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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 19521 - 19530 of 23610 results
  1. High-throughput profiling of compound abuse liabilities and identification of addiction-related drug targets using an iPSC-enabled platform

    SBC: CAIRN BIOSCIENCES INC            Topic: NIDA

    Project Summary Abstract The scale of the US opioid addiction crisis clearly evidences the critical need for breakthroughs to assess compound abuse liabilities and to enable discovery of new analgesics with minimal abuse potentialWe hypothesize that altered addiction associated physiology can be modeled in co cultured hiPSC derived neuronal and astrocyte cells and detected by profiling gene expres ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. NarcoBond: Opioid Targeted Biomimetic Nanosponges for Treatment of Opioid Overdose

    SBC: CiBots            Topic: NIDA

    Abstract We propose to develop a broad acute/sub-acute opioid drug detoxifying treatment for opioid overdose that can complement andamp; compensate for the deficiencies in nalaxone, using opioid-targeted biomimetic “nanosponges” that absorb overdosed opioids in the body. (Note: if this proof-of-concept is successful here, the approach may be tailored to other drugs-of-abuse.) Called “NarcoBo ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Combined In-Situ / Ex-Situ Remediation of PFAS at Hazardous Waste Sites

    SBC: ENCHEM ENGINEERING, INC.            Topic: NIEHS

    Poly- and perfluoroalkyl substances (PFAS) in soil and groundwater are currently remediated by extracting the contaminated groundwater for ex-situ treatment via adsorption onto granular activated carbon (GAC) or other sorbents which only transfers contaminants to another media that still needs to be treated. This is a very long- term and expensive process because 1) it takes decades for the sorbed ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Development and Validation of a Collaborative Web/Cloud-Based Dosimetry System for Radiopharmaceutical Therapy.

    SBC: RADIOPHARMACEUTICAL IMAGING AND DOSIMETRY, LLC            Topic: 101

    Project SummaryRadiopharmaceutical therapy (RPT) – the use of targeted radionuclides to deliver radiation specifically to cancer cells and their microenvironment – is a fundamentally different approach to cancer therapy that is growing, with a substantial number of large and small pharmaceuticals companies developing products in this area and radionuclide producers making substantial investmen ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Development and Validation of Liquid Biopsy ddPCR and Next Generation Sequencing Assays for Diffuse Midline Glioma, K27M Variant

    SBC: RESOURCEPATH LLC            Topic: 102

    PROJECT SUMMARY ABSTRACT Diffuse intrinsic pontine gliomaDIPGaffecting an estimatedchildren in the United States per yearis one of the deadliest cancers of any typeThe median survival for children with DIPG is less than one year from diagnosiswhich has not changed in three decadesThe diagnosis of DIPG is typically made using clinical symptoms and magnetic resonanceMRscansBecause of the location of ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Development of the GlycoFibrotyper for detection of liver fibrosis

    SBC: GLYCOPATH INC            Topic: 300

    Increasinglyalterations in N linked glycans have been reported for serum or plasmaor for the most abundant serum glycoproteinimmunoglobulin Gfrom large cohorts of samples representing rheumatoid arthritisdigestive diseasescancer and liver fibrosisIn the case of fibrosistwo tests have identified alterations in Nlinked glycosylation on both total IgG populations and on specific IgG moleculesBoth of ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Head-mounted miniature microscopes for combined calcium imaging and electrophysiological measurement of neural circuit function in deep brain regions of behaving macaques

    SBC: Inscopix, Inc.            Topic: 101

    PROJECT SUMMARY A consensus has emerged in the Neurosciences over the last decade regarding the critical importance of understanding brain function at the level of neural circuits. Such an understanding can help us bridge across scales of investigation to provide a more comprehensive model of brain function, while also providing a more direct link to the dysfunctions associated with neurological d ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Developing EXP-1801 as an imaging agent to quantify pain and analgesia

    SBC: Expesicor Inc            Topic: NINDS

    Summary Abstract There are currently no tools available that can objectively measure painHistoricallypain in humans has been measured using subjective ratings to determine presence and severityIn animal modelspain is measured by semi quantitative assays that rely on the observation of pain behaviorsThough usefulthe inherently subjective nature of these measures has hampered both research and treat ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. STTR Phase I Development of Novel Antibacterial and Antifungal Bioadhesive Biomaterials for Diabetic Skin Wound Healing

    SBC: DYNAMIC ENTROPY TECHNOLOGY, LLC            Topic: NIDDK

    Abstract Diabetic ulcers or pressure ulcers are common for patients with diabetesspinal cord injuriesetcWithout proper managementsuch wounds often lead to infections such as osteomyelitis or sepsisresulting in high mortality and morbidityIn addition to bacterial infectiondiabetic patients are also more susceptible to cutaneous fungal infectionsAdvanced wound dressings and advanced wound therapies ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Stream Dx: Point of Care Cellular Enabled IoT Communication Hub for Improved Diagnosis, Monitoring, and Post-Treatment Evaluation of LUTS

    SBC: STREAM DX, INC            Topic: 400

    PROJECT SUMMARY / ABSTRACT - STREAM DX Lower urinary tract symptoms (LUTS) is one of the most common medical problems among older men – affecting 33% of men by the time they reach 50 years of age and 75% by the time they reach the age of 80. LUTS is a progressive disease that has been shown to significantly increase the risk of depression and reduce quality of life. Early detection, intervention ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
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