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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. N/A

    SBC: BIOCACHE PHARMACEUTICALS, INC.            Topic: N/A

    N/A

    STTR Phase I 2000 Department of Health and Human ServicesNational Institutes of Health
  2. NANOFIBER TECHNOLOGY IN SMALL-DIAMETER VASCULAR GRAFTS

    SBC: BIOMOD SURFACES            Topic: N/A

    There is no small-diameter vascular prosthesis that is capable of emulating the biologic and physical properties of the normal arterial wall. The goal of this proposal is to develop a small-diameter prosthetic vascular graft using nanofiber technology. Our hypothesis is creating a nanofibrous vascular graft by electrospinning an ionic polyurethane will result in a graft that possesses properties s ...

    STTR Phase I 2002 Department of Health and Human ServicesNational Institutes of Health
  3. Development of Infection-Resistant Suture Materials

    SBC: BIOSURFACES INC            Topic: N/A

    DESCRIPTION (provided by applicant): Infection remains as one of the major complications associated with utilizing biomaterials. Surgical site infections account for approximately 14-16% of the 2.4-million nosocomial infections in the United States, with these infections resulting in increased patient morbidity and mortality. The inherent bulk properties of various biomaterials, including those ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  4. A Bioactive Prosthetic Vascular Graft

    SBC: BIOSURFACES INC            Topic: N/A

    DESCRIPTION (provided by applicant): Over 60,000 prosthetic grafts, which are comprised of either polyethylene terephthalate (polyester) or expanded polytetrafluoroethylene (ePTFE), are implanted in the United States each year. Medium (6-8mm) and small (l t5mm) internal diameter (I.D.) prosthetic arterial grafts continue to have unacceptably high failure rates when used in the clinical setting. T ...

    STTR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  5. Hydroxyl radical mapping of protein interfaces

    SBC: EXSAR CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): Identifying amino acid residues of a protein that form the binding site for a drug, or that are present at the interface in a protein-protein complex are difficult to identify from the crystal structures of the individual partner proteins. Carta Proteomics is committed to the premise that monitoring isotope exchange in ...

    STTR Phase I 2001 Department of Health and Human ServicesNational Institutes of Health
  6. Vaccine-enhanced DLI to prevent cancer recurrence after stem cell transplantation

    SBC: CERUS CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): Delayed reconstitution of antigen-specific immunity following allogeneic hematopoietic stem cell transplantation (HSCT) predisposes patients to opportunistic infections and tumor recurrence. To address these problems, we are developing a vaccination methodology using a non-replicating but highly immunogenic Listeria monocytogenes (Lm) vector. When an Lm vaccine ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  7. DRUG DISCOVERY FOR TREATMENT OF OBESITY

    SBC: Chemdiv, Inc.            Topic: N/A

    The goal of this research project is to define the structure and radioactive label for ligands that will permit quantitative measurement of serotonin transporter (5-HTT) sites in living brain by external imaging with positron or single-photon emission tomography (PET or SPECT). The serotonin transporter is known to play a role in several physiological and pathophysiological processes, especially i ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  8. Identification of Novel ACTH small molecule Antagonists

    SBC: Chemdiv, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The production of adrenal gland hormones, including cortisol and androgens, is regulated by pituitary ACTH (adrenocorticotropin hormone), which acts via the melanocortin-2 receptor (MC2R) to stimulate steroid production. The ability to antagonize ACTH action would greatly facilitate the care of several clinical conditions, including congenital adrenal hyperplas ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  9. Spinal Fusion Using Adipose Derived Adult Stem Cells

    SBC: Cognate Therapeutics, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Back pain afflicts over 75% of Americans during their lifetime and 2% of the American work force suffers a back injury on the job each year. Spinal fusion is the orthopedic procedure routinely used to treat back pain in patients suffering from degenerative disc disease, spinal stenosis, scoliosis, and spinal fracture; however, procedure failure rates range betw ...

    STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  10. Mammal Cecropins as Antibiotics for Corneal Infections

    SBC: Cytopro, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The emerging bacterial infections that are resistant to the current antibiotic arsenal have accelerated search for therapeutic agents with a novel mechanism of action. Recent studies suggest that the gene-encoded peptide antibiotics may hold great promise as a new generation of therapeutic agents. These agents have the potential to become medications used on a ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
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