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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. A novel role for Reelin therapeutics in inflammatory bowel disease

    SBC: REELIN THERAPEUTICS, INC.            Topic: 300

    Abstract Factors that contribute to the onset of inflammatory bowel disease (IBD) remain incompletely understood. Although specific genetic factors may increase risk, most IBD cannot be readily explained based on genetics. Dysbiosis in intestinal microbiomes also has been implicated. Once IBD is established, chronic inflammation is a central hallmark and also a major target for therapy. Both forms ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  2. Development of an irreversible covalent inhibitor of FMS-like tyrosine kinase receptor 3 for treating acute myeloid leukemia

    SBC: BRIDGENE BIOSCIENCES INC            Topic: 102

    PROJECT SUMMARY Acute myeloid leukemia (AML), a malignant disease of hematopoietic precursor cells in the bone marrow, is one of the most common cancers in adults accounting for 1% of all cancers. AML is typically diagnosed later in life with individuals 60 and older having a long-term survival rate of merely 5-15%. Cytogenic analysis of the abnormal cells at the time of diagnosis has proven to be ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  3. Development of a Novel Therapeutic Transporter to Treat Metastatic Cancers

    SBC: CYTONUS THERAPEUTICS INC            Topic: NCI

    There is critical need for therapeutic delivery devices that can be administered intravenously (IV), and effectively home to and deliver therapeutic agents to diseased tissues, while maintaining patient safety. Cytonus Therapeutics, in collaboration with UC San Diegoandapos;s Moores Cancer Center, has pioneered a unique, drug transporter system with potential to treat to a wide range of cancers in ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  4. FES-Rowing: Preventing the Secondary Conditions of Paralysis Through Vigorous Exercise

    SBC: Myolyn, LLC            Topic: NICHD

    PROJECT SUMMARY/ABSTRACT Lack of exercise is a major cause of secondary health conditions, especially for people with paralysis, for whom participation in physical activity is especially difficult. Hybrid functional electrical stimulation (H- FES) exercise enables vigorous, total body physical activity for people with paralysis. However, existing H-FES devices are neither affordable nor accessible ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  5. STING Activators as Therapy for Cancer

    SBC: STINGINN, LLC            Topic: 101

    PROJECT SUMMARY The ability of dying cells to activate antigen presenting cells (APCs) is carefully controlled to avoid unwarranted inflammatory responses. Thus, tumor cells avoid aggravating APCs by efficiently simulating regular dying cells which following phagocytosis do not trigger inflammatory responses required for efficient cytotoxic T lymphocyte (CTL) priming. However, dying tumor cells co ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  6. Intrapartum Transabdominal Fetal Pulse Oximetry: Demonstration in Ewe Models

    SBC: Storx Technologies, Inc.            Topic: NICHD

    Project Summary Despite significant cost and clear evidence of health risks associated with Cesarean section surgeries, an unnecessarily large number of infants are delivered via Cesarean section (C- Section) surgeries. The high rate of C-section in the US, relative to globally accepted norms, and the associated additional cost and complications are in part, due to high false positive rate of intr ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  7. Efficacy of a novel small-molecule splicing modulator in chronic lymphocytic leukemia (CLL)

    SBC: Wildflower Biopharma Inc            Topic: 102

    Project Summary/Abstract Chronic lymphocytic leukemia (CLL) is the most prevalent adult leukemia in Western countries. Despite recent treatment advances, CLL remains incurable. In the era of emerging targeted therapies, disease progression and relapse increasingly are key challenges faced by CLL patients. Therefore, there is an ongoing need for the identification of targetable vulnerabilities in t ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  8. Full Mueller Matrix Characterization of Imaged Samples using Digital Holography

    SBC: POLARIS SENSOR TECHNOLOGIES INC            Topic: AF18AT007

    The Phase II effort will be to clearly demonstrate the feasibility and build a prototype of a noncontact, high-quality holographic polarimetry system with pixel level depth and Mueller matrix information with a user-friendly interface to image and display this data. The measurements of each data product will be validated with trusted truth samples. The system will be reproducible and will have a d ...

    STTR Phase II 2019 Department of DefenseAir Force
  9. Biological Microdosimetry System

    SBC: QUINC.TECH INC.            Topic: AF18AT001

    The Biomagnetics Micro Dosimetry System (BMDS) program will design, model, and simulate a microdosimetry system that can measure and create a three dimensional map of weak radiofrequency signals in biological organisms. The heart of the BMDS project is the front end that delivers very sensitive, broad band measurements with high spatial resolution. The front end is a valuable tool in the investiga ...

    STTR Phase II 2019 Department of DefenseAir Force
  10. High Power Density Dual Rotor Permanent Magnet Motor with Integrated Cooling and Drive for Aircraft Propulsion

    SBC: Advanced Magnet Lab, Inc.            Topic: 1

    There is a critical need for electrification of transportation systems. The proposed technology enables the development of very high-power density permanent magnet motors, which when coupled to an integrated SiC drive allows for an overall specific power beyond 12 kW/kg. The proposed concept relies on the tight integration of a high-power density dual-rotor permanent magnet motor, high power densi ...

    STTR Phase I 2020 Department of EnergyARPA-E
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