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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Development of a topical fixed-dose combination drug for peripheral neuropathic pain.

    SBC: WinSanTor, Inc.            Topic: NINDS

    PROJECT SUMMARY An estimated 30 million people in the United States suffer from some form of peripheral neuropathy, a condition that develops as a result of damage to the peripheral nervous system. The top two major causes of peripheral neuropathy in the US are diabetes mellitus (both T1DM and T2DM) and chemotherapeutic agents. Currently, there are no FDA-approved treatments to prevent or reverse ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  2. Image Analysis Tools for mpMRI Prostate Cancer Diagnosis Using PI-RADS

    SBC: Eigen Health Services LLC            Topic: 102

    Project Summary Prostate cancer is one of the most commonly occurring forms of cancer, accounting for 21% of all cancer in men. The Prostate Imaging Reporting and Data System (PI-RADS) aims to standardize reporting of prostate cancer using multi-parametric magnetic resonance imaging (mpMRI). However, the in-depth analysis, as demanded by PI-RADS, remains challenging due to the complexity and heter ...

    STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  3. Multi-Modality Image Data Fusion and Machine Learning Approaches for Personalized Diagnostics and Prognostics of MCI due to AD

    SBC: MS Technologies Corporation            Topic: R

    Alzheimer’s Disease (AD) is a devastating neurodegenerative disease. The greatest treatment potential lies in early stages before irreversible brain damage occurs. Early treatment requires early detection of the disease. Imaging holds great promise for capturing early signs of AD. This capability can be substantially strengthened by integrating neuroimages of different modalities that characteri ...

    STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  4. Development of perivascular space mapping toolset as a diagnostic aid for Alzheimer's disease

    SBC: NEUROSCOPE INC.            Topic: NIA

    Project Summary Alzheimer’s disease (AD) is a devastating disease that affects millions of Americans and imposes a huge socio- economic burden. AD-related cognitive decline is associated with the accumulation of Aβ (Amyloid beta) plaques and neurofibrillary tangles of hyperphosphorylated tau protein, which are insufficiently cleared and degraded by mechanisms such as the glia-lymphatic system o ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  5. Engineered Cyclodextrins to Address 7-ketocholesterol-Associated Diseases ofAging

    SBC: UNDERDOG PHARMACEUTICALS, INC.            Topic: NIA

    Project Summary/Abstract Underdog Pharmaceuticals, Inc. (UDP), in collaboration with the SENS Research Foundation (SRF), aims to demonstrate that 7-ketocholesterol (7KC) is elevated in red blood cells (RBCs) in Atherosclerosis and Alzheimer’s disease. 7KC is primarily created by non-enzymatic oxidation of cholesterol. With only a few exceptions, human tissues lack the ability to metabolize or ex ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  6. Eliminating Acne Through Photo-Inactivation Catalase

    SBC: PULSETHERA CORP            Topic: NIAMS

    PROJECT SUMMARYAcne vulgaris is a skin inflammatory condition affecting 80% of young adults and can frequently induce permanent disfigurement even with appropriate treatment. Acne is caused by C. acnes in the setting of hormonal changes and sebum induction that accompany adolescence. The mainstay of therapeutics consist of eradicating C. acnes and reducing inflammation. However, treatment is prolo ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  7. Development of a protein palmitoylation assay to monitor treatment of CLN1 Batten Disease

    SBC: Circumvent Pharmaceuticals            Topic: NICHD

    SummaryIn the Specific Aims outlined by the following proposal for an NIH SBIR Phase 1 project, we will use a multi-faceted approach to identify key substrates for targeted assay development to monitor therapy in for CLN1 Batten Disease (CLN1). CLN1 is an ultra-rare neurodegenerative disease that affects children with autosomal recessive mutations in the gene for palmitoyl-protein thioesterase 1 ( ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  8. Development of a commercially viable machine learning product to automatically detect rotator cuff muscle pathology

    SBC: SPRINGBOK INC            Topic: NIAMS

    PROJECT SUMMARY Rotator cuff tears are highly problematic for large patient populations, and therefore remain a very challenging clinical problem. Roughly 20% to 50% of those 60 years of age have a known rotator cuff tear and the prevalence only increases with age. While surgical reconstruction of the rotator cuff seeks to improve shoulder function and stability, the degrees of successful surgical ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  9. Smart, integrated well-plates for ultra-high-throughput screening of excitation-contraction coupling in tissues

    SBC: FORCYTE BIOTECHNOLOGIES, INC.            Topic: NIGMS

    Project Summary Heart disease remains the leading cause of mortality in the world and, drug-induced cardiotoxicity is a major cause of drug failure and withdrawal from the clinic or the market, contributing to the poor overall success rate of drug development programs. In vitro models of cardiac contractility have the potential to generate predictive data earlier in the pipeline to reduce later-st ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  10. Long-lived Platform Development for Exonuclease-Based Sequencing

    SBC: ELECTRONIC BIOSCIENCES, INC.            Topic: 172

    Project Summary During this project, Electronic BioSicences (EBS) and Professor Meni Wanunu (at Northeastern University) will develop a true single-molecule, direct, long-lived, RNA sequencer. The developed RNA sequencer will be capable of sequencing RNA with high-accuracy (andgt;99%), as well as iteratively sequencing various samples and quantitatively profiling the RNA content of a given sample, ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
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