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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 195991 - 196000 of 207728 results
  1. TOPIC 314: DEVELOPMENT OF HUMAN TISSUE CULTURE SYSTEM THAT MIMICS THE TUMOR MICRO

    SBC: HemoShear Therapeutics, LLC            Topic: NCI

    Not Available

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  2. TOPIC 403: DEVELOPMENT OF SPATIAL MICROPURIFICATION TECHNOLOGY

    SBC: AVONEAUX MEDICAL INSTITUTE, LLC            Topic: 403

    The tumor microenvironment (TME) comprises a mixture of cell types, including tumor cells, cancer sub-clones, metaplasia, dysplasia, desmoplasia, reactive fibroblasts, and a complex immune response. Measuring the molecular status of each cellular component within the TME is important to understanding tumor initiation and progression as well as in determining the interplay between cancer and normal ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  3. Topic 372: Development of the Fully Humanized 9-in-9-out Rat Drug Metabolism-CYP450 Model, Using the Active Genetic: Gene Drive Technology

    SBC: SYNBAL INC            Topic: NCI

    In this Fast track SBIR grant we aim, by the end of Phase II, to prepare and commercialize a fully humanized rat with Knock-out of many rat drug metabolism related CYP450's (9-in-9-out Rat Drug Metabolism-CYP450 Model) and Knock-in of the human counterpart. IN PHASE I we will develop an Active Genes: Gene Drive (AG:GD) rat - a rat with a properly configured Cas9 to power Active Genetics (AG); AND, ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. TOPIC 229: DEV. OF MOLECULAR PHARMACODYNAMIC ASSAYS FOR TARGET

    SBC: BIOO SCIENTIFIC CORPORATION            Topic: N/A

    The research will result in new kits for quantitative detection and monitoring of hypoxia inducible factor-1 alpha (Hif-1a), a promising cellular target protein for pharmacological intervention. During the Phase 1 project, monoclonal antibodies will be developed and used to create highly sensitive ELISA assays for Hif-1a. Mice immunized with peptides derived from Hif-1a will be used to produce hyb ...

    SBIR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  5. Topic 369: DRUG DELIVERY SYSTEM TO SAVE HEARING DURING PEDIATRIC CHEMOTHERAPY REGIMENS

    SBC: Otomagnetics, Inc.            Topic: NCI

    Our company has invented a magnetic drug delivery device that we intend to develop to enable prevention of a major side effect of chemotherapy in children. Cisplatin and carboplatin chemotherapy regimens can lead to severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss is FDA listed on-label as a dose limiting toxicity. Hearing loss in kids has a dramatic impact on the ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Topic: 31d Title: 3D Diamond Detector for High-Rate Charged Particle Tracking

    SBC: EUCLID BEAMLABS LLC            Topic: 31d

    Detectors for very rare phenomena in high-intensity experiments require extreme precision of charged particle tracking at low momenta in sub-100 MeV/c range. This necessitates ultra-low mass design that corresponds to very thin detector thickness. In addition, the particle collision rates in future high-intensity experiments will increase by approximately one order of magnitude, imposing severe ra ...

    SBIR Phase I 2019 Department of Energy
  7. TOPIC 240 EARLY DIAGNOSTICS USING NANOTECHNOLOGIES-BASED IMAGING AND SENSING

    SBC: Magarray, Inc.            Topic: N/A

    N/A

    SBIR Phase I 2007 Department of Health and Human ServicesNational Institutes of Health
  8. Topic 12e: Modular intelligent ventilator platform for new and existing residential building ventilation

    SBC: PD3 TECHNOLOGIES, INC.            Topic: 12e

    The ideal state of any indoor lived-in environment is a balance of comfortable air temperature, air humidity and air quality, achieved with as little recurring energy as possible and irrespective of building design, age, geography, or ambient weather conditions. However, management of residential indoor air quality is typically left to a centralized HVAC system with a single thermostat feedback le ...

    SBIR Phase I 2021 Department of Energy
  9. Topic 377: Enabling Clinical Decision Support for Guideline Based Cancer Symptom Management

    SBC: KLESIS, LLC            Topic: NCI

    The objective of this proposal is to develop an electronic, rule-based clinical decision support system (CDS-Sx) that leverages national clinical practice guidelines (CPGs) to improve cancer symptom management. Specific tasks that will be performed include: 1) create software-ready computable algorithms for managing cancer-related fatigue and constipation that have been vetted with diverse cancer ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. TOPIC 386: ENGINEERING PROBIOTICS TO DELIVER CHEMOPREVENTATIVE AGENTS TO THE HUMAN GUT

    SBC: GENCIRQ, INC.            Topic: NCI

    Colorectal cancerCRCis the second most common cause of cancer death in the USwith more thanAmericans dying every year from CRCHigh risk populations that have been targeted for preventionwhich include patients with inherited CRC syndromes such as familial adenomatous polyposisFAPand Lynch syndromeThe challenge for chemopreventionis how to provide precision delivery and thus avoid unacceptable toxic ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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