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SBC: OASIS PHARMACEUTICALS, LLC Topic: NHLBI
Idiopathic pulmonary fibrosisIPFthe most common of the interstitial lung diseasesoccurs in aboutpeoplewithnew cases diagnosed annually in the USThe typical clinical course is a progressive fibrotic disease characterized by scarring and `honeycombingandaposof the lungs causing an irreversible loss of the tissueandapos s ability to transport oxygenCo morbid pulmonary hypertension is commonly seen in ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
TAPS-ESP: Tobacco, Alcohol, Prescription Drug, and Illicit Substance Use- Electronic Spanish Platform: Technologies to Increase Screening in Primary Care to Reduce Behavioral Health DisparitiesSBC: COG ANALYTICS, LLC Topic: 102
ABSTRACTTAPS ESP Language accessibility and cultural awareness are essential elements of quality healthcareLimited English ProficiencyLEPindividuals are less likely to self identify a need for behavioral health serviceswhich results in longer duration of untreated disordersAccurate identificationdiagnosisand treatment are entirely dependent on a linguistically accurate screening and assessmentespe ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
Developing an efficient E-cigarette aerosol generation and exposure system for rodent models with aerosol characteristics equivalent to those inhaled by E-cigarette usersSBC: AUTOMATE SCIENTIFIC, INC. Topic: NIDA
Abstract E cigaretteE ciguse has rapidly proliferated worldwideIt is speculated that E cig use may exceed conventional cigarette use withinyearsCigarette smoking is the leading preventable cause of death and disabilityAs E cigs are a relatively new productstudies are needed to determine their long term detrimental effectssome of which may be similar to the long term detrimental effects of nicotine ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
Inter-examiner Agreement of a Novel Device for the Measurement of Cervical Dilation in Labor: A Randomized Controlled TrialSBC: Elm Tree Medical Inc. Topic: NICHD
Measurement of cervical dilation during late pregnancy and labor informs decisions in the management of labor and deliveryPrior published research suggests that practitioners are onlytoaccurate when judging cervical simulatorsWhen measuring laboring womentwo practitionersandaposmeasurements agree onlyof the timeDrEva Martin of Elm Tree Medical Incdeveloped a novel deviceDilaCheckto enable practiti ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: Fawkes Biotechnology, LLC Topic: 100
Traumatic brain injuryTBIis a substantial health care issue affecting both civilian and military populationsAlthough extremes of head injury are recognizablemild to moderate TBImmTBIis more difficult to diagnose leading to a need for the identification of circulating biomarkers of brain injury that may facilitate early identificationUsing a rat model of TBI we identified a novel marker of neuronal ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: MICROBIOTIX, INC. Topic: R
ABSTRACT The Zika virusZIKVis the cause of an explosive pandemic of infections across South and Central Americathe Caribbeanand the southeastern region of the United StatesZIKV is a flavivirusa family of small positive strand RNA viruses that includes Dengue virusDENVWest Nile virusWNVYellow fever virusYFVand hepatitis C virusHCVZIKV is transmitted to humans by mosquitoes of the Aedes genusFor the ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: C. Light Technologies, Inc. Topic: NINDS
Abstract The goal of this project is to validate an innovativehighly sensitive retinal eye tracking technologythe tracking scanning laser ophthalmoscopeTSLOas a prognostic and monitoring tool for neurodegenerative disordersnamely multiple sclerosisMSThe applications of effective treatments for multiple sclerosis are constrained bythe absence of methods for early detection andquantitativehighly sen ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: Op-T-Mune, Inc Topic: NIDDK
AbstractA major shortfall in clinical care for diabetes is a rapid and accurate screen for progression to diseaseCurrent criteria involve HLA haplotypeand the presence of auto antibodiesAAGenome wide associated studiesGWASrevealed only immune associated genes including HLA as T D predictorsThe ability to differentiate from other diseases was very limitedPre typediabetesp T Dis now being identified ...STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: DFH Pharma, Inc Topic: 400
Project SummaryDespite advances in the development of HIV drugs there remains a need for new therapiesToxicities associated with long term use of many of the approved HIV drugs coupled with the development of resistance drives the need for new and novel antiviralsMaturation inhibitorsMIsrepresent one such class of HIV therapiesHIV maturation inhibitors block virus replication by disrupting the con ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: Silicon Insite, Inc. Topic: 400
Drug discovery is challenging and expensiveespecially in the phase of lead optimization whichpredicts binding to a targetComputational approaches can add substantial valueComputingrelative binding free energiesRBFEbetween congeneric molecules using molecular dynamicsMDgreatly reduces the search space and considerably improves convergenceThe Silicon TherapeuticsSTXINSITE platform uses an RBFE proto ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health