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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

Displaying 163631 - 163640 of 169241 results
  1. A LITERATURE REVIEW OF FUNGALLY DERIVED ANTITUMOR AGENTS REVEALS THAT THE FUNGI CONSTITUTE A GROUP OF EASILY COLLECTED SPECIES INDIGENOUS TO WESTERN EUROPE, THE EASTERN UNITED STATES, AND JAPAN.

    SBC: Mycosearch Inc            Topic: n/a

    A LITERATURE REVIEW OF FUNGALLY DERIVED ANTITUMOR AGENTS REVEALS THAT THE FUNGI CONSTITUTE A GROUP OF EASILY COLLECTED SPECIES INDIGENOUS TO WESTERN EUROPE, THE EASTERN UNITED STATES, AND JAPAN. THEIR AVAILABILITY MAY HAVE BEEN THE DECISIVE FACTOR IN THESE DRUG DISCOVERIES. SIGNIFICANTLY, THEIR HABITAT RANGES ARE BROAD AND SUGGEST THAT OTHER SAPROPHYTIC AND PARASITIC FUNGI, WORLDWIDE, MAY HAVE DEV ...

    SBIR Phase I 1986 Department of Health and Human Services
  2. ANTITUMOR AGENTS FROM NATURAL SOURCES

    SBC: Naprotech Inc            Topic: n/a

    PLANTS AND OTHER LIVING ORGANISMS REPRESENT VALUABLE STARTING MATERIALS FOR THE ISOLATION OF CLINICALLY EFFICACIOUS ANTICANCER AGENTS. THE MECHANISM OF ACTION OF NEARLY ALL ANTICANCER AGENTS INVOLVES DISRUPTING THE NORMAL PHYSIOLOGICAL FUNCTION OF DNA, AND MANY AGENTS ACT BY DIRECTINTERACTION. THUS, BY UTILIZING THIS KNOWN TARGET MACRO- MOLECULE, NAPROTECH CURRENTLY PROPOSES TO DEVISE METHODS FORT ...

    SBIR Phase I 1986 Department of Health and Human Services
  3. RADIOIODINATED CONJUGATES FOR THERAPY AND DIAGNOSIS

    SBC: NEORX CORPORATION            Topic: n/a

    THE PURPOSE OF THIS CONTRACT PROPOSAL IS TO DEVELOP NEW RADIOIODINE-LABELED CONJUGATES FOR MONOCLONAL ANTIBODIES THAT CAN BE USED IN DIAGNOSIS AND THERAPY OF CANCER. THE GOAL OF OUR PROPOSED RESEARCH IS TO INVESTIGATE A NOVEL METHOD OF INTRODUCING HIGH SPECIFIC ACTIVITY RADIOIODINE INTO SOME SMALL MOLECULES WHICH CAN BE CONJUGATED TO MONOCLONAL ANTIBODIES. OUR APPROACH TO DEVELOP NEW CONJUGATES IS ...

    SBIR Phase II 1986 Department of Health and Human Services
  4. RADIORHENIUM ANTIBODIES FOR RADIOIMMUNOTHERAPY

    SBC: NEORX CORPORATION            Topic: n/a

    THE OBJECTIVE OF THIS PHASE I SBIR PROJECT IS TO DEVELOP A RE-186 AGENT SUITABLE FOR LABELING BIFUNCTIONAL CHELATING AGENT ANTIBODY CONJUGATES. ALTHOUGH CHEMICALLY SIMILAR TO TC-99M, APPLICATION OF RE-186 TO YIELD POTENTIAL THERAPEUTIC RADIOPHARMACEUTICALS PRESENTS PROBLEMS WHICH HAVE YET TO BE SOLVED. SPECIFICALLY, IT IS MUCH MORE DIFFICULT TO MAINTAIN RE IN REDUCED OXIDATION STATES THAN TC, AND ...

    SBIR Phase II 1986 Department of Health and Human Services
  5. THE PURPOSE OF THIS PROJECT IS TO LABEL MONOCLONAL ANTIBODIES WITH ASTATINE-211 FOR USE IN RADIO-IMMUNOTHERAPY.

    SBC: NEORX CORPORATION            Topic: n/a

    THE PURPOSE OF THIS PROJECT IS TO LABEL MONOCLONAL ANTIBODIES WITH ASTATINE-211 FOR USE IN RADIO-IMMUNOTHERAPY.THE GOAL OF THE PROPOSED RESEARCH IS TO DEVELOP A METHOD TO INCORPORATE ASTATINE INTO ANTIBODIES SUCH THAT THE ASTATINE LABILE IN VITRO OR IN VIVO. IN THE INVESTIGATION, TWO DIFFERENT APPROACHES TO LABELING WILL BE COMPARED. ONE APPROACH WILL BE DIRECT LABELING WITH ASTATINE; THE OTHER AP ...

