Award Data

PSORIASIS IS A DISEASE THAT AFFECTS MILLIONS OF AMERICANS WITH CHRONIC RECURRENT EXACERBATIONS AND REMISSIONS THAT AREEMOTIONALLY AND PHYSICALLY DEBILITATING. SEVERAL TREATMENTSARE AVAILABLE, BUT IN MANY CASES THESE ARE INADEQUATE. THIS APPLICATION IS BASED ON THE PREMISE THAT TOPICAL ADMINISTRATION OF PRODRUGS SHOULD RESULT IN HIGH CONCENTRATIONS OF THE ACTIVE DRUG AT THE LESION SITE WITH LOWER C ...

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THE LONG-TERM OBJECTIVE OF THIS PROJECT IS TO DEVELOP A COMMERCIAL PRODUCT FOR THE TOPICAL TREATMENT OF ACNE AND SKIN DISEASES. THE SPECIFIC AIM OF THE PROPOSAL IS TO INVENT A PRODRUG THAT CAN BE USED EFFECTIVELY AND SAFELY FOR THE TOPICAL TREATMENT OF ACNE. SINCE ISOTRETINOIN (13-CIS-RETINOIC ACID, ACCUTANE-ROCHE) ADMINISTERED ORALLY CAUSES BIRTH DEFECTS AND APPLIED TOPICALLY IS IRRITATING, WE HA ...

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Summary Oral mucositisa severe oral ulcerationis a common toxic effect of radioor chemoradio therapy and a limiting factor to using the maximum dose of radiation for effective cancer treatmentAt leastand up toof cancer patients treated with standard chemotherapy regimens or upper body radiation develop oral mucositisIntensity modulated RTIMRTlessens chronic side effectsbut not the acute toxicity s ...

DESCRIPTION: (Verbatim) A National Institutes of Health study has indicated that "hair loss during cancer chemotherapy is probably the most troubling aspect of cancer treatment, it is psychologically debilitating and adds to the overall trauma of the cancer diagnosis and . treatment." We have developed a topically applied pharmaceutical, called ProDermaCel, that h ...

DESCRIPTION (provided by applicant): Malignant melanoma's incidence is increasing by 2.7% annually even as most other cancers are experiencing a decline in incidence. The long-term objective of this project is to commercialize a topical formulation containing retinoic acid (ATRA) for subjects with dysplastic nevi at a higher risk of developing malignant melanoma. However, ATRA is highly irritating ...

DESCRIPTION (provided by applicant): Malignant melanoma's incidence is increasing by 2.7% annually even as most other cancers are experiencing a decline in incidence. The long-term objective of this project is to commercialize a topical formulation containing retinoic acid (ATRA) for subjects with dysplastic nevi at a higher risk of developing malignant melanoma. However, ATRA is highly irritating ...

The goal of this program is to develop a topical pharmaceutical formulation containing an optimized drug candidate from the 5-(n-substituted)salicylanilide class of patented, Lipophilic, Antimicrobial, Anti-inflammatory Drugs (LAADs) for the treatment of Diabetic Foot Ulcer (DFU). The 5-(n-substituted)salicylanilides are unique in that they potently inhibit the growth of several Gram-positive and ...

Project SummaryAbstract Paclitaxel is widely used throughout the field of oncology with indications for the treatment of a number of solid tumorsThe most commonly reported neurotoxic effect of paclitaxel is peripheral sensory neuropathy which often limits the dose and frequency of paclitaxel treatmentNeuropathic pain management is currently aimed only at reducing symptoms and treatment of chronic ...