Award Data

Oral mucositis (OM) is a common side effect in oncology patients receiving radiation treatment. Mucosal breakdown causes pain which leads to increased use of narcotic analgesics and restriction of food intake. OM often progresses to septicemia, increasinghospital stays and costs, and ultimately discontinuation of radiotherapy. This impacts overall effectiveness of cancer therapy so development of ...

Radiation insensitive tumors that become radiation resistant are often also invasive, metastatic, and responsible for most cancer deaths. Here, the long term objective is to complete clinical evaluation of an inhibitor of a new target (V-ATPase) that sensitizes tumors but not healthy tissues to radiation and inhibits multiple aspects of tumor metabolism and therapeutic resistance. Development o ...

The long-term goal of this proposal is to discover and develop small molecule drugs against Head and Neck Cancers (HNC). The focus is on drug candidates that target processes critical for repopulation after radiation treatment. The current proposal is to perform preliminary pharmacokinetics and toxicity studies and test the efficacy of a proprietary drug candidate on preclinical models of human HN ...

Extracellular-signal-regulated kinase (ERK) is a key protein kinase of the MAP kinase pathway and plays a key role in cell proliferation, differentiation and migration. The MAPK cascade presents many targets for the development of novel and safer cancer therapies. Despite a lot of progress in the discovery of therapeutic agents, a pharmacodynamic assay for ERK is missing. In this proposed research ...

This research project seeks to create innovative software that aids healthcare providers to calculate the out of pocket costs of patients receiving cancer treatmentThe goals of this SBIR project are to leverage the insights of stakeholderssubject matter experts and industry standards to create a software system that can be integrated into the workflow of providersIf we are successfulhealthcare pro ...

This research project seeks to create innovative software that aids healthcare providers to calculate the out-of-pocket costs of patients receiving cancer treatment. The goals of this SBIR project are to leverage the insights of stakeholders, subject matter experts and industry standards to create a software system that can be integrated into the workflow of providers. If we are successful, health ...

Cancer patients experience substantial functional impairments during and after treatments, often requiring rehabilitation and exercise interventions. However, a functional assessment of the specific deficits and impairments in the individual is needed to inform exercise therapy. The oncology workforce is challenged in its capacity to conduct such functional assessment, therefore limiting the abili ...

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A strong body of evidence suggests that addressing Social Determinants of Health (SDH) within healthcare systems advances cancer treatment adherence and reduces disparities in outcomes; however, few studies actually intervene and provide resources to meet cancer patients’ SDH. Integrating SDH with clinical information within operational Clinical Decision Support (CDS) systems built into Electron ...

SPADES: A system for Encouraging Adoption of New methods for Activity Monitoring PUBLIC HEALTH RELEVANCE