    SBIR Phase I 1986 Department of Health and Human Services
  6. THE OBJECTIVE OF THIS PHASE I PROJECT IS TO DEVELOP AND EVALUATE A NOVEL METHOD FOR RADIOLABELING MONOCLONAL ANTI- BODIES WITH TECHNETIUM-99M FOR THE SPECIFIC DIAGNOSIS OF CANCER.

    SBC: NEORX CORPORATION            Topic: n/a

    THE OBJECTIVE OF THIS PHASE I PROJECT IS TO DEVELOP AND EVALUATE A NOVEL METHOD FOR RADIOLABELING MONOCLONAL ANTI- BODIES WITH TECHNETIUM-99M FOR THE SPECIFIC DIAGNOSIS OF CANCER. THE METHOD PROVIDES FOR A VERY EFFICIENT UPTAKE OF OFFERED TECHNETIUM TO THE HIGH SPECIFIC ACTIVITY REQUIRED FOR RADIOIMAGING. ANTIBODY PREPARED ACCORDING TO THE DESCRIBED METHOD RETAINS MOST OF ITS IMMUNOREACTIVITY, AND ...

    SBIR Phase I 1986 Department of Health and Human Services
  7. RHENIUM-188 HAS FAVORABLE PHYSICAL PROPERTIES AS A THERA- PEUTIC RADIONUCLIDE, T-1/2 OF 17.

    SBC: NEORX CORPORATION            Topic: n/a

    RHENIUM-188 HAS FAVORABLE PHYSICAL PROPERTIES AS A THERA- PEUTIC RADIONUCLIDE, T-1/2 OF 17.0 HOURS, EMAX BETA 2.2 MEV,AND EGAMMA 155 KEV. METHODOLOGY HAS BEEN DEVELOPED FOR CONJUGATION OF RHENIUM IN STABLE COMPLEXED FORM TO ANTIBODIES. THE OBJECTIVE OF THIS PROPOSAL IS TO DEVELOP THE TECHNOLOGY NECESSARY TO MAKE HIGH SPECIFIC ACTIVITY RE- 188 AVAILABLE FOR RADIOIMMUNOTHERAPY USING THE W-188/RE-188 ...

    SBIR Phase I 1986 Department of Health and Human Services
  8. THIS PROJECT CONCERNS THE DESIGN OF MEDFLOR, A DATABASE FOR ETHNOBOTANICAL INFORMATION TO BE USED IN SELECTING PLANTS WITH POTENTIAL USES IN MEDICINE.

    SBC: Naprotech Inc            Topic: n/a

    THIS PROJECT CONCERNS THE DESIGN OF MEDFLOR, A DATABASE FOR ETHNOBOTANICAL INFORMATION TO BE USED IN SELECTING PLANTS WITH POTENTIAL USES IN MEDICINE. DATAMAPS SPECIFIC TO THE BOTANICAL, MEDICAL, AND ANTHROPOLOGICAL ASPECTS OF THE DATA WILL BE CONSTRUCTED. SOME STRUCTURAL FEATURES AND SOFTWARE FROM THE NATURAL PRODUCTS DATABASE NAPRALERT WILL BE INCORPORATED, MAKING THE TWO DATABASES COMPATIBLE. A ...

    SBIR Phase I 1986 Department of Health and Human Services
  9. PARALYTIC SHELLFISH POISONING: NEW METHODS FOR ASSAY AND DEP

    SBC: Neushul Mariculture Inc.            Topic: n/a

    PARALYTIC SHELLFISH POISONING (PSP) IS A GROWING PUBLIC HEALTH PROBLEM. THE PRESENCE OF TOXINS IN SHELLFISH IS RATHER CRUDELY MEASURED BY INJECTING SHELLFISH EXTRACTS INTO MICE, AND RECORDING THE TIME THAT ELAPSES BETWEEN INJECTION AND DEATH. WE PROPOSE TO DEVELOP AN EASILY USED ASSAY TO DETERMINE THE PRESENCE OF TOXINS IN SHELLFISH AND USE BIOCHEMICAL AND PHYSIOLOGICAL APPROACHES IN DEVISING METH ...

    SBIR Phase II 1986 Department of Health and Human Services
  10. RETROVIRUSES ARE A RELATIVELY NEWLY RECOGNIZED GROUP OF RNA VIRUSES.

    SBC: Neushul Mariculture Inc.            Topic: n/a

    RETROVIRUSES ARE A RELATIVELY NEWLY RECOGNIZED GROUP OF RNA VIRUSES. MANY ARE ASSOCIATED WITH MALIGNANCIES IN MAMMALS, AND THE VIRUS THAT HAS BEEN IDENTIFIED IN CASES OF ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS) IS A RETROVIRUS. DUE TO THE SEVERITY OF AIDS, IT HAS BEEN PLACED AT THE TOP OF THE NATIONS'S HEALTH PRIORITIES. ANTIVIRAL AGENTS ARE BEING SOUGHT TO TREAT CASES OF AIDS AND OTHER RETROVIR ...

    SBIR Phase I 1986 Department of Health and Human Services

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