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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. An unique patient population for clinical trials against noise-induced hearing loss

    SBC: GATEWAY BIOTECHNOLOGY, INC.            Topic: NIDCD

    AbstractNoise is the number one occupational and environmental hazardand noiseinduced hearing lossNIHLis one common form of sensorineural hearing deficitonly second to age related hearing lossCurrently no drug preventing NIHL is approved by the United States Food and Drug AdministrationFDAOne major challenge for the introduction of such interventions is the need to identify appropriate human popul ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Magnetically Enhanced Diffusion for Intra-Arterial Treatment of Acute Ischemic Stroke

    SBC: Pulse Therapeutics, Inc.            Topic: 101

    Acute ischemic strokeAISis the result of a blood clot in a cerebral arteryCurrentlyAIS remains a leading killer and the leading cause of long term disabilitywhich annually impacts nearlyAmericansBecause brain tissue rapidly diestime to reperfusion is critical in both preventing death and improving neurological outcomesWhile economic burden associated with ischemic stroke are high in the United Sta ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Rapid Test to Assist Therapy in Neonatal Sepsis and Necrotizing Enterocolitis

    SBC: PROTHERA BIOLOGICS, INC.            Topic: R

    The primary goal of this proposed research is to develop a rapid point of care test that assesses the risk of neonatal sepsisNSand or necrotizing enterocolitisNECin infants based on Inter alpha inhibitor proteinsIAIPlevels in bloodThe test is expected to be simpleuser friendlyportable and suitable for use in the NICUNS and NEC are associated with high mortality and morbidityincluding adverse neuro ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Multi-release drug-coated balloons for the treatment of peripheral artery disease with long, diffuse, and multiple lesions

    SBC: Tailored Medical Devices Inc.            Topic: NHLBI

    Project Summary Abstract Peripheral artery diseasePADaffects overmillion people worldwide and can result in life threating complicationsCurrentlydrug coated balloonsDCBsare used to treat lesions in the peripheral arteriesHowevercommercially available DCBs are designed to treat only a single blockage siteIn PAD patientscomplex lesions involving longdiffuseand or multiple blockages are often found r ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Smart Sensor Bandage for Ulcer Monitoring

    SBC: STOECKER MD, WILLIAM V            Topic: 600

    AbstractSmart Sensor Bandage for Ulcer Monitoring Non healing pressure ulcers result in approximately $billion in additional treatments each year in the United Statesraising in hospital mortality by nearly threefold and lengthening hospital stay by more than double when ulcers are presentThis burden is particularly pronounced in assisted living facilities where occurrence is high and skilled nursi ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Developing a new AAV-based tool for targeted gene therapy against hearing loss

    SBC: GATEWAY BIOTECHNOLOGY, INC.            Topic: NIDCD

    Project Summary Gene therapy mediated by recombinant adeno associated virusrAAVvectors has been clinically successful for the treatment of certain eye diseasesHoweverno successful clinical outcomes exist to treat hearing lossSince the cochlea is enclosed mostly within the temporal bonelocal viral gene delivery can itself cause hearing lossIn additionthe elaborate structure and exquisite function o ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Establishing the POROS Intracellular Delivery System as a Platform for Cellular Therapeutics

    SBC: OPENCELL TECHNOLOGIES, INC.            Topic: 100

    Abstract SignificanceIntracellular delivery of nucleic acids to immune cells is an important component of many current and anticipated cellular therapiesincluding chimeric antigen receptor T CellCAR Ttherapies for the treatment of cancerThese therapies use immune cells called T cellseither from the patient themselvesor a healthy donorand genetically engineer them to kill the tumor cellsThe genetic ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. In-Situ Cryopreservation Without Cryoprotectants

    SBC: CRYOCRATE LLC            Topic: 100

    SUMMARY With recent rapid advances in biomedical technologiesastronomical numbers of cell lines are emerging as highly valuable and promising products for therapies or critical research toolsThe ability to preserve stocks of quality controlled cells on both industrial and laboratory scales is an important challengedue to numerous technical and practical issues and regulatory concerns associated wi ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Develop novel lutein biomanufacturing in a nonmodel yeast via engineered metabolons and metabolic analyses

    SBC: Arch Innotek, LLC            Topic: 300

    Project Summary Arch Innotek proposes to develop a sustainablecost effective fermentation process to produce lutein using engineered yeastLutein is an important antioxidant compound that can slow the progression of vision loss caused by age related macular degenerationAMDcataractsand retinitis pigmentosaAside from protecting eyesdietary intake of lutein can reduce risk of skin disordersseveral typ ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. A Deep Learning Model to Improve Pathologist Interpretation of Donor Kidney Biopsies

    SBC: NEWVENTUREIQ LLC            Topic: 300

    PROJECT SUMMARY ABSTRACT More people die every year from kidney disease than breast or prostate cancerKidney transplantation is life saving but is limited by a shortage of organ donors and an unacceptably high donor organ discard rateThe decision to use or discard a donor kidney relies heavily on manual quantitation of key microscopic findings by pathologistsA major limitation of this microscopic ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
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