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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 196041 - 196050 of 205043 results
  1. Microfluidic High-throughput Platform for Determining Kinetic Constants of Enzyme Variants

    SBC: CFD RESEARCH CORPORATION            Topic: CBD10107

    Current high-throughput platforms rely on labeled substrates that produce detectable spectroscopic signals upon reaction for monitoring enzyme catalytic activity. Add to that the high price tag for these instruments, ranging from several hundred thousand to millions of dollars, and there is a clear need for alternate solutions for a label-free, low-cost, high-throughput enzyme screening platform. ...

    SBIR Phase II 2011 Department of DefenseOffice for Chemical and Biological Defense
  2. A Novel Microfludic Device for Drug Toxicity Studies

    SBC: CFD RESEARCH CORPORATION            Topic: CBD10103

    Current drug discovery and development efforts are severely limited by expensive animal trials and oversimplified in vitro models. Results obtained from in vitro models are not predictive of in vivo toxicity owing to significant difference from the in vivo physiological conditions. In this context, we propose to develop and demonstrate a novel microfluidic device that reproduces the physiological ...

    SBIR Phase II 2011 Department of DefenseOffice for Chemical and Biological Defense
  3. Low noise longwave infrared (8-12µm) focal plane array with high sensitivity for passive hyperspectral standoff detection

    SBC: APPLIED NANOFEMTO TECHNOLOGIES LLC            Topic: CBD10105

    Longwave infrared (LWIR, 8-12µm) focal plane arrays (FPAs) play an important role in hyperspectral chemical and biological (CB) sensing and spectral imaging. Existing thermal detectors are unable to meet the high sensitivity and fast response requirements of many hyperspectral chemical and biological sensing applications. FPAs based on photon excited electron generation process can fulfill the sp ...

    SBIR Phase II 2011 Department of DefenseOffice for Chemical and Biological Defense
  4. Miniature Residual Life Indicator

    SBC: Physical Optics Corporation            Topic: CBD10106

    To address the Chemical and Biological Defense (CBD) need for a residual life indicator (RLI) capable of determining the degradation in physical adsorption and reactive capacity arising from battlefield contaminants and exposure to the elements, Physical Optics Corporation (POC) proposes to continue the development of a new Miniature Residual Life Indicator (MRLIN). MRLIN is based on impedance spe ...

    SBIR Phase II 2011 Department of DefenseOffice for Chemical and Biological Defense
  5. MEMS Lamellar Based Interferometer for the Detection of Toxic Chemicals

    SBC: AGILTRON, INC.            Topic: CBD10104

    Leveraging on Agiltron industry leading development of optical MEMS devices and the PI experience with FTIR spectrometer design, we propose to develop a new class of high performance compact and rugged FTIR spectrometers for the LWIR optical range. The design is based on the MEMS lamellar mirror technique. Although this approach is not new, it has not yet been efficiently applied to LWIR, and per ...

    SBIR Phase II 2011 Department of DefenseOffice for Chemical and Biological Defense
  6. A High-Throughput Blood Esterase Panel Assay

    SBC: AGAVE BIOSYSTEMS INC.            Topic: CBD10108

    Organophosphorus chemical warfare nerve agents (OP-CWA) are attractive to terrorist groups and rogue states as an inexpensive and accessible technology for chemical warfare. OP-CWA and organophosphate pesticides cause severe neurological symptoms and death by inhibiting the enzyme acetylcholinesterase (AChE); the resulting excess acetylcholine accumulates and overstimulates the human or animal bo ...

    SBIR Phase II 2011 Department of DefenseOffice for Chemical and Biological Defense
  7. Blood Brain Barrier Drug Delivery of Therapeutics for Chemical Warfare Agents

    SBC: IMPEL NEUROPHARMA, INC.            Topic: CBD10109

    Technical Abstract Impel NeuroPharma has developed a novel non-invasive delivery system, the POD device that targets drug to the upper third of the nasal cavity which results in direct and rapid transport of drug to the CNS via the olfactory perineural pathways, effectively bypassing the BBB. In Phase I of this research contract Impel successfully characterized and tested both an aqueous and a ...

    SBIR Phase II 2011 Department of DefenseOffice for Chemical and Biological Defense
  8. Characterization and Mitigation of Radiation Effects in Nonplanar Nano-technology Microelectronics

    SBC: CFD RESEARCH CORPORATION            Topic: DTRA092001

    Future high-performance integrated circuits in DoD satellite systems will require silicon-on-insulator (SOI) and non-planar nano-technology devices, such as MultiGate Field Effect Transistors (MuGFETs) or FinFETs, which can decrease pattern area of logic circuits below 50% of the conventional planar technologies. However, the single-event-effect (SEE) response of non-planar devices and circuits is ...

    SBIR Phase II 2011 Department of DefenseDefense Threat Reduction Agency
  9. Digital Data Recorder for Gauges in High Speed Weapons During Survivability Testing

    SBC: DYNAMIC SYSTEMS & RESEARCH CORP            Topic: DTRA092014

    The development of a high-shock data recorder for use in projectile penetration and pyrotechnic environments is critical to understanding the loads that warhead systems are exposed to in tactical applications. Data from recorders mounted inside warheads can be used by researchers to measure loads on the warhead, fuze, and explosive fill components as well as validate analytic and computational mo ...

    SBIR Phase II 2011 Department of DefenseDefense Threat Reduction Agency
  10. Weapon Payloads for Bulk Chemical and Biological Agent Neutralization

    SBC: Integrated Solutions for Systems, Inc.            Topic: DTRA092012

    Current offensive solutions to neutralize chem/bio agent facilities rely on blast and/or short-burst high-temperature neutralization but have the potential to produce severe collateral damage via agent release. Our team proposes the Dispersed Energetics Coupled for Optimized Neutralization (DECON) Concept, an alternative concept to perform bulk neutralization of agents. The DECON concept can be ...

    SBIR Phase II 2011 Department of DefenseDefense Threat Reduction Agency
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