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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Development of a protein palmitoylation assay to monitor treatment of CLN1 Batten Disease

    SBC: Circumvent Pharmaceuticals            Topic: NICHD

    SummaryIn the Specific Aims outlined by the following proposal for an NIH SBIR Phase 1 project, we will use a multi-faceted approach to identify key substrates for targeted assay development to monitor therapy in for CLN1 Batten Disease (CLN1). CLN1 is an ultra-rare neurodegenerative disease that affects children with autosomal recessive mutations in the gene for palmitoyl-protein thioesterase 1 ( ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  2. 3D Printed Silicon Nitride Porous PEEK Composite Spinal Cages for Anti-Infection

    SBC: SINTX TECHNOLOGIES, INC.            Topic: 400

    PROJECT SUMMARY—When neck and back pain becomes intractable, spinal fusion is the gold-standard treatment. However, up to 12% of these fusions fail due to infection, resulting in substantial personal and financial costs. In most cases, these infections are associated with the hardware used to stabilize the fusion. Traditionally molded or machined polyether ether ketone (PEEK) cages are widely us ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  3. High-throughput Single Cell Co-assay of Histone Modifications and Transcriptome

    SBC: EPIGENOME TECHNOLOGIES, INC.            Topic: 400

    AbstractEpigenome analysis can help dissect the transcriptional regulatory sequences that control spatiotemporal patterns of gene expression during anima development and disease pathogenesis, but a major challenge to epigenome analysis is the heterogeneity of primary tissues. Conventional epigenome assays that take bulk tissues as input only produce population average signals. To address this majo ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  4. Smart, integrated well-plates for ultra-high-throughput screening of excitation-contraction coupling in tissues

    SBC: FORCYTE BIOTECHNOLOGIES, INC.            Topic: NIGMS

    Project Summary Heart disease remains the leading cause of mortality in the world and, drug-induced cardiotoxicity is a major cause of drug failure and withdrawal from the clinic or the market, contributing to the poor overall success rate of drug development programs. In vitro models of cardiac contractility have the potential to generate predictive data earlier in the pipeline to reduce later-st ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  5. Polymer use in Preservation of Tissue Perfusion to Address Sepsis

    SBC: PERFUSION MEDICAL LLC            Topic: 300

    Perfusion Medical is commercializing a novel pipeline product called PEG-20k IV Solution. The company believes this may be the first therapeutic to directly treat lethal complications of sepsis, and as such, support new thinking on the basic mechanisms of the disease. Sepsis or septic syndrome leads to a spectrum of illnesses and occurs at a frequency of 1.7 million people in the US each year and ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  6. Engineered Cyclodextrins to Address 7-ketocholesterol-Associated Diseases ofAging

    SBC: UNDERDOG PHARMACEUTICALS, INC.            Topic: NIA

    Project Summary/Abstract Underdog Pharmaceuticals, Inc. (UDP), in collaboration with the SENS Research Foundation (SRF), aims to demonstrate that 7-ketocholesterol (7KC) is elevated in red blood cells (RBCs) in Atherosclerosis and Alzheimer’s disease. 7KC is primarily created by non-enzymatic oxidation of cholesterol. With only a few exceptions, human tissues lack the ability to metabolize or ex ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  7. Bronchoscopic lung navigation system for accurately excising lung nodules

    SBC: Navigation Sciences, Inc.            Topic: 102

    ABSTRACT The long-term goal of this project is to develop and commercialize a navigation system that can accurately determine margins in real-time during surgery for lung cancer. Surgery is currently the standard of care for early stage lung cancer. A critical challenge is to reliably identify small, early-stage tumors and resect them with sufficient margins (distance between the edge of tumor and ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  8. Development of perivascular space mapping toolset as a diagnostic aid for Alzheimer's disease

    SBC: NEUROSCOPE INC.            Topic: NIA

    Project Summary Alzheimer’s disease (AD) is a devastating disease that affects millions of Americans and imposes a huge socio- economic burden. AD-related cognitive decline is associated with the accumulation of Aβ (Amyloid beta) plaques and neurofibrillary tangles of hyperphosphorylated tau protein, which are insufficiently cleared and degraded by mechanisms such as the glia-lymphatic system o ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  9. Long-lived Platform Development for Exonuclease-Based Sequencing

    SBC: ELECTRONIC BIOSCIENCES, INC.            Topic: 172

    Project Summary During this project, Electronic BioSicences (EBS) and Professor Meni Wanunu (at Northeastern University) will develop a true single-molecule, direct, long-lived, RNA sequencer. The developed RNA sequencer will be capable of sequencing RNA with high-accuracy (andgt;99%), as well as iteratively sequencing various samples and quantitatively profiling the RNA content of a given sample, ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  10. A novel, hand-held, exhaled breath condensate sampler for the clinical research market; applications for asthma, pulmonary injury and inflammation.

    SBC: SENSIT VENTURES, INC.            Topic: NIEHS

    ABSTRACTExhaled breath is one of the most non-invasive human effluents that can be captured and analyzed, and yet it has minimal presence as a common clinical endpoint measurement in any branch of modern medicine. There has been a persistent technology gap for both breath sampling and breath analysis, despite the many vulnerable patient populations and age groups that could be aided by its use. Ex ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
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