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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

Displaying 1811 - 1820 of 173942 results
  1. Demonstrating Utility of a Non-Infectious Minute Virus of Mice-Virus Like Particle for Predicting Viral Clearance during Biopharmaceutical Process Development

    SBC: MOCKV SOLUTIONS INC.            Topic: NCATS

    PROJECT SUMMARY ABSTRACT MockV SolutionsIncMockVis an early stage company creating viral surrogate tools that solve the unmet needs of scientists as they develop techniques in a variety of fields that currently rely on expensive and logistically challenging live virusesWe are currently focused on developing a novel series of assay kits which will enable biopharmaceutical scientists to study the ef ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. A Computer Model of Renal Physiology for use as a FDA Medical Device Development Tool

    SBC: HC Simulation, LLC            Topic: FDA

    The purpose of this proposal is to develop a validated physiological model of the human physiologyespecially the cardio renal axisfor submission to the FDA Medical Device Development Tool pilot programThe model will be used to aid in the development and regulation of medical devices designed to treat hypertensionExamples include devices for renal nerve ablationelectrical stimulation of the carotid ...

    SBIR Phase II 2018 Department of Health and Human Services
  3. A Resonator for Pulsed ODNP Spectroscopy to Study Surface Hydration Dynamics

    SBC: BRIDGE 12 TECHNOLOGIES, INC.            Topic: 400

    Project SummaryAbstractThe proposed research focuses on the development of a turn key resonator for liquid state Overhauser Dynamic Nuclear PolarizationODNPspectroscopy to study the site specific translational dynamics of water molecules located at the interface of bio macromolecules such as membrane proteinsIt will allow researchers to readily perform ODNP experiments in a state of the art commer ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. BT-11: A First-in-class Oral Therapeutic for Inflammatory Bowel Disease

    SBC: Biotherapeutics, Inc.            Topic: NIAID

    BTA First in class Oral Therapeutic for Inflammatory Bowel Disease Biotherapeutics IncBTIdevelops oral first in class therapeutics for autoimmune diseasesBTa lead compound for treating inflammatory bowel diseaseIBDbelongs to a new chemotype and targets the novel Lanthionine Synthetase C LikeLANCLpathwayBTI will file an IND for BTinmonthsSignificanceIBD afflicts overmillion Americans andmillion peo ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Humanized EMAP II mAb as a Novel Therapy for Viral-Associated Lung Injury

    SBC: Allinaire Therapeutics, LLC            Topic: NHLBI

    Summary Abstract The ultimate goal of this project is the validation of a humanized endothelial monocyteactivating protein IIEMAP IIneutralizing monoclonal antibodymAbfor progression to clinical evaluation as a novel treatment for patients with influenza associated lung injuryInfection with influenza virusIAVremains a major world wide health threat to high risk populations including the young and ...

    STTR Phase I 2018 Department of Health and Human Services
  6. Using Augmented Reality To Make Cardiac Ablation Procedures Simpler and Safer

    SBC: SENTIAR, INC.            Topic: NHLBI

    Abstract The goal of this SBIR FastTrack application is to deliver an augmented realityARplatform technology that displays an interactiveD cardiac hologram to make ablation procedures simpler and saferWorld widecardiac ablations are used as therapy formillion arrhythmia patients every yearThere ishoweversignificant skill required to perform these procedures and only a handful of cases can be perfo ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Powerful Solid-State Sources to Enable Advanced EPR and DNP-NMR Measurements

    SBC: Virginia Diodes, Inc.            Topic: 400

    VDI Project Summary AbstractThe NIH Division of Cell Biology and Biophysics supports studies of the biological macromolecules that affect the function and structure of living cellsand often play a role in diseaseWithin the realm of biophysicsone of the most important tools to study the structure and interactions of these molecules is nuclear magnetic resonanceNMRFor exampleNMR has been used to stu ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Preclinical Testing of Splice Modulating Oligonucleotides Targeting SCN8A to Treat Dravet Syndrome

    SBC: LifeSplice Pharma            Topic: 105

    Dravet Spectrum disorders resulting from SCN A loss of functionLOFmutations include febrile seizuresgeneralized epilepsy with febrile seizure plusGEFSand Dravet SyndromeDSin order of severityDS symptoms begin in infancy and lead to progressive developmental and behavioral impairments along with characteristic recurrent and varied seizuresIn many patientsseizures are resistant to currently availabl ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. A Sensitive and Selective Microfluidic Nitrite Sensor

    SBC: CLINICAL SENSORS, INC.            Topic: 300

    PROJECT SUMMARYNitriteonce thought to simply be an intermediate of nitric oxideNOsynthesishas emerged as an important mediator of redox control and a major storage form of NO produced in the vasculatureIt has become clear that nitrite itself is involved in the regulation of vascular toneespecially in response to hypoxiaAssays to measure nitrite are employed across a broad range of clinical researc ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. 3D Holographic Guidance, Navigation, and Control (3D GN&C) for Endovascular Aortic Repair (EVAR)

    SBC: Centerline Biomedical, Inc.            Topic: NHLBI

    Project Summary This project will develop newD visualization to improve stent graft deployment during minimally invasive endovascular aortic repairEVARby overcoming limitations ofD x ray fluoroscopyfluoroD holographic guidancenavigation and controlD GNandamp Cwill be provided to decrease fluoro radiation dose burden to patients and OR staff during treatment of aortic aneurysmsparticularly when dep ...

    STTR Phase I 2018 Department of Health and Human Services

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