You are here

Award Data

For best search results, use the search terms first and then apply the filters
Reset

The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 196001 - 196010 of 207725 results
  1. TOPIC 356: FLOUROGENIC ASSAY PLATFORM FOR CIRCULAR RNA DETECTION

    SBC: LUCERNA INC            Topic: NCI

    Circular RNAs (circRNAs) are a novel class of non-coding RNAs that are an abundant component of the epitranscriptome. Putative functions of circRNAs, include miRNA sequestration, RNA-binding protein scaffolding, mRNA trapping, and protein translation regulation. Deregulation in one or more of these roles has been linked to several types of cancer, including pancreatic cancer, basal cell carcinoma, ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. TOPIC 356: FLUOROGENIC ASSAY PLATFORM FOR CIRCULAR RNA DETECTION

    SBC: LUCERNA INC            Topic: NCI

    Circular RNAscircRNAsare a novel class of modified RNAs that are an abundant component of the epitranscriptomePutative functions of circRNAsinclude miRNA sequestrationRNA binding protein scaffoldingmRNA trappingand protein translation regulationDeregulation in one or more of these roles has been linked to several types of cancerOne well studied circRNAciRSis believed to act as a miRNAsponge and in ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Topic 375: 18F PET Tracer For Imaging PD-L1 (Moonshot)

    SBC: SIBTECH, INC.            Topic: NCI

    New therapies, designed to enhance anti-tumor immunity are based on the blockade of the checkpoint components, either PD-1 on immune cells or PD-L1 on tumor cells. This strategy, while being spectacularly successful in some patients for some cancers, fails for many other patients. The expression of PD-L1 is highly dynamic and its prevalence within tumors can vary significantly over time. The curre ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. TOPIC 397- FUNCTIONALLY CLOSED PURIFICATION AND ELUTION OF UNTOUCHED T CELLS USING CLEAVABLE MAGNETIC BEADS WITH RATCHETING CYTOMETRY

    SBC: FERROLOGIX INC            Topic: 397

    The goal of this effort is to develop a functionally closed, high throughput magnetic cell purification system which can achieve 1) purification of T cell populations directly from a leukopak biomatrix via positive selection and 2) cleavage of bead-cell bonds resulting in untouched T cells for cell therapy production. We believe that a functionally closed system that can achieve high purity positi ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  5. TOPIC 417: GPU-ACCELERATED 3D MONTE CARLO SPECT RECONSTRUCTION ALGORITHM FOR PERSONALIZED RADIOPHARMACEUTICAL THERAPY

    SBC: VOXIMETRY INC            Topic: 417

    Although radiopharmaceutical therapy (RPT) has worked well in patients with lymphoma, late-stage, metastatic prostate cancer, and neuroendocrine tumors, it is well known that because of variability in patient pharmacokinetics, standard dosing leads to clinical outcomes that are difficult to predict and drastically vary. However, it is possible to make RPT safer and more effective by first measurin ...

    SBIR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  6. TOPIC 353: HIGHLY ACCURATE LOW COST CTDNA DIAGNOSTICS WITH MAGNETIC NANOPARTICLE ENABLED AUTOMATED SAMPLE PREP- MOONSHOT

    SBC: NVIGEN            Topic: NCI

    The goal of the research is to develop a highly accurateautomatedand low cost ctDNA test to monitor efficacy of treatment of metastatic breast cancer patients by identifying the emergence of certain DNA mutations in plasma samplesThere is growing evidence that the presence of certain DNA mutations in the blood stream correlates with breast cancer becoming resistance to hormone treatmentNVIGEN will ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Topic 372: Highly multiplexed selection of aptamers to hundreds of canine immunotherapy targets

    SBC: BASE PAIR BIOTECHNOLOGIES INC            Topic: NCI

    The preclinical development of cancer therapeutics, including the recent trend and focus on cancer immunotherapies, is evolving from the traditional use of mouse models to the use of other animal models including canine, rat, and minipig. Each of these non-mouse models carries its own advantages and abilities to increase the clinical relevance of the model as compared to mouse models. Yet, the wid ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. TOPIC 396- IMAGING FOR CANCER IMMUNOTHERAPIES-MOONSHOT

    SBC: COLUMBUS NANOWORKS, INC.            Topic: NCI

    In vivo imaging of cells labeled with fluorescent nanodiamondsFNDsis a new way of monitoring immune cells during cancer immunotherapyFNDs are non toxicinfinitely photostable nanomaterials that are easily conjugated with antibodiesand emit fluorescence in the near infrared spectral regionIn this Phase I SBIRwe will use a murine melanoma model and outline a plan to use FNDs for imaging immunosupress ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. TOPIC 382- INTEGRATED IMAGING AND MOLECULAR ANALYSIS OF GLIOBLASTOMA USING SCOPE SEQ ON THE AIR FLOW

    SBC: CELL MICROSYSTEMS INC            Topic: NCI

    Combining both genomic analysis and highEresolution imaging on a cellEbyEcell basis typically relies on customized technology which often requires significant expertise and capital costCell MicrosystemsInchas partnered with Peter SimsPhD of Columbia University to commercialize a novel workflow for integrated imaging and sample preparation for single cell transcriptomic analysisDrSims workflowSingl ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. TOPIC 393: INTEGRATED PHOTONIC BIOSENSOR FOR PRECISION ONCOLOGY DOSE MEASUREMENTS

    SBC: INTELLIGENT FIBER OPTIC SYSTEMS CORP            Topic: NCI

    Radiation therapy is a widely used primary treatment for multiple malignanciesHoweverphysical dose measurement is not an effective approach as the biological response of different patients or even different types of cancers are very different for the same physical doseMoreoverdiseased tissue and normal organ radiation sensitivities also varyExisting medical devicesphysical dosimetersdo not satisfy ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
US Flag An Official Website of the United States Government