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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 196021 - 196030 of 207714 results
  1. TOPIC 428- NCI SBIR TRANSITION TO PHASE II SOLICITATION FY 2023

    SBC: EARLYDIAGNOSTICS INC            Topic: 428

    Integrative analysis of multi-omics datasets is revolutionizing cancer research and patient care. To take advantage of the full breadth of CRDC’s petabyte-scale data, EarlyDx will seamlessly integrate its liquid biopsy cloud-computing platform with CRDC data repositories. Liquid biopsies provide a non-invasive approach for interrogating the genomic and epigenomic profiles of tumors. Co-analysis ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  2. TOPIC 343: NEUROPSYCHOLOGICAL ASSESSMENT SYSTEM FOR CANCER PATIENTS

    SBC: CREARE LLC            Topic: NCI

    Cognitive decline is a major quality of life concern for many cancer survivorsThevarious available treatments affect individuals differentlyand research has unfortunately provided little guidance on how specific treatments impact neurocognitive functionTo help researchers fill this information gap and ultimately provide guidance to doctors and patientsa neuropsychological assessment system that is ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. TOPIC 396: NON-INVASIVE DETECTION OF HUMAN CD8+ T CELLS: A PET-BASED APPROACH TO ASSESS THE HUMAN IMMUNESYSTEM- MOONSHOT

    SBC: Revela Biotech LLC            Topic: NCI

    Immunotherapy has shown impressive success in treating several cancershoweverresponses to treatment are variableand predicting the response to therapy remains a major obstacleBiopsy analyses has correlated good prognosis with infiltration of CDT cells into the tumor and recent preclinical work suggests that tracking of CDT cells in tumors using single domain antibodyVHHbased PET imaging can accura ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Topic 376: Non-Invasive Subtyping of Aggressive Tumor and Its Environment- Moonshot

    SBC: INLIGHTA BIOSCIENCES L.L.C.            Topic: NCI

    Generation of high-resolution 3D anatomic and dynamic images without exposing patients to ionizing radiation renders MRI the preferred imaging modality for the detection of tumor extent and treatment response to neo-adjuvant and adjuvant medical therapies. The goal of this proposal is to develop a non-invasive, in vivo imaging-based platform that can repeatedly generate three-dimensional molecular ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Topic 375: Novel Diagnostic Imaging Modality for Monitoring Tumor Responses to a Hyperthermia Immunotherapy (Moonshot)

    SBC: Imago Systems, Inc.            Topic: NCI

    Immunotherapies have been emerging in the past decades as powerful approaches for cancer treatment. However, the immune system is complex, and therapy efficacy is substantially affected by the tumor microenvironment. For this reason, it is currently difficult to visualize tumor response and predict therapeutic efficacy. In this Contract, Imago Systems, Inc., a company with substantial experience i ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. TOPIC 369: NOVEL DOSING AND DISPENSING SYSTEM FOR MULTIPARTICULATE CANCER DRUGS

    SBC: HS-DESIGN, INC            Topic: NCI

    Oncology drugs continue to advance at a rapid pace with many therapies delivered orally as tablets or capsulesSmaller childrenhowevercannot swallow tablets or capsulesFor these drugs to be used in the pediatric population they need to be reformulatedTraditionally this has meant creating a liquid suspensionchewableor rapid dissolve tabletCancer medicationshoweveroften have terrible taste profiles t ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Topic 373: Novel Mass Spectrometry Methods and Research Tools to Map Nucleotide Modifications in Cytosolic Transfer RNAs from Cancer Cells

    SBC: Ribonova Inc.            Topic: NCI

    Chemical modifications play a crucial role in the regulation of biological processes. Protein function is often modulated by tagging with phosphates, sugars, or lipids, while epigenomic marks on DNA or histones can regulate gene expression up or down. One area that lags behind is the mechanistic understanding of the role of RNA chemical modifications, sometimes referred to as the 'epitranscriptome ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. TOPIC 386: NOVEL ORALLY BIOAVAILABLE PDE-CATENIN INHIBITOR CONCENTRATES IN LUNG FOR CANCER CHEMOPREVENTION

    SBC: ADT Pharmaceuticals, LLC            Topic: NCI

    This application is based on ADT Pharmaceuticalsdiscoveries thatthe cGMP degrading phosphodiesterase isozymephosphodiesteraseAPDEis overexpressed during early stages of tumorigenesisgenetic knockdown of PDEresults in selective apoptosis of tumor cells by activating cGMP PKG signalingandsmall molecule inhibitors of PDEinduce apoptosis by PKG phosphorylation of oncogeniccateninthereby suppressing Tc ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. TOPIC 269- NOVEL PROTEIN EXPRESSION TECHNOLOGIES FOR GLYCOPROTEINS

    SBC: LIFESENSORS, INC.            Topic: N/A

    Location 271 GREAT VALLEY PKY MALVERN, PA 19355 United States N43CO200900041 $149 550.00 2 009 TOPIC 269- NOVEL PROTEIN EXPRESSION TECHNOLOGIES FOR GLYCOPROTEINS Department of Health and Human Services National Institutes of Health SBIR PHS2009-1 LIFESENS ...

    SBIR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  10. TOPIC NUMBER: ARPA-H 05: SCALE-UP: TRANSITION DISRUPTIVE TECHNOLOGIES FROM PROOF-OF-CONCEPT PROTOTYPES TO COMMERCIALLY SCALABLE AND DEPLOYABLE TECHNOLOGIES

    SBC: BAYSPEC, INC.            Topic: AH05

    This project plans to design, optimize, test, and deliver two fully functional miniature, portable MALDI-2 imaging mass spectrometer (IMS) prototype systems capable of high-resolution imaging mass spectrometry. The miniaturized IMS will support a disruptive technology as a portable point-of-care clinical diagnostic. AX

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
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