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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 171 - 180 of 207712 results
  1. Targeting lipid rafts for treatment of asthma

    SBC: RAFT PHARMACEUTICALS LLC            Topic: NIAID

    PROJECT SUMMARY Patients with severe asthma who display persistent bronchoconstriction and/or reduced lung function despite available bronchodilator, corticosteroid and Th2-targeting therapy develop significant morbidity, which severely impacts their quality of life owing to persistent symptoms, as well as frequent and life-threatening exacerbations. Aspects of severe asthma currently not managed ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Framewise Integrated Real-Time MRI Monitoring (FIRMM) software commercialization readiness for clinical care

    SBC: TURING MEDICAL TECHNOLOGIES INC            Topic: 102

    Project Abstract/SummaryMotion related artifacts are a significant source of cost to the healthcare system. With over 12,000 MRI scanners in the U.S. and estimates that $434,000 are lost per scanner each year, motion in MRIs is costing our health care system approximately $4B yearly. Our FDA-cleared software solution Framewise Integrated Real- Time MRI Monitoring (FIRMM) mitigates data lost due to ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Development of MRS-2541, a methionyl-tRNA synthetase inhibitor, for Gram positive bacterial infections.

    SBC: TSRL, INC.            Topic: NIAID

    The objective of this grant is the preclinical development of MRS-2541, a novel antibiotic structure targeting Gram+ bacteria by a new mechanism of action. MRS-2541 inhibits bacterial methionyl- tRNA synthetase required for bacterial protein synthesis, which is very different from its mammalian counterpart. MRS-2541 is the result of an arduous testing cascade of over 500 compounds requiring broad- ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Sonodynamic therapy using MRI-guided focused ultrasound in combination with 5-aminolevulinic acid to treat recurrent glioblastoma multiforme

    SBC: SONALASENSE, INC.            Topic: 102

    PROJECT SUMMARY Glioblastoma multiforme (GBM) is a rare and deadly cancer. First line treatment for GBM includes maximal surgical resection with radiotherapy administered post-surgery, and concomitant administration of adjuvant temozolomide. Tumor recurrence is nearly inevitable due to the microscopic, infiltrating cells that are found centimeters from the margin of visible tumor mass. There is cu ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Spinal Reflex Conditioning System for Enhancing Motor Function Recovery After Incomplete Spinal Cord Injury

    SBC: BIOCIRCUIT TECHNOLOGIES INC            Topic: 999

    Project Summary Spinal Cord Injury (SCI) affects ~300,000 people in the US, with 11,000 new cases/year. After SCI, spinal reflex function becomes abnormal, contributing to motor impairments and spasticity that affects 65-78% of people with SCI. Thus, restoring the function of spinal reflex pathways is a major therapeutic goal. Current therapies are only moderately successful; motor function often ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  6. Regulatory clearance of a rehabilitation system for individuals with upper limb loss

    SBC: INFINITE BIOMEDICAL TECHNOLOGIES, LLC            Topic: 105

    ABSTRACT Our work to date has resulted in the development of several technologies focused on improving the lives of individuals with upper-limb loss (ULL). First, our Sense pattern recognition control system (and associated Element low-profile surface EMG electrodes and FlexCell flexible lithium-polymer batteries) can interface with most myoelectric hands, wrists, and elbows on the market. Second, ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  7. Novel Extracorporeal Device 'Amytrapper' To Remove Beta Amyloid In Alzheimer'sDisease

    SBC: Recombinant Technologies LLC            Topic: NIA

    Abstract Alzheimer’s disease is the most common cause of dementia and fourth most common cause of death. Amyloid-beta (Aβ) plays a crucial role in initiation and progression of Alzheimer’s disease (AD). Removal of circulating Aβ would shift the equilibrium in Aβ levels between brain and blood towards blood. This shift would deplete brain amyloid levels and improve memory. Three commercial m ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  8. Fiber-fed Pulsed Plasma Thruster (FPPT) for Active Debris Removal

    SBC: CU AEROSPACE L.L.C.            Topic: Z8

    Through a NASA Phase II SBIR Contract # 80NSSC18C0063, CUA developed the 1.7U-32J Fiber-fed Pulsed Plasma Thruster (FPPT), which achieves scalable propellant throughput with its fiber-fed design. During the development process, subsystems were improved and miniaturized. These include the high-density energy storage via multi-layer ceramic (MLCC) capacitors (100x life tested), high-thrust, low-eros ...

    SBIR Phase II 2023 National Aeronautics and Space Administration
  9. Generating Requirements Evidence with Analysis and System-level Enforcement (GREASE)

    SBC: GALOIS, INC.            Topic: HR001121S000708

    The Generating Requirements Evidence with Analysis and System-level Enforcement (GREASE) project will develop a static binary verifier that generates evidence that COTS software components satisfy their requirements. The GREASE tool will accelerate both (1) the safe and high-assurance integration of COTS components into systems, and (2) the generation of assurance cases for the certification of sy ...

    SBIR Phase II 2023 Department of DefenseDefense Advanced Research Projects Agency
  10. Deep Learning Translation of Unsafe Source and Binary into Safe Software

    SBC: CODE 13 SECURITY            Topic: HR001121S000710

    By virtue of a Phase I Defense Advanced Research Projects Agency (DARPA) Small Business Innovative Research (SBIR) contract, Code 13 Security (doing business as Dark Sky Technology) has developed a Technical Readiness Level (TRL) 5 technology to translate type-unsafe source and binary software into the type-safe language Rust. The design of this system is innovative in its use of machine learning ...

    SBIR Phase II 2023 Department of DefenseDefense Advanced Research Projects Agency
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