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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 195981 - 195990 of 207725 results
  1. TOPIC 447: DEVELOPMENT AND TESTING OF A NON-INVASIVE CRYO-DEVICE TO PREVENT CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY IN HANDS AND FEET OF CANCER PATIENTS RECEIVING TAXOL FOR BREAST CANCER.

    SBC: EISANA CORP            Topic: 447

    The objective of this proposal is to develop a prototype device capable of cooling extremities to a level sufficient for prevention of chemotherapy-induced peripheral neuropathy (CIPN). Such a product will enable healthcare providers to make available a solution to prevent the physical pain and reduction in quality of life resulting from CIPN. The following Aims will be completed: (1) design, buil ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  2. TOPIC 372: DEVELOPMENT AND VALIDATION OF CANINE SCFVS FOR PRE-CLINICAL DEVELOPMENT OF TARGETED THERAPEUTICS

    SBC: Vetigenics LLC            Topic: NCI

    The goal of this SBIR is to provide proof of concept of Vetigenicscanine derived scFv phage display platform for rapidcost effective production of highly versatilecanine derived scFvsscFvs against CDCDand CTLAthree high valueimmunological molecules being targeted by antibody based strategies in human cancer immunotherapywill be isolatedSelected scFvs will be sequenced and binding affinities determ ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Topic 372: Development and Validation of Non- Mouse Reagents to Enable Preclinical Development of Novel Therapeutics

    SBC: AVANTGEN INC            Topic: NCI

    There is an increasing appreciation that dogs with naturally occurring cancers may be a better model system for evaluating cancer therapeutics than the traditional mouse model systems. However, use of dogs for evaluating the emerging class of immunotherapeutics for oncology is limited by the availability of suitable reagents to mentor the response of the canine immune system. The majority of reage ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. TOPIC 372:DEVELOPMENT AND VALIDATION OF NON-MOUSE REAGENTS TO ENABLE PRECLINICAL DEVELOPMENT OF NOVEL THERAPEUTICS

    SBC: AVANTGEN INC            Topic: 372

    Dogs with naturally occurring cancers can serve as a better model system for evaluating novel cancer immuno-therapeutics than the traditional mouse model systems, and also provide a target patient group. However, use of canine cancer patients is currently limited by the availability of suitable reagents to monitor canine immune responses. The majority of commercially-available reagents for canine ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  5. TOPIC 389- DEVELOPMENT OF A MACHINE LEARNING MODEL FOR PROSTATE CANCER TREATMENT PLANNING

    SBC: Nicolalde R&D LLC            Topic: NCI

    This project s goal is to develop and test an application that uses Artificial IntelligenceAIto improve consistency and quality of RT treatment plans for prostate cancerBy understanding expert planner preferences in structure contouring and treatment planningand combining this rationale with data amassed in NRG clinical trialsAI models will be trained to produce contours and treatment plans achiev ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. TOPIC 45: DEVELOPMENT OF A SUICIDE PREVENTION TRAINING CURRICULUM FOR JUSTICE SYS

    SBC: POLICY RESEARCH ASSOCIATES INC            Topic: N/A

    N/A

    SBIR Phase I 2007 Department of Health and Human ServicesNational Institutes of Health
  7. TOPIC 45: DEVELOPMENT OF A SUICIDE PREVENTION TRAINING CURRICULUM FOR JUSTICE SYS

    SBC: POLICY RESEARCH ASSOCIATES INC            Topic: N/A

    This proposal provides for an enhancement of the Phase I core curriculum to include information on specific sociodemographic groups (women, minorities, elders, juveniles), issues relevant to myriad legal practice settings (domestic violence), and those suicides which leave a wake of pain and suffering for communities and families, murder-suicides. Furthermore, the curriculum will address the ethic ...

    SBIR Phase II 2008 Department of Health and Human ServicesNational Institutes of Health
  8. TOPIC 314: DEVELOPMENT OF HUMAN TISSUE CULTURE SYSTEM THAT MIMICS THE TUMOR MICRO

    SBC: HemoShear Therapeutics, LLC            Topic: NCI

    Not Available

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  9. TOPIC 403: DEVELOPMENT OF SPATIAL MICROPURIFICATION TECHNOLOGY

    SBC: AVONEAUX MEDICAL INSTITUTE, LLC            Topic: 403

    The tumor microenvironment (TME) comprises a mixture of cell types, including tumor cells, cancer sub-clones, metaplasia, dysplasia, desmoplasia, reactive fibroblasts, and a complex immune response. Measuring the molecular status of each cellular component within the TME is important to understanding tumor initiation and progression as well as in determining the interplay between cancer and normal ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  10. Topic 372: Development of the Fully Humanized 9-in-9-out Rat Drug Metabolism-CYP450 Model, Using the Active Genetic: Gene Drive Technology

    SBC: SYNBAL INC            Topic: NCI

    In this Fast track SBIR grant we aim, by the end of Phase II, to prepare and commercialize a fully humanized rat with Knock-out of many rat drug metabolism related CYP450's (9-in-9-out Rat Drug Metabolism-CYP450 Model) and Knock-in of the human counterpart. IN PHASE I we will develop an Active Genes: Gene Drive (AG:GD) rat - a rat with a properly configured Cas9 to power Active Genetics (AG); AND, ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
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