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SBC: SIGNAL SOLUTIONS, LLC Topic: NHLBI
ABSTRACTSignal Solutions has developed a novelnoninvasive and automated piezoelectric based sleep detection system for high throughput studies of sleep in miceand has recently expanded to rat studies as wellThe respiratory signal detected by the piezo sensor during sleep can be applied to investigate important health conditions including respiratory depression due to disease or drug useand other s ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
Chronic intrapulmonary delivery of a novel small molecule Wnt/beta-catenin inhibitor for Idiopathic Pulmonary FibrosisSBC: BETA CAT PHARMACEUTICALS, INC. Topic: NHLBI
Project Summary Idiopathic pulmonary fibrosisIPFis a devastatingprogressive disease with no known cure and no treatment that convincingly alters the disease course or significantly improves mortalityThe objective of this proposal is the development of nebulized delivery of the small molecule inhibitor of Wntcatenin signalingBCfor Idiopathic Pulmonary FibrosisPre clinical studies in rodentsdogsand ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: MICROBIOTIX, INC. Topic: R
ABSTRACT The Zika virusZIKVis the cause of an explosive pandemic of infections across South and Central Americathe Caribbeanand the southeastern region of the United StatesZIKV is a flavivirusa family of small positive strand RNA viruses that includes Dengue virusDENVWest Nile virusWNVYellow fever virusYFVand hepatitis C virusHCVZIKV is transmitted to humans by mosquitoes of the Aedes genusFor the ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
Building an evidentiary case for circulating GHBP as a biomarker for drug-associated stunting of growthSBC: ReveraGen BioPharma, Inc. Topic: NICHD
There is increasing interest in the use of biomarkers in clinical drug developmentwith much of thest Century Cures Act focused on encouraging this approachIdeallybiomarkers could provide and acute and objective read out of drug mechanism of actionpharmacodynamic biomarkersor prediction of later clinical benefit or harmsurrogate outcome measureHoweververy few biomarkers have been validated for rout ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: IMMvention Therapeutix, Inc. Topic: NIAID
Summary Influenza virusa member of the orthomyxovirus familyhas three different types that infect humansABand CTypes A and B produce annual epidemicsand type A influenzawhich resides asymptomatically in birdscan cause pandemic infections in humansIn addition to common flu like symptomse gfeverchillsmalaisemuscle painin susceptible populations influenza can induce potentially fatal secondary compli ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: RITHIM BIOLOGICS INC Topic: NCATS
ABSTRACT Atrial fibrillationAFis the most common rhythm disturbance in the US and other developed countriesAF significantly affects the lives of the afflictedcausing symptoms that range from palpitations to fatigueweakness and activity intoleranceand substantially increasing the risks of strokecongestive heart failure and deathThe impact on public health is substantialwith more thanhospital admiss ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: SERPLUS TECHNOLOGY LLC Topic: NIAID
PROJECT SUMMARY Asthma exacerbations are a major cause of ER visits and hospitalizations with annual direct costs of approximately $billionyear in the USAViral infectionsin particular rhinoviralRVinfectionsare a major precipitant of asthma exacerbations in allergic asthmaticsAs there are overRV serotypes andfor nowno RV vaccinenovel strategies to inhibit RV induced airway inflammation are needed t ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: SPIKEGADGETS, INC. Topic: 101
Psychiatric disorders give rise to aberrant patterns of activity within the complex neural circuits of our brainsYetthe exact nature of these abnormal patterns is often unknown to developers of new treatmentsThe goal of this project is to enable circuit oriented research of neuropsychiatric diseases using rodent disease modelsThe long term objective is to catalyze the discovery of new therapeutic ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: GOBLUE INTERNATIONAL, LLC Topic: 104
Abstract Worry is a habitual thought process that is observed in individuals with anxiety disordersA leading theory posits that although worrying may be unpleasantthe immediate emotions that are avoided by concentrating on worry are often perceived as more aversiveegfearangergriefFrom a mechanistic perspectiveworry is thought to be learned and reinforced in a similar manner to other types of opera ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
Mitigation of Acute and Chronic Kidney Injuries by Systemic Infusion of Adipose-Derived Soluble Therapeutic Factor ConcentrateSBC: NeuroFx, Inc. Topic: 300
ABSTRACT Acute kidney injuryAKIis a syndrome characterized by rapid loss of the kidneyandapos s excretory functionAKI is the leading cause of nephrology consultation and results inmillion hospital admissions a yearThe socioeconomic impact of AKI is significantresulting in $billion cost to the health care systemDespite the high rate of incidence of AKIno therapy currently existsother than supportiv ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health