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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Leptospirosis Vaccine Development

    SBC: Luna Bioscience, Inc.            Topic: NIAID

    Summary/abstract. Leptospirosis is a globally important neglected disease caused by pathogenic Leptospira. It is estimated to cause more than 1 million global cases annually with a 5-20% case-fatality rate, significant morbidity, and important public health consequences. Currently there is no safe and effective vaccine to prevent human leptospirosis. LeptoX, Inc. proposes to develop the first huma ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Water-based liquid embolic agent for the treatment of vascular rich tumors

    SBC: AQUATEX MEDICAL INC            Topic: 102

    AquaTeX Medical is developing a novel liquid embolic material (LEM) - Aqua Embolic System (AES) - to improve cancer treatment. AES is designed to occlude feeding vessels of hypervascular tumors with superior efficacy and excellent biocompatibility as compared to other trans-arterial embolization (TAE) materials.TAE is a catheter-based treatment to treat hypervascular tumors. Embolic materials are ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Low Cost Imaging In The mm Wave Region Using Plasma Waves in High Mobility Transistor

    SBC: BRIMROSE TECHNOLOGY CORP            Topic: CBD22BT001

    In this work, we propose to develop low-cost, high sensitivity high electron mobility transistor-based W-band millimeter wave focal plane array/camera based on mature ternary III-V epitaxial materials of InAlAs on top of InP substrate. The plasma-wave detector uses well established mature technology of high electron mobility transistors which allows future integration and reduces cost. The detecto ...

    STTR Phase I 2023 Department of DefenseOffice for Chemical and Biological Defense
  4. AIVIS: Next Generation Vigilant Information Seeking Artificial Intelligence-based Clinical Decision Support for Sepsis

    SBC: HEALCISIO INC            Topic: NIAID

    Abstract Sepsis, a heterogeneous syndrome characterized by whole-body inflammation caused by the body's response to an infection, is the most expensive and deadly condition treated in hospitals, with over 270,000 cases of sepsis-related deaths in the U.S. alone. The cornerstones of optimal sepsis care are early recognition accompanied by appropriate antimicrobial therapy, and use of evidence-based ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Precision Glycoengineering of an HCV Envelope-Based Nanoparticle Vaccine

    SBC: NeuImmune, Inc.            Topic: NIAID

    ABSTRACTGlobally, more than 71 million people are infected with Hepatitis C virus (HCV), with 1-2 million new infections occurring each year. This major health concern necessitates the development of an effective vaccine. Since HCV rapidly accumulates mutations, vaccines must elicit the production of broadly neutralizing antibodies (bnAbs) in a reproducible fashion. The viral envelope E1E2 glycopr ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  6. Controlled Gradient Release of Biologics: Enhanced Nerve Conduit for Long‐Gap Injury Repair

    SBC: Pioneer Neurotech Inc.            Topic: 106

    Project Summary / Abstract Nerve injuries arising from trauma, disease, or as a surgical necessity, lead most often to permanent loss of some or all functions mediated by the injured nerves. 50,000 peripheral nerve procedures are performed every year in the US, and 300,000 across Europe. After complete transection of a nerve, the optimal clinical procedure for nerve repair remains the surgical end ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  7. Translational development of novel CRISPR approach to treat genomic duplications

    SBC: MYOFINITY BIOSCIENCES INC            Topic: NIAMS

    PROJECT ABSTRACT The goal of this Phase I STTR project is to accomplish key milestones in commercializing a novel SaCas9 nickase-based system (CRD-002) to treat dystrophinopathies in order to restore the production of healthy, endogenous full-length dystrophin protein otherwise compromised by duplication mutations. Duchenne muscular dystrophy (DMD) is characterized by progressive muscle loss and c ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  8. Exploiting translation elongation for improved biologics manufacturing

    SBC: CODOMAX INC.            Topic: NCATS

    Abstract – Codomax has developed a codon engineering platform that enables bespoke, high-yield, cost- effective protein manufacturing by leveraging a newly discovered translational regulatory system in industrially relevant cell systems. Protein manufacturing has a current estimated market size of over $300 billion, distributed among the areas of antibodies and biologic therapeutics, biotechnolo ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  9. Closed-loop laryngeal pacing for voice restoration

    SBC: RIPPLE LLC            Topic: NIDCD

    Project Summary and Abstract The most common neurogenic voice disorder is unilateral vocal fold paralysis (UVFP), which can substantially reduce quality of life. Current available surgical treatments offer only temporary improvement in voice through placement of resorbable materials or involve permanent, invasive alteration of the larynx that incompletely restores voice and often requires revision ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  10. Therapeutic targeting of FKBP51 for the prevention of stress-induced preterm birth

    SBC: DARE BIOSCIENCE, INC.            Topic: NICHD

    In the United States, one in ten babies is born prematurely. The earlier in pregnancy a baby is born, the more likely they will have an extended hospital stay, as well as serious health complications such as respiratory distress syndrome, necrotizing enterocolitis, deafness, vision problems and cerebral palsy. Maternal stress is a well-established risk factor for preterm birth, and recent studies ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
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