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SBC: SignalRx Pharmaceuticals Inc. Topic: 102
DESCRIPTION provided by applicant There is an unmet need to inhibit the key cancer promoting transcription factor MYC MYC both cMYC and MYCN acts downstream of many cell receptor complexes and signal transduction pathways to activate genes that drive cancer cell growth and proliferation To date small molecule inhibitors of MYC have been elusive An innovative approach would be to indirectl ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: NeoVative, Inc. Topic: NHLBI
DESCRIPTION provided by applicant Asthma is the most common chronic illness of childhood but many children have poorly controlled symptoms causing morbidities hospitalizations and costs The first step toward good asthma control is accurate assessment of symptoms Recall of the frequency and severity of symptoms is the cornerstone of asthma assessment Unfortunately recall by parents or ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: Vivoscript, Inc. Topic: 200
DESCRIPTION provided by applicant The groundbreaking discovery of induced pluripotent stem cells iPSCs has opened a new page for developing personalized cell based therapies against various devastating human diseases without ethical concerns of using human embryonic stem cells However the future clinical applications of iPSCs remain in doubt due to potential risks of undesired genomic alter ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: IMMUNOBLUE, LLC Topic: NCI
PROJECT SUMMARY Melanoma is one of the most prevalent cancers and is estimated to account for overdeaths inin the United States aloneAlthough highly curable when detected earlytheyear survival rates decline precipitously for patients with regionaland metastaticmelanoma indicating a lack of efficacy of conventional therapiesand a strong need for novel therapies for this patient populationIn respons ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: Novici Biotech LLC Topic: NHLBI
DESCRIPTION provided by applicant Fibroproliferative illnesses leading to organ fibrosis and failure are responsible for approximately of deaths in developed countries whether idiopathic triggered by environmental factors infections or genetics organ fibrosis results in significant morbidity and mortality Organ fibrosis is responsible for health care costs exceeding $ billion year ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: COG ANALYTICS, LLC Topic: 400
DESCRIPTION provided by applicant The early onset of alcohol misuse during adolescence is a widespread problem in the U S Studies have consistently documented both the short and long term adverse neurophysiological impacts and health risk behaviors associated with alcohol misuse during adolescence Given the magnitude of this problem and its myriad consequences preventing early initiation of ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: Fawkes Biotechnology, LLC Topic: 100
Traumatic brain injuryTBIis a substantial health care issue affecting both civilian and military populationsAlthough extremes of head injury are recognizablemild to moderate TBImmTBIis more difficult to diagnose leading to a need for the identification of circulating biomarkers of brain injury that may facilitate early identificationUsing a rat model of TBI we identified a novel marker of neuronal ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
Formation and Structural Property Relationships of a Tetracalcium Phosphate Bone Adhesive BiomaterialSBC: RevBio, Inc Topic: NIA
Project Abstract Approximatelyof all fractures occur in the small bones of the wristshands and feetamounting to more thanmillion annuallyConsidering functional losses associated with the locations of these injuriesproper reduction and fixation is critical to ensure optimal rehabilitation and recoveryComplex injuries that include irreducible fractures or segmental bone loss require operative fixati ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: COLORADO RESEARCH PARTNERS LLC Topic: NIDDK
DESCRIPTION provided by applicant Intake of added sweeteners high fructose corn syrup and sucrose independently predicts the development of obesity metabolic syndrome and diabetes Despite recommendations by WHO and the AHA to reduce sugar intake to to percent of total energy intake the mean intake of added sugars remains percent of the diet and percent of the population ingest ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: EyeMedix, Inc. Topic: N
DESCRIPTION provided by applicant Retinal diseases including age related macular degeneration AMD diabetic retinopathy DR diabetic macular edema DME and retina vein occlusion RVO are the leading causes of vision loss and blindness in people over years old According to the NEI in nearly million people in the U S suffered from some form of these diseases whose prevalen ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health