Mellitus (T1DM) affects 1.25 million patients in US with 40,000 new patients annually. Lifespan is shortened 11-13 years, due to kidney and heart disease. Tight glucose control reduces microvascular complications and adverse cardiovascular events. Insulin therapy is essential for such patients, but has shortcomings: a) only 1 in 3 patients achieve targeted glucose control ...STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health