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Three-dimensional electron tomography can render images of the internal structure of solid-state and biological materials at the nanometer scale, and is finding increased application in nanotechnology, semiconductor industries, and the life sciences. However, current systems cannot acquire all the information necessary to construct an optimal tomogram. A major limitation is that these systems do ...

Electron microscopes are important tools for materials research. However, the current state of the art for the heating and cooling stages of these microscopes has five major limiting factors: (1) temperature limitation to 1600C, (2) substantial thermal drift, (3) vibration induced from cooling pumps, (4) inadequate temperature control, and (5) lack of reliability. This project will address thes ...

DESCRIPTION (provided by applicant): The long term objective of our application is to develop hardware and procedures that will allow researchers to better understand the function of the cell. Our specific aim is to provide a system that will allow researchers to better prepare frozen hydrated specimens for study via tomographic reconstruction in the transmission electron microscope(TEM) Current m ...

Project Summary The long term objective of our application is to develop hardware and procedures that will allow researchers to better understand the function of the cell. Our specific aim is to provide a system that will allow researches to better prepare frozen hydrated specimens for study via tomographic reconstruction in the transmission electron microscope(TEM) Current methods of preparing f ...

With the development of new nanostructured materials, there is an increasing need to quantify their basic properties. The small size scales of the materials complicate the adaptation of existing experimental approaches and require new instruments to perform basic measurements. This project will incorporate a fully-functional scanned-probe system into a sample holder for transmission electron micro ...

The addition of continuous fluid flow through a set of electron transparent windows in a transmission electron microscope (TEM) or scanning transmission electron microscope (STEM) will provide the ability to image reactions that occur at the nanoscale. In particular, liquid STEM presents a unique in situ electron microscopy tool to investigate energy conversion at the interface between solid and l ...

DESCRIPTION (provided by applicant): The objective of our application is to develop hardware and procedures that will allow researchers to practically utilize phase plates in the back focal plane of the objective lens in a Transmission Electron Microscope. Use of precisely positioned phase plates can increase resolution in electron tomography, and also increase throughput when using the single-par ...

DESCRIPTION (provided by applicant): Transmission electron microscope (TEM) tomography provides three-dimensional images at the nanometer scale. It is a mainstream technique in biological electron microscopy, and is rapidly finding applications in the semiconductor and nanotechnology industries. In biology, scientists are interested in producing faithful tomograms of frozen-hydrated samples, since ...

Researchers are currently hindered from observing dynamic liquid-liquid and liquid-solid interactions in transmission electron microscopes (TEMs) and scanning transmission electron microscopes (STEMs). Yet, solid-state materials and fluids interact in many important ways. For example, solid-state nanoparticles are formed via solution-based synthesis, and biological cells exist live only in a flu ...

The Department of Energy supports the microcharacterization of materials via Transmission Electron Microscopy (TEM) as a core research area. This project will expand the utility of TEM by developing an environmental holder for liquid and gaseous environments. While the proposed effort will focus on gas delivery, existing proven technology will be leveraged for liquid delivery. Thus, the result ...